Article
Orthopedics
Junya Itou, Umito Kuwashima, Masafumi Itoh, Ken Okazaki
Summary: The study found no differences in the incidence, location, or characteristics of DVT following TKA with or without pharmacological prophylaxis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Tao Jiang, Kai Song, Yao Yao, Zaikai Zhuang, Ying Shen, Xinhua Li, Zhihong Xu, Qing Jiang
Summary: This study aimed to observe the effects of graduated compression stockings on the vein deformation and hemodynamics of lower limbs in patients awaiting total hip arthroplasty. The results showed that thigh-length graduated compression stockings can compress the lower extremity veins when in a supine position, but do not significantly increase blood velocity in the common femoral vein or great saphenous vein.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Anne R. Bass, Yi Zhang, Bella Mehta, Huong T. Do, Linda A. Russell, Peter K. Sculco, Susan M. Goodman
Summary: This study found a strong association between periprosthetic joint infection and the risk of venous thromboembolism (VTE) following revision total knee replacement. The risk of VTE was higher after revision for infection or fracture compared to aseptic revision. The indication for revision total knee replacement should be considered when choosing postoperative VTE prophylaxis.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Health Care Sciences & Services
Jang-Hyuk Cho, Dong-Gyu Lee
Summary: Based on a retrospective analysis of patients with spinal cord injury from 2016 to 2020, Asian patients with spinal cord injury have a low incidence of below-knee deep vein thrombosis and a favorable natural history of the condition, recommending serial imaging over anticoagulant therapy for these patients.
Article
Gastroenterology & Hepatology
Adam S. Faye, Kate E. Lee, John Dodson, Joshua Chodosh, David Hudesman, Feza Remzi, Jason D. Wright, Alexander M. Friedman, Aasma Shaukat, Timothy Wen
Summary: VTE-associated hospitalisations are increasing among patients with inflammatory bowel disease (IBD), and are associated with factors such as age, sex, type of IBD, race, and chronic corticosteroid use. Continued efforts for education and risk reduction are crucial.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Surgery
Brianna Herring, Darren Lowen, Prahlad Ho, Russell Hodgson
Summary: This study compares the safety and efficacy of intermittent pneumatic compression (IPC) and graduated compression stockings (GCS) for venous thromboembolism (VTE) prevention. The results suggest that IPC may be superior to GCS as a single prophylactic device. Combination mechanical prophylaxis of IPC and GCS may be more effective than GCS alone for high-risk patients. However, more high-quality research is needed in this field.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Medicine, General & Internal
Elad Neeman, Vincent Liu, Pranita Mishra, Khanh K. Thai, James Xu, Heather A. Clancy, David Schlessinger, Raymond Liu
Summary: This study examines the incidence, risk factors, and outcomes of hospital-associated venous thromboembolism (HA-VTE) using a retrospective analysis of electronic health records. The results show that HA-VTE events occurred in 1.2% of medical admissions and increased over time, leading to adverse outcomes. These findings highlight the importance of implementing strategies to prevent and manage HA-VTE.
Article
Orthopedics
Nathanael D. Heckmann, Amit S. Piple, Jennifer C. Wang, Mary K. Richardson, Cory K. Mayfield, Daniel A. Oakes, Alexander B. Christ, Jay R. Lieberman
Summary: This study aimed to evaluate the risk of pulmonary embolism (PE) and deep vein thrombosis (DVT) in patients who received aspirin and warfarin while accounting for surgeon selection bias. The results showed that aspirin was as effective as warfarin at preventing PE and DVT, and aspirin was associated with a lower risk of transfusion compared to warfarin.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Hematology
Douglas Buckheit, Amanda Lefemine, Diana M. Sobieraj, Laura Hobbs
Summary: The study found that reducing anticoagulant doses for VTE prophylaxis in underweight medical patients is a common practice and is associated with less major bleeding. However, the incidence of clinically relevant non-major bleeding and VTE was similar between the two groups.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Article
Orthopedics
Raju Easwaran, Moin Khan, Parag Sancheti, Ashok Shyam, Mohit Bhandari, Anil S. Ranawat, Savyasachi Thakkar, Shital Parikh, Volker Musahl, Siddharth Joglekar, Ajit J. Deshmukh, Kevin Plancher, Nikhil Verma, David McAllister, Peter Verdonk, Sebastien Lustig, Amit Chandrateya, Robert Smigleiski, Gandhi Solayar, Bancha Chernchujit, Patrick Yung, Nicolaas Budhiparama, Yuichi Hoshino, Nathan White, David Parker, Mark Clatworthy, Charlie Brown, Mojieb Manzary, David Rajan, Abhay Narvekar, Sachin Tapasvi, Dinshaw Pardiwala, Ranjit Panigrahi, S. Arumugam, Vikash Kapoor, Bharat Mody, Jitender Maheshwari, Vivek Dahiya, Clement Joseph, Mukesh Laddha, Ashok Rajgopal
Summary: There is a lack of consensus on the need for Venous Thrombo Embolism (VTE) prophylaxis following arthroscopic knee surgery and open soft tissue knee reconstruction. This study conducted a modified Delphi questionnaire to gather opinions from international experts. The results showed that there are certain patient factors, prolonged surgery duration, and family history of thrombogenic events that should be taken into consideration for prophylaxis. The study concluded that there is a select group of patients undergoing arthroscopic surgery that justify the usage of VTE prophylaxis.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Multidisciplinary Sciences
Pengfei Wang, Xinan Yan, Chen Fei, Binfei Zhang, Jian Xing, Kun Zhang, Utku Kandemir
Summary: This study investigated the incidence and risk factors of clinically important venous thromboembolism (CIVTE) in patients with tibial plateau fractures. The study found that the incidence of CIVTE was relatively high (8.4%) and that male gender, spine injury, other extremity injury, and length of stay in ICU were independent risk factors.
SCIENTIFIC REPORTS
(2022)
Review
Obstetrics & Gynecology
Alexander M. Friedman, Mary E. D'Alton
Summary: Venous thromboembolism is a significant contributor to maternal mortality in the United States, with the overall maternal mortality rate increasing in recent years, likely leading to an increased risk of venous thromboembolism. Experts suggest that improving clinical care is necessary to reduce this risk, and enhancing prophylaxis and prevention may provide the greatest benefit. However, there is controversy on the best approach to improve prophylaxis, with concerns over safety, efficacy, and cost.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Instruments & Instrumentation
Shuyuan Hua, Yiwen Liu, Jinhua Jiang, Fei Xiao, Ruihang Hou, Aijia Li, Xiaorong Cai, Xiangjun Hu, Xifan Ding, Xuejun Jin
Summary: Deep venous thrombosis (DVT) is a severe venous disease with high incidence and mortality rate. Graduated compression stockings (GCSs) have been proven effective in reducing DVT incidence, but their prophylactic effect in daily life is limited due to low compliance and static pressure. To address this issue, a smart graduated compression stocking (SGCS) based on shape memory alloy (SMA) was designed, prototyped, and tested in this research. The SGCS was accompanied by a mobile App that modulated dynamic pressure and monitored health conditions such as temperature and pulse in real-time.
SMART MATERIALS AND STRUCTURES
(2023)
Article
Clinical Neurology
Liqi Shu, Adam de Havenon, Ava L. Liberman, Nils Henninger, Eric Goldstein, Michael E. Reznik, Ali Mahta, Fawaz Al-Mufti, Jennifer Frontera, Karen Furie, Shadi Yaghi
Summary: This study evaluated the rates and risk factors for hospital readmissions with venous thromboembolism (VTE) after an intracerebral hemorrhage (ICH) or acute ischemic stroke (AIS) hospitalization. The results showed that the rate of VTE readmission was nearly three times higher in ICH patients compared to AIS patients, and the highest risk period for VTE readmission was within the first 4-6 weeks post-discharge. Therefore, there is a need to test short-term VTE prophylaxis beyond hospitalization in high-risk patients.
Article
Medicine, General & Internal
Huijie Wang, Mary Cushman, Frits R. Rosendaal, Astrid van Hylckama Vlieg
Summary: This study found that a remote history of venous thrombosis (VT) is associated with an increased risk of VT in older individuals, providing valuable information for clinicians to advise patients on VT prevention.
Article
Clinical Neurology
Zien Zhou, Chao Xia, Grant Mair, Candice Delcourt, Sohei Yoshimura, Xiaosheng Liu, Zengai Chen, Alejandra Malavera, Cheryl Carcel, Xiaoying Chen, Xia Wang, Rustam Al-Shahi Salman, Thompson G. Robinson, Richard Lindley, John Chalmers, Joanna M. Wardlaw, Mark W. Parsons, Andrew M. Demchuk, Craig S. Anderson
Summary: According to the analysis from the ENCHANTED study, the influence of alteplase dose or intensity of blood pressure lowering on functional outcomes is not modified by the status/location of vascular obstruction. However, the results are limited by low statistical power.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Richard Lindley, Ingrid Kane, Geoff Cohen, Peter A. G. Sandercock
Summary: This study investigated the complex issue of obtaining informed consent in acute stroke patients and analyzed the clinical characteristics of patients recruited by different consent methods and their association with the time from stroke onset to randomization. Flexible consent methods were found to be essential in ensuring a broad range of patients are recruited, minimizing selection bias in acute stroke trials.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Craig S. Anderson, Anthony Rodgers, H. Asita de Silva, Sheila Ouriques Martins, Catharina J. M. Klijn, Bimsara Senanayake, Ruth Freed, Laurent Billot, Hisatomi Arima, Nguyen Huy Thang, Wan Asyraf Wan Zaidi, Tinatin Kherkheulidze, Kolawole Wahab, Urs Fisher, Tsong-Hai Lee, Christopher Chen, Octavio Pontes-Neto, Thompson Robinson, Jiguang Wang, Sharon Naismith, Lili Song, Floris H. Schreuder, Richard Lindley, Mark Woodward, Stephen MacMahon, Rustam Al-Shahi Salman, Clara K. Chow, John Chalmers
Summary: The study investigates the effects of a novel Triple Pill on the prevention of recurrent stroke, cardiovascular events, and cognitive impairment in patients with intracerebral hemorrhage. The trial is a double-blind, placebo-controlled study, and the results suggest that the Triple Pill has the potential to optimize secondary prevention.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Xia Wang, Jatinder S. Minhas, Tom J. Moullaali, Gian Luca Di Tanna, Richard Lindley, Xiaoying Chen, Hisatomi Arima, Guofang Chen, Candice Delcourt, Philip M. Bath, Joseph P. Broderick, Andrew M. Demchuk, Geoffrey A. Donnan, Alice C. Durham, Pablo M. Lavados, Tsong-Hai Lee, Christopher Levi, Sheila O. Martins, Veronica V. Olavarria, Jeyaraj D. Pandian, Mark W. Parsons, Octavio M. Pontes-Neto, Stefano Ricci, Shoichiro Sato, Vijay K. Sharma, Federico Silva, Nguyen H. Thang, Ji-Guang Wang, Mark Woodward, John Chalmers, Lili Song, Craig S. Anderson, Thompson G. Robinson
Summary: Post hoc analysis of thrombolyzed acute ischemic stroke patients showed that reducing systolic blood pressure and decreasing systolic blood pressure variability were associated with better recovery outcomes, while the magnitude of systolic blood pressure reduction did not affect the outcomes. Higher systolic blood pressure and greater systolic blood pressure variability were associated with an increased risk of intracranial hemorrhage.
Article
Clinical Neurology
Dominique A. Cadilhac, Joosup Kim, Geoffrey Cloud, Craig S. Anderson, Emma K. Tod, Sibilah J. Breen, Steven Faux, Timothy Kleinig, Helen Castley, Richard Lindley, Sandy Middleton, Bernard Yan, Kelvin Hill, Brett Jones, Darshan Shah, Katherine Jaques, Benjamin Clissold, Bruce Campbell, Natasha A. Lannin
Summary: A study conducted in Australia during the COVID-19 pandemic found that the quality of acute care for patients with stroke or transient ischemic attack has worsened, with widening care disparities between stroke units and alternate wards.
Article
Health Care Sciences & Services
Kam Cheong Wong, Tu N. Nguyen, Simone Marschner, Samual Turnbull, Mason Jenner Burns, Jia Yi Anna Ne, Vishal Gopal, Anupama Balasuriya Indrawansa, Steven A. Trankle, Tim Usherwood, Saurabh Kumar, Richard Lindley, Clara K. Chow
Summary: This study aims to examine the feasibility and effectiveness of an AF screening program using patient-led monitoring of single-lead electrocardiograms (ECGs) and clinician-coordinated central monitoring. The results will provide new information on implementing AF screening using digital health technology for older and frail populations residing in the community.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Geriatrics & Gerontology
Andrew Clegg, Karen Bandeen-Roche, Amanda Farrin, Anne Forster, Thomas M. Gill, John Gladman, Ngaire Kerse, Richard Lindley, Richard J. McManus, Rene Melis, Ruben Mujica-Mota, Parminder Raina, Kenneth Rockwood, Ruth Teh, Danielle van der Windt, Miles Witham
Summary: Meta-analyses based on individual participant data have the potential to provide more comprehensive insights into the effectiveness of interventions in aging research. However, the challenges lie in the complexity and resources needed for data collection and management. Establishing an international collaboration among trialists in aging research could facilitate the use of individual participant data meta-analysis and contribute to evidence-based care for older people.
Article
Medicine, General & Internal
Matthew J. Tanti, Melissa J. Maguire, Daniel J. Warren, John Bamford
Summary: AMACR deficiency is a rare peroxisomal disorder that causes pristanic acid accumulation. We presented a case of a female patient in her seventies who experienced dysphasia, headache, and sensory disturbance, along with unusual brain changes seen on MRI. After eight years, she developed a febrile encephalopathy with hemispheric dysfunction, focal convulsive seizures, and coma. Whole genome sequencing finally revealed the diagnosis of AMACR deficiency, with highly elevated pristanic acid levels.
Article
Rehabilitation
Ciara Shiggins, Brooke Ryan, Robyn O'Halloran, Emma Power, Julie Bernhardt, Richard I. Lindley, Gordon McGurk, Graeme J. Hankey, Miranda L. Rose
Summary: This paper highlights the issue of excluding people with aphasia from stroke research, advocates for deliberate inclusion, and provides methods and resources to support their meaningful participation.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Peripheral Vascular Disease
Lachlan L. L. Dalli, Muideen T. T. Olaiya, Joosup Kim, Nadine E. E. Andrew, Dominique A. A. Cadilhac, David Ung, Richard I. I. Lindley, Frank M. M. Sanfilippo, Amanda G. G. Thrift, Mark R. R. Nelson, Seana L. L. Gall, Monique F. F. Kilkenny, PRECISE Investigators
Summary: High adherence to antihypertensive medications within 6 months poststroke is associated with reduced risks of both major adverse cardiovascular events (MACE) and falls requiring hospitalization. Patients should be encouraged to adhere to their antihypertensive medications to maximize poststroke outcomes.
Article
Multidisciplinary Sciences
Kristina Kairaitis, Terence C. C. Amis, Rita Perri, Sharon Lee, Anne Drury, Christopher Lambeth, Paul Mitchell, Richard I. I. Lindley, John R. R. Wheatley
Summary: This study examined the relationship between obstructive sleep apnea (OSA) and retinal arteriolar and venular widening. The results showed no significant association between OSA and retinal arteriolar and venular measures.
Article
Geriatrics & Gerontology
Christopher Etherton-Beer, Amy Page, Vasi Naganathan, Kathleen Potter, Tracy Comans, Sarah N. Hilmer, Andrew J. McLachlan, Richard Lindley, Dee Mangin
Summary: This study investigated the effects of deprescribing multiple medications in older people and found that deprescribing reduced the total number of medicines used per participant. However, the impact of deprescribing on survival and other clinical outcomes remains uncertain due to the failure to meet recruitment targets.
Article
Clinical Neurology
Joanna M. Wardlaw, Lisa J. Woodhouse, Iris I. Mhlanga, Katherine Oatey, Anna K. Heye, John Bamford, Vera Cvoro, Fergus N. Doubal, Timothy England, Ahamad Hassan, Alan Montgomery, John T. O'Brien, Christine Roffe, Nikola Sprigg, David J. Werring, Philip M. Bath
Summary: The study tested the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in patients with lacunar stroke. The results showed that ISMN and cilostazol reduced recurrent stroke, dependence, and cognitive impairment, and improved quality of life, with no safety concerns. These agents could prevent other adverse outcomes in cerebral small vessel disease (cSVD) and should be tested in large phase 3 trials.
Article
Clinical Neurology
Coralie English, Emily R. Ramage, John Attia, Julie Bernhardt, Billie Bonevski, Meredith Burke, Margaret Galloway, Graeme J. Hankey, Heidi Janssen, Richard Lindley, Elizabeth Lynch, Chris Oldmeadow, Catherine M. Said, Neil J. Spratt, Karly Zacharia, Lesley MacDonald-Wicks, Amanda Patterson
Summary: This study tested the feasibility and safety of a 6-month telehealth intervention to increase physical activity and improve diet quality. The results showed that the intervention was safe and feasible and may have led to significant behavior change.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Meeting Abstract
Geriatrics & Gerontology
Jai Mehta, Richard Lindley, Caleb Ferguson, Lien Lombardo
AUSTRALASIAN JOURNAL ON AGEING
(2022)