Article
Geriatrics & Gerontology
Fereshteh Moradoghli, Ali Darvishpoor Kakhki, Roghayeh Esmaeili
Summary: Frailty is associated with decreased dignity in older adults, with frailty being the leading predictor of dignity. Providers should develop programs to prevent and reduce frailty in those at risk and enhance the dignity of already frail individuals.
Article
Geriatrics & Gerontology
L. M. Gutierrez-Robledo, R. E. Garcia-Chanes, E. Gonzalez-Bautista, O. Rosas-Carrasco
Summary: This study aimed to compare short and long versions of an intrinsic capacity index and found that both versions performed well in assessing functional status, helping classify older adults and being associated with relevant health outcomes.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Marcel A. L. M. van Assen, Judith H. M. Helmink, Robbert J. J. Gobbens
Summary: This study aims to determine the association between lifestyle factors (smoking, alcohol use, nutrition, physical activity) and multidimensional frailty. The results showed that higher alcohol consumption, physical activity, healthy nutrition, and less smoking were associated with lower levels of frailty. Physical activity had the greatest impact on frailty.
Article
Health Care Sciences & Services
Yuto Kiuchi, Hyuma Makizako, Yuki Nakai, Kazutoshi Tomioka, Yoshiaki Taniguchi, Mika Kimura, Hiroaki Kanouchi, Toshihiro Takenaka, Takuro Kubozono, Mitsuru Ohishi
Summary: There is a significant association between diet variety and physical frailty in older adults, particularly a strong correlation between low Food Frequency Score and physical frailty.
Article
Clinical Neurology
Jennifer L. Guida, Alfonso J. Alfini, Lisa Gallicchio, Adam P. Spira, Neil E. Caporaso, Paige A. Green
Summary: The study found that actigraphy-measured sleep quality was significantly associated with risk of frailty and mortality over a 5-year period among community-dwelling older adults. Sleep fragmentation index, wake after sleep onset, and percent sleep were found to be significantly correlated with frailty and mortality.
Article
Geriatrics & Gerontology
Yanxia Lu, Crystal Tze Ying Tan, Xinyi Gwee, Keng Bee Yap, Tamas Fulop, Fang Pan, Anis Larbi, Tze Pin Ng
Summary: The study found that a high pathogen load is associated with gait speed, functional mobility, cognitive function, and frailty index, as well as with inflammatory biomarker levels. Blood biomarkers did not fully explain the observed association between pathogen load and functional aging measures.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Joaquin Barrachina-Igual, Francisco M. Martinez-Arnau, Pilar Perez-Ros, Cristina Flor-Rufino, Roberto Sanz-Requena, Ana Pablos
Summary: This study evaluated the effect of the PROMUFRA program on pre-frail, community-dwelling older people, showing it to be effective in improving muscle mass, functional performance, and other variables. The program consisted of a 12-week multi-component exercise plan, with significant differences found in muscle function and overall health outcomes.
Article
Medicine, General & Internal
Yanxia Lu, Wee Shiong Lim, Xia Jin, Ma Schwe Zin Nyunt, Tamas Fulop, Qi Gao, Su Chi Lim, Anis Larbi, Tze Pin Ng
Summary: Dysregulated insulin secretion may play an important role in age-related and diabetes-related sarcopenia.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Toshiko Tanaka, Sameera A. Talegawkar, Yichen Jin, Julian Candia, Qu Tian, Ruin Moaddel, Eleanor M. Simonsick, Luigi Ferrucci
Summary: Diet quality is associated with aging rates. This study identified metabolomic biomarkers of dietary patterns and explored their role in mediating the relationship between diet and healthy aging. Adherence to different dietary patterns was associated with lower frailty index. Multiple metabolite classes were associated with different dietary patterns, suggesting common mechanisms underlying the relationship between diet and frailty. These metabolites may serve as biomarkers for poor diet quality.
Article
Geriatrics & Gerontology
Claudio Pedone, Antonio De Vincentis, Federica Quarata, Stefania Bandinelli, Luigi Ferrucci, Raffaele Antonelli Incalzi
Summary: The study aimed to evaluate whether the addition of other biological and social variables to the frailty phenotype (FP) could improve the prediction of declining functional ability in community-dwelling older people. A scoring system was derived and validated using data from two studies, including FP components, age, perceived health status, and socio-economic disadvantage markers. The results showed that this scoring system was able to predict the declining functional ability in older adults.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Medicine, General & Internal
Hee-Won Jung, Ji Yeon Baek, Il-Young Jang, Eunju Lee
Summary: This study aimed to assess the characteristics and validities of the Clinical Frailty Scale (CFS) in community-dwelling older people in Korea using the original classification tree (oCFS) and a culturally modified tree (mCFS). The results showed that the correlation coefficients with frailty index were higher in mCFS than in oCFS, and the classification coefficient of mCFS was significantly higher than that of oCFS in determining people with frailty. Therefore, the culturally modified CFS classification tree is considered valid in detecting the vulnerable population in the community-dwelling older people in Korea.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Masamitsu Sugie, Kazumasa Harada, Marina Nara, Yoshihiro Kugimiya, Tetsuya Takahashi, Moe Kitagou, Hunkyung Kim, Shunei Kyo, Hideki Ito
Summary: This study aims to explore the prevalence and overlap of physical, cognitive, psychological, and social frailty among the elderly population, and identify factors that may help reduce frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Endocrinology & Metabolism
Adam Mitchell, Linnea Malmgren, Patrik Bartosch, Fiona Elizabeth McGuigan, Kristina E. Akesson
Summary: A longitudinal proteomics study identified proteins associated with frailty, particularly the transition from nonfrail to frail. Eight core proteins (CD4, FGF23, Gal-9, PAR-1, REN, TNFRSF10A, TNFRSF11A, and TNFRSF10B) were proposed as candidates for understanding the development and progression of frailty. Measuring protein expression and changes associated with frailty can provide insights into the underlying mechanisms of frailty.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Shuli Jia, Wanyu Zhao, Yan Zhang, Lisha Hou, Xin Xia, Runjuan Qiao, Jirong Yue, Birong Dong
Summary: The study uncovered an association between multiple physical symptoms and frailty in older adults, with musculoskeletal symptoms being the most prevalent. Multiple symptoms within the same organ system may have a greater impact on frailty compared to counting total symptoms. Even when covariates were controlled, significant relationships were found between musculoskeletal and cardiopulmonary symptoms with frailty.
Article
Nutrition & Dietetics
Asuka Tani, Shinsuke Mizutani, Hiro Kishimoto, Saori Oku, Kiyomi Iyota, Tianshu Chu, Xin Liu, Haruhiko Kashiwazaki
Summary: Decline in oral function in older people is related to nutritional deficiencies, increasing frailty risk and need for nursing care. This study compared the effectiveness of delivering an oral function improvement program through a tablet device versus a paper-based program. The association between improvement in tongue pressure and nutritional status at baseline was also investigated.
Article
Psychiatry
Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suarez, Minerva Crespo Ramirez, Vilma Carolina Bekker-Mendez, M. Magdalena Aguirre-Garcia, Sandra Angelica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Perez de la Mora
Summary: Tryptophan hydroxylase type 2 (Tph2) is crucial in serotonin (5-HT) biosynthesis, and its dysfunction may lead to 5-HT deficiency. Research has linked polymorphisms of the TPH2 gene to suicidal behavior, while 5-HT deficiency has been associated with various psychiatric pathologies. Therefore, further studies are needed to explore the potential application of TPH2 gene in psychiatric diseases involving Tph2 dysfunction or serotonin deficiency.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Lourdes Balcazar-Hernandez, Lourdes Basurto, Leticia Manuel-Apolinar, Sara Vega-Garcia, Norma Basurto-Acevedo, Carlos Martinez-Murillo, Rosalinda Sanchez-Arenas
Summary: This study identified associations between various adipokines, myokines, osteokines, hepatokines, and inflammatory cytokines with body size phenotype, BMI, VAT, and HOMA-IR in middle-aged women. Elevation of OCN and reduction of adiponectin were associated with a metabolic unhealthy phenotype in normal weight women, while higher irisin and MCP-1 were risk factors for a metabolic unhealthy phenotype in women with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 could potentially serve as biomarkers for an unhealthy metabolic phenotype in middle-aged women.
Article
Chemistry, Medicinal
Fernando Calzada, Elihu Bautista, Sergio Hidalgo-Figueroa, Normand Garcia-Hernandez, Claudia Velazquez, Elizabeth Barbosa, Miguel Valdes, Jesus Ivan Solares-Pascasio
Summary: Incomptines A and B are sesquiterpene lactones with various biological activities. IB showed stronger antibacterial activity against Vibrio cholerae compared to IA, while IA had a more significant impact on the action of cholera toxin. IA also exhibited higher anti-diarrheal activity than IB and the positive control racercadotril.
Article
Biochemistry & Molecular Biology
Fernando Calzada, Normand Garcia-Hernandez, Sergio Hidalgo-Figueroa, Elihu Bautista, Elizabeth Barbosa, Claudia Velazquez, Marta Elena Hernandez-Caballero
Summary: Heliangolide-type sesquiterpene lactones (HTSLs) have cytotoxic and antitumor activity and may serve as potential candidates for the development of new leukemia treatments.
Article
Neurosciences
Norma A. Estrada-Cruz, Leticia Manuel-Apolinar, Julia J. Segura-Uribe, Julio C. Almanza-Perez, Angeles Fortis-Barrera, Sandra Orozco-Suarez, Guadalupe Bautista-Poblet, Angelica Coyoy-Salgado, Christian Guerra-Araiza
Summary: Inflammation and oxidative stress play important roles in neurodegeneration. High-calorie diets, menopause, and aging can increase the risk of neurodegeneration. Hormone replacement therapy can alleviate menopause symptoms, and short-term administration of the synthetic hormone Tibolone can reduce oxidative stress and inflammation caused by a high-fat and fructose diet.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Alberto J. Mimenza-Alvarado, Maria J. Suing-Ortega, Teresa Tusie-Luna, Teresa Juarez-Cedillo, Jose A. Avila-Funes, Sara G. Aguilar-Navarro
Summary: This study found an association between APOE-epsilon(4) carrier status and qualitative changes on MRI (medial temporal and parietal atrophy), as well as detection of white matter hyperintensities (WMH) in older adults with MCI.
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2022)
Review
Cell Biology
Miguel Perez de la Mora, Dasiel O. Borroto-Escuela, Minerva Crespo-Ramirez, Jose del Carmen Rejon-Orantes, Daniel Alejandro Palacios-Lagunas, Magda K. Martinez-Mata, Daniela Sanchez-Luna, Emiliano Tesoro-Cruz, Kjell Fuxe
Summary: Major depressive disorder (MDD) and anxiety are highly prevalent mental diseases with negative impacts on society and patients. Finding effective treatments with limited side effects is an important goal. This review focuses on the role of G-protein coupled receptors (GPCRs), such as serotonin, dopamine, galanin, and opioid heteroreceptor complexes, in regulating synaptic transmission in the limbic networks of the brain, and how understanding these mechanisms can contribute to the development of new treatments for MDD and anxiety disorders.
Article
Neurosciences
Teresa Juarez-Cedillo, Evangelina Gonzelez-Figueroa, Lidia Gutierez-Gutierez, Sara G. Aguilar-Navarro, Juan Carlos Garcia-Cruz, Jorge Escobedo de la Pena, Alan Suerna-Hernandez
Summary: This study estimates the prevalence and types of dementia among elderly people living in the community in Mexico City. The findings indicate a relatively high prevalence of dementia in Mexico, especially Alzheimer's disease. The prevalence of dementia is higher in women than in men. These results provide evidence for the development of early diagnosis and care strategies in the region.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Abrahan Hernandez-Hernandez, Tayde Lopez-Santaella, Aranxa Torres-Caballero, Amarantha Serrato, Ulises Torres-Flores, Diego Montesinos-Valencia, Fernando Chico-Ponce De Leon, Vicente Gonzalez-Carranza, Samuel Torres-Garcia, Rosa Rebollar-Vega, Inti Alberto De la Rosa-Velazquez, Rosario Ortiz, Monserrat Perez-Ramirez, Normand Garcia-Hernandez, Antonio Garcia-Mendez, Francisco Arenas-Huertero
Summary: Central nervous system tumors are common in childhood and contribute to cancer-related mortality. This study explored the transcriptomic landscape of pediatric astrocytoma, focusing on the genetic alterations associated with tumorigenesis. The findings provide insights into the biological functions and pathways involved in astrocytoma, and establish a transcriptional signature for identifying different grades of the tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Teresa Juarez-Cedillo, Nancy Martinez-Rodriguez, Gilberto Vargas-Alarcon, Enrique Juarez-Cedillo, Antonio Valle-Medina, Osvaldo Garrido-Acosta, Alfredo Ramirez
Summary: Neuroinflammation plays an important role in certain types of dementia. This study found that gene-gene interaction models can be used to identify populations susceptible to dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Heriberto Santander-Lucio, Armando Totomoch-Serra, Maria de Lourdes Munoz, Normand Garcia-Hernandez, Gerardo Perez-Ramirez, Adan Valladares-Salgado, Ashael Alfredo Perez-Munoz
Summary: This study analyzes the association between 18 mitochondrial DNA variants and type 2 diabetes and related metabolic traits in a Mexican mestizo population. The results show a strong association between the m.315_316insC variant and type 2 diabetes, as well as nominal associations with certain metabolic traits.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Neurosciences
Teresa Juarez-Cedillo, Nancy Martinez-Rodriguez, Jose Manuel Fragoso, Valentin Islas-Perez, Amara Lopez-Martinez, Antonio Valle-Medina
Summary: This study aimed to evaluate the association between single-nucleotide polymorphism (SNP) in the dopamine β-hydroxylase (DBH) gene (rs1611115) and their interactions with environmental factors and the risk of dementia. The interaction and impact of DBH (rs1611115) polymorphism on dementia were examined using multifactor dimensionality reduction (MDR) analysis, and the results were verified by the Chi-square test. The results showed that the TT genotype of the DBH1 locus rs1611115 TT was positively correlated with diabetes, hypertension, and alcohol consumption, leading to further cognitive damage.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Angel Giovanni Arietta-Garcia, Fernando Calzada, Israel Ramirez-Sanchez, Elihu Bautista, Normand Garcia-Hernandez, Rosa Maria Ordonez-Razo
Summary: This study found that Incomptine A (IA) exhibits cytotoxic activity against breast cancer cells of triple negative, HER2+, and luminal A subtypes. IA shows higher cytotoxic activity in cancer cells compared to non-tumorigenic cells, with a selectivity index higher than doxorubicin. It is suggested that IA could reactivate apoptosis in breast cancer cells by binding to Hexokinase II (HKII) and reducing its expression, making it a potential therapeutic agent for breast cancer treatment across multiple subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Rosalinda Posadas-Sanchez, Hector Gonzalez-Pacheco, Alexandra Arias -Mendoza, Galileo Escobedo, Teresa Juarez-Cedillo, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: This study found that ABO gene polymorphisms are associated with a lower risk of ACS, lower systolic blood pressure, and plasma lipid levels.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Primary Health Care
Sarahi Estrella Maldonado-Paredes, Teresa Juarez-Cedillo, Jorge Escobedo de la Pena, Miguel Angel Vaca-Marin, Carolina Quinones-Villalobos, Osvaldo Garrido-Acosta, Roberto C. Gonzalez-Melendez
Summary: This study developed and validated a new tool to measure satisfaction with integral care of type 2 diabetes mellitus patients, with four domains including communication, empathy, technical care, and care continuity. The results demonstrated reliability and validity of the tool, providing insights for improving the relationship between healthcare providers and patients.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2022)