Article
Endocrinology & Metabolism
Yun You, Haofei Hu, Changchun Cao, Yong Han, Jie Tang, Weihua Zhao
Summary: The study found that the TG/HDL-C ratio in the first trimester is associated with the onset of GDM in pregnant women. The results suggest that measuring the TG/HDL-C ratio can help identify pregnant women at risk for GDM and enable them to receive early and effective treatment to improve prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ren Zhang, Kezhong Zhang
Summary: Research on ANGPTL proteins, particularly the role of A8 expression in the liver and WAT, in TG partitioning has shown to be crucial for regulating LPL activity, which varies during fed and fasting cycles.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Management
Arthur Charpentier, Stephane Mussard, Tea Ouraga
Summary: The Gini PCA, based on the generalized Gini correlation index, is proposed as a method for robust dimensionality reduction that is shown to be equivalent to standard PCA in the Gaussian case. Monte Carlo simulations and application on cars data demonstrate the robustness and different interpretations of results compared to variance PCA.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2021)
Article
Mathematics, Applied
Baishuai Zuo, Chuancun Yin
Summary: This paper considers the multivariate tail covariance (MTCov) for generalized skew-elliptical distributions and explores some special cases, such as generalized skew-normal, generalized skew student-t, generalized skew-logistic, and generalized skew-Laplace distributions. The theoretical feasibility of the results is tested by computing and comparing the MTCov for skewed and non-skewed normal distributions. A special formula for the MTCov of generalized skew-elliptical distributions is provided.
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS
(2022)
Article
Genetics & Heredity
Michal Marczyk, Agnieszka Macioszek, Joanna Tobiasz, Joanna Polanska, Joanna Zyla
Summary: The study evaluated the impact of different integration methods and linkage disequilibrium correction on multiple GSA algorithms, with CERNO and MAGENTA combined with Stouffer method showing the most efficiency. LD correction increased prioritization and specificity of enrichment outcomes for all tested algorithms. The best performance was observed when using Fisher or Stouffer integration with LD correction.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Health Care Sciences & Services
Anita Brobbey, Samuel Wiebe, Alberto Nettel-Aguirre, Colin Bruce Josephson, Tyler Williamson, Lisa M. Lix, Tolulope T. Sajobi
Summary: This study investigates the accuracy of repeated measures discriminant analysis (RMDA) based on the multivariate generalized estimating equations (GEE) framework for classification in multivariate repeated measures designs with the same or different types of responses repeatedly measured over time. RMDA based on GEE exhibited higher average classification accuracy than RMDA based on maximum likelihood estimators (MLE) especially in multivariate non-normal distributions.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Genetics & Heredity
Yu-Huang Liao, Leay-Kiaw Er, Semon Wu, Yu-Lin Ko, Ming-Sheng Teng
Summary: The study revealed a significant association between LIPC variants and HDL-C levels, with the H2: CTA haplotype being significantly related to HDL-C levels and the H1: TCG haplotype suppressing HDL-C levels in the presence of TG. The findings suggest a suppressive role for TG in the genome-wide association between LIPC and HDL-C, indicating that a functional haplotype of hepatic lipase may reduce HDL-C levels and is suppressed by TG.
Article
Endocrinology & Metabolism
Daniel Nyarko Hukportie, Fu-Rong Li, Rui Zhou, Jia-Zhen Zheng, Xiao-Xiang Wu, Meng-Chen Zou, Xian-Bo Wu
Summary: Lipid variability is associated with the risk of microvascular complications in patients with type 2 diabetes mellitus. High-density lipoprotein cholesterol (HDL-C), triglyceride, and remnant cholesterol (RC) variability are associated with an increased risk of nephropathy and neuropathy, but not retinopathy.
JOURNAL OF DIABETES
(2022)
Review
Cardiac & Cardiovascular Systems
Kyung An Kim, Na Jin Kim, Eun-Ho Choo
Summary: This meta-analysis aimed to evaluate the effect of fibrate treatment on cardiovascular risk. It found that fibrate therapy was associated with decreased risk of major adverse cardiovascular outcomes (MACE), primarily through the reduction of low-density lipoprotein cholesterol (LDL-C) rather than triglyceride levels.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Jun Watanabe, Masato Hamasaki, Kazuhiko Kotani
Summary: Eradication of Helicobacter pylori increases HDL-C levels and triglyceride levels, but does not significantly affect low-density lipoprotein-cholesterol levels. Further studies are needed to clarify the effects of lipid changes following H. pylori eradication on cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Chunyan Zhao, Yueqi Wang, Liu Xiao, Lin Li
Summary: The results of this meta-analysis suggest that levothyroxine treatment may reduce total cholesterol, triglycerides, low-density lipoprotein cholesterol, and apolipoprotein B levels in older patients with subclinical hypothyroidism (SCH). However, it does not significantly affect bone mineral density, fatigue, hypothyroidism symptoms, quality of life, body mass index, cognitive function, depression, blood pressure, or increase the incidence of adverse events in older SCH patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Psychiatry
Veni Bharti, Aseem Bhardwaj, Kalli Hood, David A. Elias, Arron W. S. Metcalfe, Jong Sung Kim
Summary: This meta-analysis reviewed 29 studies comparing lipid levels in MDD patients and healthy individuals, finding higher TG levels but lower TC and VLDL levels in MDD patients. Age and region were found to have an impact on lipid levels in MDD patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Xiaoxian Gong, Luowei Chen, Bo Song, Xiang Han, Weihai Xu, Bo Wu, Feng Sheng, Min Lou
Summary: The study found that an increase in total cholesterol and triglycerides is associated with an increased risk of ischemic stroke and a reduced risk of hemorrhagic stroke, while an increase in high-density lipoprotein cholesterol is associated with a reduced risk of ischemic stroke. It is recommended to control total cholesterol and low-density lipoprotein cholesterol levels within certain ranges.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Genetics & Heredity
Xin (Cynthia) Ye, Nicole M. Roslin, Andrew D. Paterson, Christopher J. Lyons, Victor Pegado, Phillip Richmond, Casper Shyr, Oriol Fornes, XiaoHua Han, Michelle Higginson, Colin J. Ross, Deborah Giaschi, Cheryl Gregory-Evans, Millan S. Patel, Wyeth W. Wasserman
Summary: This study investigates the genetic basis of isolated strabismus in a seven-generation family and identifies a linkage signal on chromosome 14q12. Through next-generation sequencing and bioinformatic analysis, a 4 bp non-coding deletion is identified as a top candidate for the observed strabismus phenotype. This finding provides insights into the regulation of FOXG1 and sheds light on the mechanisms underlying strabismus and FOXG1 syndrome.
JOURNAL OF MEDICAL GENETICS
(2022)