Article
Multidisciplinary Sciences
Selena E. Richards, Chandana Wijeweera, Albert Wijeweera
Summary: The objective of this study was to investigate the global socioeconomic risk factors associated with diabetes prevalence. The results showed that diabetes prevalence was closely associated with per capita income, tobacco consumption, and alcohol consumption. Factors such as overweight prevalence, gross national income, and unemployment rates were positively associated with diabetes prevalence, while total population size, unemployment rates, and alcohol consumption were inversely associated with diabetes prevalence. These findings provide important evidence for the development of global policies to combat diabetes.
Review
Biology
Jibran A. Wali, Samantha M. Solon-Biet, Therese Freire, Amanda E. Brandon
Summary: Obesity and overweight are widespread issues linked to insulin resistance and various diseases; nutrition plays a key role in metabolic health, but effective dietary interventions for long-term compliance are lacking.
Review
Biochemistry & Molecular Biology
Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi
Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Federica Biello, Francesca Platini, Francesca D'Avanzo, Carlo Cattrini, Alessia Mennitto, Silvia Genestroni, Veronica Martini, Paolo Marzullo, Gianluca Aimaretti, Alessandra Gennari
Summary: Breast cancer and host metabolism are closely related, with insulin playing a role in promoting tumor growth through various pathways, while metformin's anti-cancer mechanisms involve lowering insulin levels and direct impact on cancer cell signaling pathways. Obesity, metabolic syndrome, and insulin resistance are all implicated in breast cancer growth and prognosis, potentially linked to a pro-inflammatory state and cytokines originating from fat tissue.
Review
Endocrinology & Metabolism
Armel H. H. Nwabo Kamdje, Paul F. Seke Etet, Maulilio J. Kipanyula, Lorella Vecchio, Richard Tagne Simo, Alfred K. Njamnshi, Kiven E. Lukong, Patrice N. Mimche
Summary: The tumor microenvironment plays a role in tumorigenesis and drug resistance through the overexpression of insulin-like growth factor 1 (IGF-1). Anti-IGF therapies have shown potential in inhibiting cancer and overcoming chemotherapy drug resistance in preclinical studies, but toxicity and resistance are challenges in clinical trials.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Archana Arjunan, Dhiraj Kumar Sah, Minna Woo, Juhyun Song
Summary: Neurodegenerative disorders are characterized by neuronal degeneration and glial dysfunction, leading to impairments in cognition, psychomotor function, and behavior. Metabolic syndrome has been linked to these disorders, and insulin growth factor-1 (IGF-1) deficiency has been associated with MetS-related pathologies. IGF-1 plays a crucial role in neurogenesis, plasticity, angiogenesis, and metabolic function in the brain, making it a potential therapeutic target for MetS-related neurodegenerative diseases. This review highlights the evidence for the potential therapeutic effects of IGF-1 and its involvement in molecular signaling defects in MetS-related neurodegeneration.
CELL AND BIOSCIENCE
(2023)
Article
Oncology
Mauro De Santi, Giosue Annibalini, Giuseppe Marano, Giacomo Biganzoli, Elisabetta Venturelli, Massimo Pellegrini, Francesco Lucertini, Giorgio Brandi, Elia Biganzoli, Elena Barbieri, Anna Villarini
Summary: This study analyzed the association between IGF-1 levels and metabolic syndrome and insulin resistance in breast cancer survivors. The results showed that circulating IGF-1 levels were lower in subjects with metabolic syndrome, and insulin was the main predictor of elevated IGF-1 levels in subjects without metabolic syndrome. There was also an interaction between HDL-C, glycemia, and IGF-1 levels, particularly in subjects with higher glycemia values and without a diagnosis of metabolic syndrome.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Article
Multidisciplinary Sciences
Saara Laine, Tanja Sjoros, Taru Garthwaite, Maria Saarenhovi, Petri Kallio, Eliisa Loyttyniemi, Henri Vaha-Ypya, Harri Sievanen, Tommi Vasankari, Kirsi Laitinen, Noora Houttu, Ekaterina Saukko, Juhani Knuuti, Virva Saunavaara, Ilkka H. A. Heinonen
Summary: This study aimed to investigate the relationship between liver fat content (LFC) and sedentary behavior (SB), physical activity (PA), fitness, diet, body composition, and cardiometabolic risk factors in adults with metabolic syndrome. The results showed that LFC was positively associated with body fat and various cardiometabolic risk factors, and negatively associated with daily protein intake. SB, PA, or fitness were not independent modulators of LFC, but PA may indirectly affect liver health through its effects on body composition in adults with metabolic syndrome.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Review
Endocrinology & Metabolism
Wentao Zhong, Xueqing Wang, Yufei Wang, Guoqian Sun, Jia Zhang, Zhuo Li
Summary: Obesity is a global epidemic and a risk factor for endocrine-related cancers. It affects insulin, IGF-1, sex hormones, IGFBPs, and adipokines, with IGF-1 playing a crucial role in obesity-related endocrine cancers. This review discusses the impact of obesity on prostate, breast, and pancreatic cancers, focusing on the mechanism of IGF-1 and its interaction with estrogen and adipokines. Additionally, the current status of IGF-1R inhibitors in clinical practice and their potential combination with other anticancer drugs are briefly introduced.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aldona Kasprzak
Summary: Colorectal cancer is a common aggressive carcinoma with poor prognosis, often associated with metabolic syndrome and high blood sugar levels. The role of IGF-1 in glucose metabolism in colorectal carcinogenesis and its potential link to the Warburg effect require further investigation. Current therapeutic strategies targeting impaired glucose metabolism in CRC are being explored to improve treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Elizabeth A. Szamreta, Bo Qin, Zorimar Rivera-Nunez, Niyati Parekh, Emily S. Barrett, Jeanne Ferrante, Yong Lin, Elisa Bandera
PUBLIC HEALTH NUTRITION
(2020)
Review
Public, Environmental & Occupational Health
Jacqueline Litvak, Niyati Parekh, Andrea Deierlein
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2020)
Article
Oncology
Grace Lu-Yao, Ginah Nightingale, Nikita Nikita, Scott Keith, Krupa Gandhi, Kristine Swartz, Ralph Zinner, Swapnil Sharma, W. M. Kevin Kelly, Andrew Chapman
JOURNAL OF GERIATRIC ONCOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Enai Ojeda, Christian Torres, Angela Carriedo, Melissa Mialon, Niyati Parekh, Emanuel Orozco
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2020)
Editorial Material
Public, Environmental & Occupational Health
Niyati Parekh, Andrea L. Deierlein
PUBLIC HEALTH NUTRITION
(2020)
Article
Nutrition & Dietetics
Maya K. Vadiveloo, Haley W. Parker, Filippa Juul, Niyati Parekh
Article
Nutrition & Dietetics
Niyati Parekh, Yong Lin, Melany Chan, Filippa Juul, Nour Makarem
Summary: This study found that drinking patterns are unstable throughout adulthood, with higher alcohol intake generally associated with poorer diets. Understanding the impact of drinking patterns on diet and health can provide valuable insights into alcohol consumption and reducing adverse health effects.
BRITISH JOURNAL OF NUTRITION
(2021)
Editorial Material
Public, Environmental & Occupational Health
Shahmir H. Ali, Ralph J. DiClemente, Niyati Parekh
Summary: South Asian immigrants face a growing burden of non-communicable diseases, especially second-generation communities that are underserved and understudied. More research and data collection are needed to understand behavioral and cultural patterns that contribute to disease onset and progression among this population. Expanding research on second-generation South Asian migrant health may help develop tailored interventions.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Bridget Murphy, Sameera A. Talegawkar, Joyce O'Connor, Namratha R. Kandula, Alka M. Kanaya, Matthew A. Allison, Niyati Parekh
Summary: The study found that dairy intake among South Asian adults in the USA is associated with certain measures of body composition, with higher consumption of low-fat yogurt linked to lower visceral and intermuscular fat areas, and higher dairy intake in women associated with lower waist circumference. Milk and cheese consumption, however, showed no significant associations with body composition measures.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Oncology
Chun Wang, Zhenchao Zhang, Weelic Chong, Rui Luo, Ronald E. Myers, Jian Gu, Jianqing Lin, Qiang Wei, Bingshan Li, Timothy R. Rebbeck, Grace Lu-Yao, William K. Kelly, Hushan Yang
Summary: This study investigated the associations of CTCs and CTC-clusters with mCRPC prognosis using longitudinal samples, finding that CTC counts were associated with mCRPC outcomes, and the presence of CTC-clusters alone had prognostic value, improving CTC-based prognostic stratification. The findings suggest the potential of combining CTC and CTC-clusters as non-invasive means to monitor progression and predict survival in mCRPC.
Article
Nutrition & Dietetics
Filippa Juul, Yong Lin, Andrea L. Deierlein, Georgeta Vaidean, Niyati Parekh
Summary: This study found a decrease in consumption of ultraprocessed foods and minimally processed foods in the American population over a 17-year period, with overall improvement in diet quality. The results emphasize the need for public health efforts to limit the consumption of ultraprocessed foods due to their poor nutritional quality.
BRITISH JOURNAL OF NUTRITION
(2021)
Review
Endocrinology & Metabolism
Soohyun Nam, Stephanie Griggs, Garrett Ash, Genevieve F. Dunton, Shuyuan Huang, Janene Batten, Niyati Parekh, Robin Whittemore
Summary: This systematic review aimed to summarize the EMA methodology and its associations with psychosocial, contextual factors, and diabetes self-management. The study found that psychological stress was associated with increased calorie intake, while specific time periods were linked to different self-management behaviors.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Filippa Juul, Georgeta Vaidean, Yong Lin, Andrea L. Deierlein, Niyati Parekh
Summary: The study found that higher consumption of ultra-processed foods is associated with an increased risk of cardiovascular disease incidence and mortality, suggesting potential cardiovascular benefits of limiting ultra-processed foods.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Oncology
Shivanshu Awasthi, Brandon A. Mahal, Jong Y. Park, Jordan H. Creed, Vonetta L. Williams, Asmaa Elkenawi, Sylvester O. Meadows, Julio M. Pow-Sang, Grace Lu-Yao, Wm. Kevin Kelly, Damaris-Lois Y. Lang, Janice Zgibor, Timothy R. Rebbeck, Kosj Yamoah
Summary: Evidence suggests that Black men with low-risk prostate cancer may have a higher risk of Gleason score reclassification compared to White men, particularly in extreme reclassification. Additionally, the time to treatment can non-linearly impact Gleason reclassification in Black men.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Meeting Abstract
Psychology, Multidisciplinary
Shahmir H. Ali, Supriya Misra, Niyati Parekh, Bridget Murphy, Ralph J. DiClemente
ANNALS OF BEHAVIORAL MEDICINE
(2020)