Article
Endocrinology & Metabolism
Jose Luis Perez-Castrillon, Antonio Duenas-Laita, Carlos Gomez-Alonso, Esteban Jodar, Javier del Pino-Montes, Maria Luisa Brandi, Fernando Cereto Castro, Jose Manuel Quesada-Gomez, Laura Gallego Lopez, Jose Manuel Olmos Martinez, Maria Rosa Alhambra Exposito, Bernat Galarraga, Jesus Gonzalez-Macias, Jose Luis Neyro, Roger Bouillon, Gonzalo Hernandez-Herrero, Nieves Fernandez-Hernando, Sandra P. Chinchilla
Summary: This report presents the results of a 1-year clinical trial comparing the efficacy and safety of monthly calcifediol and cholecalciferol in postmenopausal women with vitamin D deficiency. The study found that monthly calcifediol is an effective and safe treatment, maintaining stable vitamin D levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Ana Arnanz, Juan A. Garcia-Velasco, Jose Luis Neyro
Summary: The vitamin D endocrine system plays a crucial role in human fertility, and its deficiency can be related to various reproductive issues. This deficiency has been linked to in vitro fertilization outcomes, ovarian reserve and fertility, and endocrine disorders such as polycystic ovary disease. It may also be associated with uterine fibroids and pregnancy-related complications. The optimal dose of vitamin D supplementation for infertility or during pregnancy is still uncertain, and further clinical studies are needed to determine its benefits and appropriate dosage.
Review
Nutrition & Dietetics
Jose-Luis Perez-Castrillon, Ricardo Usategui-Martin, Pawel Pludowski
Summary: Calcifediol is the prohormone of the vitamin D endocrine system, used to prevent and treat vitamin D deficiency. It is more efficient and safe than cholecalciferol, with a rapid onset of action and greater potency. The increase in 25-OH vitamin D depends on the dose and frequency of calcifediol administration, while cholecalciferol administration is influenced by additional factors such as obesity and malabsorption.
Article
Endocrinology & Metabolism
Jose Luis Perez-Castrillon, Antonio Duenas-Laita, Maria Luisa Brandi, Esteban Jodar, Javier del Pino-Montes, Jose Manuel Quesada-Gomez, Fernando Cereto Castro, Carlos Gomez-Alonso, Laura Gallego Lopez, Jose Manuel Olmos Martinez, Maria Rosa Alhambra Exposito, Bernat Galarraga, Jesus Gonzalez-Macias, Roger Bouillon, Gonzalo Hernandez-Herrero, Nieves Fernandez-Hernando, Paula Arranz-Gutierrez, Sandra P. Chinchilla
Summary: This study confirms the efficacy of calcifediol compared to cholecalciferol in raising serum 25-hydroxyvitamin D levels, presenting itself as a faster and more potent option for the treatment of vitamin D deficiency.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Review
Food Science & Technology
Sanjay Kumar Dey, Shashank Kumar, Diksha Rani, Shashank Kumar Maurya, Pratibha Banerjee, Madhur Verma, Sabyasachi Senapati
Summary: Clinical, epidemiological, and molecular studies have highlighted the importance of vitamin D in human health and wellbeing. Vitamin D deficiency has become a global public health concern, with high prevalence in different ethnic populations. Clinical studies have shown the relevance of vitamin D screening and supplementation in improving health conditions. Recent research suggests a broader role of vitamin D in different disease pathologies, including cardiovascular and immune diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Christian Mingiano, Tommaso Picchioni, Guido Cavati, Filippo Pirrotta, Marco Calabrese, Ranuccio Nuti, Stefano Gonnelli, Alberto Fortini, Bruno Frediani, Luigi Gennari, Daniela Merlotti
Summary: This study aimed to evaluate the relationship between 25-OH vitamin D (25OHD) levels and prognosis, mortality, mechanical ventilation, and orotracheal intubation in hospitalized COVID-19 patients. The study found a positive correlation between 25OHD levels and oxygenation levels, and significantly lower levels in patients requiring mechanical ventilation and intubation. Patients with severe 25OHD deficiency had longer hospital stays and higher mortality rates. Additionally, supplementation with calcifediol reduced hospitalization duration and mortality rates.
Article
Biochemistry & Molecular Biology
Roger Bouillon, Jose Manuel Quesada Gomez
Summary: Vitamin D deficiency affects a significant portion of the world's population, with 7% having severe deficiency and one third having mild deficiency. This study compares the effectiveness of calcifediol or 25-hydroxyvitamin D (25OHD) versus vitamin D itself in preventing or treating deficiency. Calcifediol has higher absorption rates, is immediately accessible to the circulation, and is more potent than vitamin D, especially in cases of fat malabsorption or after bariatric surgery. It may be a preferred option for correcting deficiency in individuals with impaired liver 25-hydroxylase activity.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Review
Medicine, General & Internal
Davaasambuu Ganmaa, Davaasambuu Enkhmaa, Erdenebileg Nasantogtokh, Surenmaa Sukhbaatar, Khash-Erdene Tumur-Ochir, J. E. Manson
Summary: Current evidence from RCTs and meta-analyses of RCTs is inconsistent regarding the effects of vitamin D supplementation on respiratory infections and chronic diseases. Individuals most likely to benefit are those with baseline VDD or with selected high-risk conditions.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Yuxiong Chen, Siqin Feng, Zhen'ge Chang, Yakun Zhao, Yanbo Liu, Jia Fu, Yijie Liu, Siqi Tang, Yitao Han, Shuyang Zhang, Zhongjie Fan
Summary: This study examined the association between serum vitamin D levels and mortality in patients with nonalcoholic fatty liver disease (NAFLD), finding that higher levels of 25(OH)D were independently associated with reduced risk of all-cause and cardiovascular deaths.
Review
Biology
Marcello Izzo, Albino Carrizzo, Carmine Izzo, Enrico Cappello, Domenico Cecere, Michele Ciccarelli, Patrizia Iannece, Antonio Damato, Carmine Vecchione, Francesco Pompeo
Summary: Vitamin D plays a crucial role in the treatment of osteoporosis and is also believed to have potential implications in cardiovascular and metabolic diseases. Studies have shown associations between vitamin D and conditions like diabetes, atherosclerosis, and hypertension, highlighting the need for further research to understand its role in these diseases.
Article
Immunology
Renwei Lu, Ziqi Peng, Panpan Lian, Junaid Wazir, Chaode Gu, Chujun Ma, Lulu Wei, Li Li, Wenyuan Pu, Jun Liu, Hongwei Wang, Zhonglan Su
Summary: This study found that vitamin D has a significant therapeutic effect in the treatment of atopic dermatitis, possibly by inhibiting the phosphorylation of STAT3, reducing inflammatory cell infiltration and chemokine release, decreasing AQP3 protein expression, and inhibiting cell proliferation to restore the skin barrier function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Grubler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried Marz, Stefan Pilz, Stephanie Gangler
Summary: This post hoc analysis investigated the effects of vitamin D on blood pressure and found that vitamin D supplementation did not have an antihypertensive effect in individuals with vitamin D deficiency. However, there was a significant association between achieved 25(OH)D concentrations and blood pressure.
Review
Biochemistry & Molecular Biology
Alfonso Rodriguez-Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Perez-Simon
Summary: Vitamin D plays a dual role in the immune system and tumor cells, potentially decreasing graft-versus-host disease and relapse rates.
Article
Health Care Sciences & Services
Kevin Fiscella, Hua He, Mechelle Sanders, Andrea Cassells, Jennifer K. Carroll, Stephen K. Williams, Jerry Cornell, Tameir Holder, Chamanara Khalida, Jonathan N. Tobin
Summary: The intervention aimed at shortening follow-up time for patients with uncontrolled hypertension did not show significant improvement, but resulted in statistically and clinically relevant improvement in hypertension control.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Letter
Primary Health Care
Kevin Fiscella
Article
Medicine, General & Internal
Jeffrey P. Yaeger, Jiahao Lu, Jeremiah Jones, Ashkan Ertefaie, Kevin Fiscella, Daniel Gildea
Summary: The study aimed to develop a natural language processing algorithm to identify febrile infants and compare its performance to diagnostic codes. Results showed that the algorithm had higher sensitivity and specificity, accurately identifying febrile infants.
JOURNAL OF HOSPITAL MEDICINE
(2022)
Article
Medicine, General & Internal
Carolyn Sufrin, Camille T. Kramer, Mishka Terplan, Kevin Fiscella, Sarah Olson, Kristin Voegtline, Carl Latkin
Summary: This study assessed the availability of medications for opioid use disorder (MOUD) for pregnant individuals with opioid use disorder (OUD) in US jails. The results showed that although most jails continued to provide medication for individuals who were receiving treatment before incarceration, few jails initiated MOUD and most medication-providing jails discontinued MOUD during the postpartum period.
Article
Urology & Nephrology
Alexis R. Steinmetz, Jacob Gantz, Kevin Fiscella, Edward M. Messing
Summary: This study aimed to use an implementation science framework to increase the rates of postoperative intravesical chemotherapy with gemcitabine in patients with low-grade, nonmuscle-invasive bladder cancer, thereby improving the quality of cancer care.
Article
Dentistry, Oral Surgery & Medicine
H. Alzamil, T. T. Wu, E. van Wijngaarden, M. Mendoza, H. Malmstrom, K. Fiscella, D. T. Kopycka-Kedzierawski, R. J. Billings, J. Xiao
Summary: This study found that wearing removable dentures is a risk predictor for increased pneumonia incidence among older adults, even after adjusting for other risk factors. Clinicians and older patients can refer to these study results when choosing dental prostheses to restore missing teeth.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2023)
Editorial Material
Emergency Medicine
Kevin Fiscella, Debra A. Pinals, Cleveland G. Shields
ACADEMIC EMERGENCY MEDICINE
(2022)
Article
Primary Health Care
Mechelle Sanders, Colleen T. Fogarty, Christopher P. Morley, Stephen Schultz, Mathew Devine, Soumya B. Sridhar, Kevin Fiscella
Summary: This study aimed to understand the incorporation and extent of public health interventions training in family medicine residency programs amid the COVID-19 pandemic. The findings showed that all programs provided some level of training, and there were no significant differences in training intensity between university and nonuniversity affiliates. The biggest barrier identified was the need to allocate time to other curriculum requirements.
Article
Health Care Sciences & Services
Fahad Saeed, Susan Ladwig, Rebecca Jane Allen, Nwamaka D. Eneanya, Manjula Kurella Tamura, Kevin A. Fiscella
Summary: This study investigated racial disparities in prognostic discussions, beliefs about future health, and completion of advance care planning (ACP)-related documents among Black and White patients receiving maintenance dialysis. The results showed that there were differences in health expectations and completion of ACP-related documents between Black and White patients. Therefore, systemic efforts are needed to investigate differences in health beliefs and address racial disparities in the completion of ACP-related documents.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Letter
Health Care Sciences & Services
Fahad Saeed, Amaka Eneanya, Rebecca J. Allen, Manjula K. Tamura, Kevin A. Fiscella
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Kevin Fiscella, Ronald M. Epstein
Summary: Currently, the definition of health in healthcare is limited and biomedical-focused. A national conversation is needed to establish a holistic definition of health that can drive healthcare transformation and achieve equity. This can be achieved through federal leadership, intersectoral collaborations, changes in medical education, and the implementation of high-quality primary care.
Article
Urology & Nephrology
Basil S. S. Kazi, Paul R. R. Duberstein, Benzi M. M. Kluger, Ronald M. M. Epstein, Kevin A. A. Fiscella, Zain S. S. Kazi, Spencer K. K. Dahl, Rebecca J. J. Allen, Fahad Saeed
Summary: This study investigated the prevalence and correlates of preference-concordant care among hospitalized people receiving dialysis. The results showed that a substantial proportion of the sample reported not receiving preference-concordant care. Efforts to improve symptom management and enhance patient engagement in dialysis decision-making may improve patients' perceptions of receiving preference-concordant care.
Article
Medicine, General & Internal
Jeffrey P. Yaeger, Kevin A. Fiscella, Ashkan Ertefaie, Amina P. Alio
JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Reza Yousefi Nooraie, Gretchen Roman, Kevin Fiscella, James M. McMahon, Elissa Orlando, Nancy M. Bennett
Summary: This study aimed to analyze the distribution, clustering, and recognition of dissemination and implementation (D&I) expertise in an academic institution. The results showed that many health researchers have D&I expertise but do not identify themselves as D&I researchers. This highlights the importance of identifying and engaging unrecognized clusters of D&I expertise in academic settings to promote interdisciplinary collaboration and build capacity for D&I.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Urology & Nephrology
Fahad Saeed, Haris F. Murad, Richard E. Wing, Jianbo Li, Jesse D. Schold, Kevin A. Fiscella
Summary: Patients receiving maintenance dialysis experience high mortality following in-hospital CPR, and only 10% are discharged home.