Article
Economics
Stefan M. Scholz, Felix Weidemann, Oliver Damm, Bernhard Ultsch, Wolfgang Greiner, Ole Wichmann
Summary: The study finds that vaccinating 2 to 9-year-olds with quadrivalent influenza vaccines is cost-saving in Germany, and extending the target group to 2 to 17-year-olds can increase health benefits. Even without vaccine-induced herd protection, childhood vaccination against seasonal influenza remains cost-effective.
Review
Immunology
Yoshiyuki Sugishita, Tamie Sugawara
Summary: For elderly individuals with low incidence of influenza, calculating the credible vaccine effectiveness (VE) can be challenging. Current research shows that influenza vaccination for elderly individuals may be cost-effective, but its precise efficacy remains unclear. Studies are ongoing to determine whether influenza vaccination has a high VE for all influenza virus types, and the decreasing effect of repeated vaccination is still debated. Long-term monitoring and analysis are required to evaluate the cost-effectiveness of influenza vaccination for elderly people.
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Immunology
Coralei E. Neighbors, Evan R. Myers, Nayani P. Weerasinghe, Gaya B. Wijayaratne, Champica K. Bodinayake, Ajith Nagahawatte, L. Gayani Tillekeratne, Christopher W. Woods
Summary: Influenza vaccination is cost-effective for the Sri Lankan population, reducing cases, hospitalizations, and deaths caused by influenza. The most influential factors are vaccine coverage and effectiveness in different age groups. Providing influenza vaccines is highly cost-effective compared to not vaccinating. However, more large-scale national studies are needed to improve data and assess the impact of vaccination implementation.
Article
Economics
Pieter T. de Boer, Lisa Nagy, Franklin C. K. Dolk, Jan C. Wilschut, Richard Pitman, Maarten J. Postma
Summary: The study concludes that introducing pediatric influenza vaccination in the Netherlands is cost-saving and significantly reduces the burden of influenza-related diseases. The model suggests that adding pediatric vaccination for 2-17-year-olds to the current vaccination program for elderly and high-risk groups could lead to substantial reductions in symptomatic infections and deaths.
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Huixuan Zhou, Ningxin Ding, Xueyan Han, Hanyue Zhang, Zeting Liu, Xiao Jia, Jingjing Yu, Wei Zhang
Summary: This study evaluates the cost-effectiveness of the current COVID-19 vaccination strategy among the general population in mainland China. The findings show that vaccination reduces infection and death rates, saves healthcare costs, and is considered a cost-effective strategy.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Celeste J. Romano, Clinton Hall, Zeina G. Khodr, Anna T. Bukowinski, Gia R. Gumbs, Ava Marie S. Conlin
Summary: This study examined the association between receiving pandemic H1N1 (pH1N1) vaccines in consecutive influenza seasons and adverse pregnancy outcomes among vaccine-compliant pregnant military women. The results showed no significant association between receiving pH1N1-containing vaccine during pregnancy and spontaneous abortion or birth defects. Therefore, vaccination against pH1N1 in pregnancy is supported regardless of prior influenza season vaccination history.
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Immunology
Ellen Kim DeLuca, Acham Gebremariam, Angela Rose, Matthew Biggerstaff, Martin I. Meltzer, Lisa A. Prosser
Summary: This study aimed to evaluate the cost-effectiveness of routine annual influenza vaccination post-2009. The results showed that vaccination had an incremental cost-effectiveness ratio (ICER) lower than $95,000/QALY for all age and risk groups, except for non-high-risk working-age adults 18-49 years. Vaccination was cost-saving for adults ≥50 years at higher risk for influenza-related complications.
Article
Immunology
Ijeoma Edoka, Ciaran Kohli-Lynch, Heather Fraser, Karen Hofman, Stefano Tempia, Meredith McMorrow, Wayne Ramkrishna, Philipp Lambach, Raymond Hutubessy, Cheryl Cohen
Summary: The seasonal influenza vaccination strategy in South Africa is cost-effective for vulnerable populations, except for children aged 6-59 months. The highest number of clinical events are averted in persons living with HIV/AIDS and persons with underlying medical conditions.
Article
Immunology
Natasha S. Wenzel, Katherine E. Atkins, Edwin van Leeuwen, M. Elizabeth Halloran, Marc Baguelin
Summary: The study evaluated the cost-effectiveness of prioritizing influenza vaccination to different age groups within the 2-16 year old age range to mitigate operational and resource challenges. Vaccinating Primary School children was found to be the most cost-efficient strategy, with a higher probability of cost-effectiveness at lower willingness-to-pay levels.