Article
Multidisciplinary Sciences
Johan Malberg, Nermin Hadziosmanovic, David Smekal
Summary: The study found that COVID-19 patients had higher respiratory rates, lower tidal volume, and lower negative inspiratory pressure, which may increase the probability of having COVID-19. Additionally, an increase in respiratory rate, rapid shallow breathing index, and dead space percentage of tidal volume were associated with an increased risk of hospital admission.
Article
Medicine, General & Internal
Mattia Bellan, Lorenza Scotti, Daniela Ferrante, Elisa Calzaducca, Giulia Francesca Manfredi, Pier Paolo Sainaghi, Francesco Barone-Adesi
Summary: This study compares the risk of severe infections among different classes of biological disease-modifying anti-rheumatic drugs (bDMARDs) using administrative data. The results show that the use of Tocilizumab is associated with an increased risk of infection compared to tumor necrosis factor (TNF) inhibitor drugs, while no difference in the risk of severe infection was found for abatacept. This suggests that there are slight but important differences in the safety of different classes of bDMARDs in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Fahim Ebrahimi, Tracey G. Simon, Hannes Hagstrom, Jonas Soderling, Axel Wester, Bjorn Roelstraete, Jonas F. Ludvigsson
Summary: Patients with biopsy-proven NAFLD have a significantly higher risk of developing severe infections requiring hospitalization compared to the general population and their siblings. The risk of infection increases with the severity of NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Benjamin Lebwohl, Emma Larsson, Jonas Soderling, Bjorn Roelstraete, Joseph A. Murray, Peter H. R. Green, Jonas F. Ludvigsson
Summary: In this population-based study in Sweden, there was no significant association found between celiac disease and severe outcomes related to Covid-19. Celiac disease did not increase the risk of hospitalization for Covid-19 or severe disease, even after adjusting for comorbidities.
CLINICAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Thomas Johannesson Hjelholt, Thomas Bojer Rasmussen, Anouchka Seesaghur, Rohini K. Hernandez, Andrea Marongiu, Niels Obel, Henrik T. Toft Sorensen, A. B. Pedersen
Summary: Patients with solid cancers and bone metastases are at high risk of infections, particularly pneumonia and sepsis, which are strong predictors of death. Preventing infections in these patients is crucial for reducing mortality risk.
Article
Infectious Diseases
Lars Haukali Omland, Jacob Bodilsen, Jannik Helweg-Larsen, Jens Otto Jarlov, Morten Ziebell, Svend Ellermann-Eriksen, Ulrik Stenz Justesen, Niels Frimodt-Moller, Niels Obel
Summary: This population-based cohort study reveals that long-term functional outcomes are poor for patients with brain abscess, often leading to increased healthcare visits and higher rates of sick leave. However, these differences diminish over time, suggesting potential improvement in patients' conditions. Nonetheless, these individuals still experience permanently decreased employment rates and a higher risk of disability retirement.
JOURNAL OF INFECTION
(2022)
Article
Pharmacology & Pharmacy
Weijie Wang, Yu-Hsun Wang, Kepeng Yang, Xiangsheng Ye, Xinchang Wang, James Cheng-Chung Wei
Summary: Traditional Chinese medicine (TCM) therapy is associated with a lower risk of pneumonia in patients with systemic lupus erythematosus (SLE), especially in younger female patients. Using TCM therapy for more than 60 days significantly reduces the risk of pneumonia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Zhihua Yin, Hui-Ying Low, Brian Shiian Chen, Kuo-Shu Huang, Yue Zhang, Yu-Hsun Wang, Zhizhong Ye, James Cheng-Chung Wei
Summary: This study found a higher risk of ankylosing spondylitis (AS) in patients with endometriosis, suggesting clinicians should be aware of the occurrence of AS in patients with endometriosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Sigrun Alba Johannesdottir Schmidt, Katalin Veres, Henrik Toft Sorensen, Niels Obel, Victor W. Henderson
Summary: Based on nationwide Danish registries, this study investigated the association between herpes zoster and dementia. The results showed that there is no increased risk of dementia associated with herpes zoster, and there may even be a small decrease in risk.
Article
Immunology
Huang-Hsi Chen, Kevin Sheng-Kai Ma, Chen Dong, Wen-Jung Chang, Kuan-Rong Gao, Wuu-Tsun Perng, Jing-Yang Huang, James Cheng-Chung Wei
Summary: This study found that patients with HPV infections have a significantly higher risk of primary Sjogren's syndrome (pSS), regardless of age and sex.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shuo-Yan Gau, Pui-Ying Leong, Cheng-Li Lin, Hsi-Kai Tsou, James Cheng-Chung Wei
Summary: A retrospective cohort study using data from the Taiwan National Health Insurance database found that patients with fibromyalgia have a higher risk of developing Sjogren's syndrome compared to those without fibromyalgia, especially in the age group of 20-49 years.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Valerie M. Vaughn, Tejal N. Gandhi, Vineet Chopra, Lindsay A. Petty, Daniel L. Giesler, Anurag N. Malani, Steven J. Bernstein, Lama M. Hsaiky, Jason M. Pogue, Lisa Dumkow, David Ratz, Elizabeth S. McLaughlin, Scott A. Flanders
Summary: This study aimed to characterize antibiotic overuse after discharge among hospitalized patients treated for pneumonia or UTI, finding that nearly half of patients experienced overuse. Most of the overuse in pneumonia patients was due to excessive duration of antibiotics, while UTI patients were mainly treated for asymptomatic bacteriuria. The percentage of patients with antibiotic overuse varied significantly between hospitals and was correlated between different conditions.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
Youhyun Song, Hye Sun Lee, Goeun Park, Sang-Wook Kang, Ji Won Lee
Summary: This study aimed to investigate the risk of dyslipidemia in patients with thyroid cancer (TC) compared to the general population without TC. The results showed no significant difference in dyslipidemia risk between TC patients and the general population, both in prospective and retrospective analyses.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Houyu Zhao, Zhike Liu, Lin Zhuo, Peng Shen, Hongbo Lin, Yexiang Sun, Siyan Zhan
Summary: This study found no association between the use of sulfonylurea and cancer risk in patients with type 2 diabetes mellitus. Further studies using data from the Chinese population are needed to evaluate the association between sulfonylurea use and cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Infectious Diseases
M. H. Nguyen, R. Fornes, N. Kamau, H. Danielsson, S. Callens, E. Fransson, L. Engstrand, R. Bruyndonckx, N. Brusselaers
Summary: This study aimed to assess the impact of gestational antibiotics on the risk of preterm birth. The results showed that antibiotic use during pregnancy was associated with an increased risk of preterm birth, especially in mothers with chronic diseases.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Psychiatry
Else Foverskov, Justin S. White, Marie Norredam, Trine Froslev, Min Hee Kim, M. Maria Glymour, Lars Pedersen, Henrik T. Sorensen, Rita Hamad
Summary: This study based on refugees in Denmark found that resettling in socioeconomically disadvantaged neighborhoods increased the risk of psychiatric disorders among refugees. The results suggest that targeted placement of newly arrived refugees could help improve their mental health.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Anton Pottegard, Jacob H. Andersen, Jens Sondergaard, Reimar W. Thomsen, Tina Vilsboll
Summary: This study investigates the changes in drug usage patterns for treating type 2 diabetes in Denmark from 2005 to 2021. The results show an increase in new users of non-insulin, glucose-lowering drugs, with a peak in 2011 and a significant increase in 2020-2021. The prevalence of drug use also steadily increased over the years. General practitioners prescribed the majority of glucose-lowering drugs, and there was a notable shift in the type of drugs prescribed.
DIABETES OBESITY & METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
Soren Viborg Vestergaard, Henrik Birn, Simon Kok Jensen, Henrik Toft Sorensen, Dorothea Nitsch, Christian Fynbo Christiansen
Summary: This study aimed to investigate the incidence, histopathology, and mortality of adult nephrotic syndrome over a 24-year period. The study found a slight increase in the incidence of adult nephrotic syndrome and a significant decrease in mortality. These findings may reflect changes in epidemiology or awareness and coding of nephrotic syndrome.
Article
Public, Environmental & Occupational Health
Cecilia Hvitfeldt Fuglsang, Istvan Bakos, Kristina Laugesen, Frederikke Schonfeldt Troelsen, Erzsebet Horvath-Puho, Henrik Toft Sorensen
Summary: This population-based cohort study in Denmark investigated the association between smoking during pregnancy and the risk of appendicitis in offspring. The results showed a slightly higher hazard rate for children of smoking mothers compared to nonsmokers. The association may be mediated by later-life exposures.
Article
Education & Educational Research
Kala M. Mehta, Karin Lottrup Petersen, Steve Goodman, Henrik Toft Sorensen, Martin Bogsted, Jeppe Dorup Olesen, Sylvia Burks, Richard E. Shaw, Jens Dahlgaard Hove, Jakob Ousager, Carlos Milla, Vibeke Andersen, Niels Ejskjaer, Vibeke Brix-Christensen, Shomit Ghose, Andreas Kjaer, Peter V. Chin-Hong
Summary: The Danish-American Research Exchange (DARE) program provides Danish medical students with the opportunity to collaborate and conduct biomedical research with US medical institutions. This program enhances students' research skills and interdisciplinary thinking, and encourages exploration of low-cost healthcare interventions. Analysis of the research outcomes and intentions of DARE alumni suggests that this medical student-initiated research model has positive effects on promoting binational collaboration in medicine.
BMC MEDICAL EDUCATION
(2023)
Article
Gastroenterology & Hepatology
Frederikke Schonfeldt Troelsen, Henrik Toft Sorensen, Lars Pedersen, Lone Dragnes Brix, Louise Bang Grode, Evelien Dekker, Rune Erichsen
Summary: This study investigated the plausible explanations for post-colonoscopy colorectal cancer (PCCRC) in a Danish Region using the World Endoscopy Organization algorithm, finding that most PCCRCs originate from possible missed lesions and incompletely resected lesions. These findings underscore the importance of quality assurance of colonoscopy procedures and polypectomy techniques.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ola Olen, Karin E. Smedby, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Asa Hallqvist-Everhov, Johan SWIBREG Study Grp, Johan Askling, Anders Ekbom, Michael C. Sachs, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Earlier studies on lymphoma risk in patients with inflammatory bowel disease (IBD) have provided varying estimates, but have been limited by detection biases, misclassification, and small sample sizes. Our binational cohort study found that the risk of lymphoma has increased in Crohn's disease (CD) patients over the past 20 years, but not in ulcerative colitis (UC) patients. The increase in risk was mainly driven by T-cell lymphomas and aggressive B-cell lymphomas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Anne Gedebjerg, Mette Bjerre, Alisa Devedzic Kjaergaard, Jens Steen Nielsen, Jorgen Rungby, Ivan Brandslund, Michael Maeng, Henning Beck-Nielsen, Allan Vaag, Henrik Toft Sorensen, Troels Krarup Hansen, Reimar Wernich Thomsen
Summary: We investigated the relationship between hs-CRP and C-peptide in patients with recently diagnosed T2D and found that high levels of hs-CRP were associated with increased risk of CVEs and all-cause mortality. Patients with high levels of both biomarkers had the highest risk. These findings have important implications for early detection and prevention of deadly diseases beyond CVEs.
Article
Clinical Neurology
Lotte Sahin Levison, Reimar Wernich Thomsen, Henning Andersen
Summary: A population-based study in Denmark found that patients with Guillain-Barre syndrome (GBS) had a 7.6-fold increased risk of depression in the first two years after hospital admission compared to the general population, but the risk was similar after two years.
Article
Endocrinology & Metabolism
N. R. Gadgaard, C. Varnum, R. G. H. H. Nelissen, C. Vandenbroucke-Grauls, H. T. Sorensen, A. B. Pedersen
Summary: The impact of comorbidity on infection risk among hip fracture patients is not clear, but a high incidence of infection was found. Comorbidity was identified as an important risk factor for infection up to 1 year after surgery. The results indicate a need for increased investment and support for patients with high comorbidity in pre- and postoperative programs.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Morten Schmidt, Lars Arendt-Nielsen, Ellen-Margrethe Hauge, Henrik Toft Sorensen, Lars Pedersen
Summary: This study investigated the dose dependency of diclofenac's cardiovascular risks by using Danish health registries and a target trial emulation design. The results showed that both high-dose and low-dose diclofenac users had a similar increased risk of cardiovascular events compared to non-users. This finding challenges the assumption that low-dose diclofenac is risk-neutral.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Anne Cathrine Baun Thuesen, Rasmus Tanderup Jensen, Henrik Maagensen, Maja Refshauge Kristiansen, Henrik Toft Sorensen, Allan Vaag, Henning Beck-Nielsen, Oluf B. Pedersen, Niels Grarup, Jens Steen Nielsen, Jorgen Rungby, Anette Prior Gjesing, Heidi Storgaard, Tina Vilsboll, Torben Hansen
Summary: This study investigated the glycemic phenotype and treatment response of patients with type 2 diabetes carrying rare GCK variants consistent with GCK-diabetes. Carriers of pathogenic and likely pathogenic variants had lower fasting glucose and C-peptide levels. Stopping medication did not lead to worsening of HbA1c or fasting glucose. Variants of uncertain significance should be interpreted carefully.
MOLECULAR GENETICS AND METABOLISM REPORTS
(2023)
Correction
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Jazmine Abril, Britton Trabert, Rebecca Troisi, Tom Grotmol, Anders Ekbom, Anders Engeland, Mika Gissler, Ingrid Glimelius, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Steinar Tretli, Tone Bjorge
Summary: This study examines the risk factors for uterine sarcoma and compares them with MMMTs and type I endometrial carcinomas. The results show that risk factors vary substantially between uterine sarcoma and MMMTs.
CANCER CAUSES & CONTROL
(2023)
Article
Clinical Neurology
Holly Elser, Erzsebet Horvath-Puho, Jaimie L. Gradus, Meghan L. Smith, Timothy L. Lash, M. Maria Glymour, Henrik Toft Sorensen, Victor W. Henderson
Summary: Late-life depressive symptoms are associated with subsequent dementia diagnosis and may be an early symptom or response to preclinical disease. Evaluating associations with early- and middle-life depression will help clarify whether depression influences dementia risk.