Article
Physiology
Jinelle Gelinas, Megan Harper, John Sasso, Stephen Wright, Bernie Melzer, Gloria Agar, Jordan Guenette, Gregory duManoir, Michael Roman, J. Douglass Rolf, Neil Eves
Summary: This study investigated the integrative exercise responses associated with different exercise limitation phenotypes in COPD patients. The results showed that the cardiovascular phenotype had less static hyperinflation, lower end-expiratory lung volume, and larger tidal volume during exercise compared to other phenotypes. The cardiovascular phenotype also showed higher peak ventilation, cardiopulmonary fitness, and maximum workload compared to the ventilatory phenotype. Categorizing COPD patients phenotypically may aid in optimizing exercise prescription for rehabilitation purposes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Elisabetta Zampogna, Nicolino Ambrosino, Federico Mattia Oliva, Monica Rudi, Giovanni Sotgiu, Laura Saderi, Antonio Spanevello, Dina Visca
Summary: This study evaluated the impact of pulmonary rehabilitation on heart rate recovery (HRR) in individuals with asthma compared to those with COPD. The findings showed that individuals with asthma had a lower prevalence of slow HRR than those with COPD. However, exercise training significantly improved exercise capacity in both populations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shishir Rao, Milad Nazarzadeh, Yikuan Li, Dexter Canoy, Mohammad Mamouei, Gholamreza Salimi-Khorshidi, Kazem Rahimi
Summary: A cohort study investigated the association between systolic blood pressure (SBP) and risk of cardiovascular events in patients with chronic obstructive pulmonary disease (COPD), revealing a monotonic relationship between SBP and cardiovascular event risk.
Article
Critical Care Medicine
Mihaela S. Stefan, Penelope S. Pekow, Aruna Priya, Richard ZuWallack, Kerry A. Spitzer, Tara C. Lagu, Quinn R. Pack, Victor M. Pinto-Plata, Kathleen M. Mazor, Peter K. Lindenauer
Summary: Initiating pulmonary rehabilitation within 90 days of discharge can reduce the risk of rehospitalization for COPD patients among Medicare beneficiaries. These findings support results from randomized controlled clinical trials and emphasize the importance of identifying effective strategies to increase participation in pulmonary rehabilitation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Lucas A. Gillenwater, Shahab Helmi, Evan Stene, Katherine A. Pratte, Yonghua Zhuang, Ronald P. Schuyler, Leslie Lange, Peter J. Castaldi, Craig P. Hersh, Farnoush Banaei-Kashani, Russell P. Bowler, Katerina J. Kechris
Summary: This study used transcriptomics, proteomics, and metabolomics to explore the clinical heterogeneity of Chronic Obstructive Pulmonary Disease (COPD), identifying clusters of COPD patients with distinct clinical characteristics. Integrating these different -omics datasets offers additional insight into the molecular nature of COPD and its heterogeneity.
Review
Physiology
Bingzhi Zhang, Peijun Li, Jian Li, Xiaodan Liu, Weibing Wu
Summary: Oxidative stress is a main factor causing diaphragm dysfunction in COPD, while exercise plays a positive role in preventing and improving this dysfunction. The effects of exercise on oxidative stress and diaphragm function depend on the intensity, duration, and style of exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Katrina O. Tonga, Brian G. Oliver
Summary: Chronic obstructive pulmonary disease (COPD) is a complex and serious disease with various physical and psychological manifestations. Pulmonary rehabilitation, including exercise, is an effective intervention for COPD. However, the efficacy of non-traditional forms of exercise in alternative medicine remains poorly understood. This study aims to fill this knowledge gap and provide a summary of the clinical evidence for traditional exercise regimens in the pulmonary rehabilitation of COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Stan R. W. Wijn, Maroeska M. Rovers, Gerjon Hannink
Summary: Researchers commonly use propensity score matching (PSM) to adjust for confounding in longitudinal observational data, but inappropriate use of PSM was found in 25% of studies with a time-varying treatment. While methods designed for time-varying treatment and confounding are available, they were only utilized in 45% of the studies.
Article
Hematology
Peter G. Miller, Dandi Qiao, Joselyn Rojas-Quintero, Michael C. Honigberg, Adam S. Sperling, Christopher J. Gibson, Alexander G. Bick, Abhishek Niroula, Marie E. McConkey, Brittany Sandoval, Brian C. Miller, Weiwei Shi, Kaushik Viswanathan, Matthew Leventhal, Lillian Werner, Matthew Moll, Brian E. Cade, R. Graham Barr, Adolfo Correa, L. Adrienne Cupples, Sina A. Gharib, Deepti Jain, Stephanie M. Gogarten, Leslie A. Lange, Stephanie J. London, Ani Manichaikul, George T. O'Connor, Elizabeth C. Oelsner, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Vasan Ramachandran, Bing Yu, Lynette Sholl, Donna Neuberg, Siddhartha Jaiswal, Bruce D. Levy, Caroline A. Owen, Pradeep Natarajan, Edwin K. Silverman, Peter van Galen, Yohannes Tesfaigzi, Michael H. Cho, Benjamin L. Ebert
Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.
Article
Medicine, General & Internal
Michele Vitacca, Mara Paneroni, Beatrice Salvi, Antonio Spanevello, Piero Ceriana, Claudio Bruschi, Bruno Balbi, Maria Aliani, Nicolino Ambrosino
Summary: This study suggests that the success rate of pulmonary rehabilitation (PR) is not affected by airflow severity and outcome measures in individuals with severe COPD recovering from exacerbation. In addition to the commonly used outcome measures, Barthel dyspnoea index and Short Physical Performance Battery are also sensitive to PR.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Physics, Multidisciplinary
Silke Klemm, Lucrezia Ravera
Summary: In this paper, we discuss homogeneous and heterogeneous SIR-type epidemiological models. Surprisingly, we discover a correspondence between the epidemic trajectory in a homogeneous SIR-type model and radial null geodesics in the Schwarzschild spacetime. We also explore population heterogeneity effects by examining the initial susceptibility distribution and deriving the herd immunity threshold, and propose a method to incorporate mitigation measures through model fitting.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Medicine, General & Internal
Akito Miyazaki, Keisuke Miki, Ryoji Maekura, Kazuyuki Tsujino, Hisako Hashimoto, Mari Miki, Hiromi Yanagi, Taro Koba, Takuro Nii, Takanori Matsuki, Hiroshi Kida
Summary: This study found that pulmonary rehabilitation (PR) can increase peak oxygen uptake (V' (O2)) and improve exercise tolerance and ventilatory efficiency in patients with COPD. The improvement in oxygen extraction ability correlated with the difference in peak V' (O2) and ventilatory efficiency, suggesting that a new strategy for improving oxygen extraction ability may be effective in patients with limited ventilatory ability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Respiratory System
Vishanna Balbirsingh, Andrea S. Mohammed, Alice M. Turner, Michael Newnham
Summary: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular disease (CVD), and the relationship between the two involves shared risk factors, pathophysiology, high prevalence, adverse effects of COPD, and medication interactions. Improved diagnosis and treatment could lead to better outcomes for COPD patients with CVD, which is often underdiagnosed.
Article
Respiratory System
Sara De Matteis, Debbie Jarvis, Lucy Darnton, Dario Consonni, Hans Kromhout, Sally Hutchings, Steven S. Sadhra, David Fishwick, Roel Vermeulen, Lesley Rushton, Paul Cullinan
Summary: This large population-based study found an association between occupational exposure to pesticides and risk of COPD. The risk was particularly pronounced among non-smokers and individuals without asthma.
Article
Cardiac & Cardiovascular Systems
Zach Rozenbaum, Yanai Ben-Gal, Livia Kapusta, Aviram Hochstadt, Ben Sadeh, Galit Aviram, Ofer Havakuk, Jason Shimiaie, Michael Ghermezi, Michal Laufer-Perl, Yacov Shacham, Gad Keren, Yan Topilsky
Summary: The study found that exercise intolerance in COPD patients is mainly due to issues related to cardiac function, hemodynamics, and peripheral oxygen extraction, rather than simply obstructive lung function. In addition, chronic heart failure, restricted stroke volume, exercise-induced elevation in left filling pressure, and peripheral factors were identified as common problems in COPD patients.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Review
Geriatrics & Gerontology
Simon U. Jaeger, Martin Wohlrab, Daniel Schoene, Roman Tremmel, Michael Chambers, Letizia Leocani, Solange Corriol-Rohou, Jochen Klenk, Basil Sharrack, Judith Garcia-Aymerich, Lynn Rochester, Walter Maetzler, Milo Puhan, Matthias Schwab, Clemens Becker
Summary: This study evaluated the use of mobility as a decisive outcome for the marketing authorisation of drugs by the European Medicines Agency (EMA). The study found that there was little consideration given to mobility assessment for conditions with a high impact on mobility in the marketing authorisation process.
Article
Environmental Sciences
Subhabrata Moitra, Maria Foraster, Ane Arbillaga-Etxarri, Alicia Marin, Anael Barberan-Garcia, Diego A. Rodriguez-Chiaradia, Eva Balcells, Maria Koreny, Pere Toran-Monserrat, Pere Vall-Casas, Robert Rodriguez-Roisin, Judith Garcia-Aymerich
Summary: The study found that increased air pollution, particularly NO2 and PM2.5absorbance, and greater distances to blue/green spaces negatively influence health-related quality of life in COPD patients.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Alicia Abellan, Sara M. Mensink-Bout, Raquel Garcia-Esteban, Andrea Beneito, Leda Chatzi, Talita Duarte-Salles, Mariana F. Fernandez, Judith Garcia-Aymerich, Berit Granum, Carmen Iniguez, Vincent W. V. Jaddoe, Kurunthachalam Kannan, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Claire Philippat, Amrit K. Sakhi, Susana Santos, Valerie Siroux, Jordi Sunyer, Leonardo Trasande, Marina Vafeiadi, Fernando Vela-Soria, Tiffany C. Yang, Carlos Zabaleta, Martine Vrijheid, Liesbeth Duijts, Maribel Casas
Summary: This study found that in utero exposure to BPA may increase the odds of asthma and wheeze in school-age girls. The associations of BPF and BPS with respiratory outcomes were inconsistent in overall and sex-stratified analyses.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Anna Stapleton, Maribel Casas, Judith Garcia, Raquel Garcia, Jordi Sunyer, Stefano Guerra, Alicia Abellan, Iris Lavi, Carlota Dobano, Marta Vidal, Mireia Gascon
Summary: The study revealed that prenatal exposure to PM10 and PMcoarse had consistent associations with reduced lung function, while associations with postnatal exposure were less consistent. An increase in CC16 levels at age 4 was associated with improved lung function, but no significant associations were found between air pollution and CC16.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Giulia Squillacioti, Anne-Elie Carsin, Valeria Bellisario, Roberto Bono, Judith Garcia-Aymerich
Summary: Residential greenness exposure has a positive impact on health by reducing oxidative stress in children, and physical activity does not mediate this association.
ENVIRONMENTAL RESEARCH
(2022)
Article
Psychiatry
X. Goldberg, G. Castano-Vinyals, A. Espinosa, A. Carreras, L. Liutsko, E. Sicuri, M. Foraster, C. O'Callaghan-Gordo, P. Dadvand, G. Moncunill, C. Dobano, B. Cortes, V Pleguezuelos, K. Straif, J. Garcia-Aymerich, R. de Cid, E. Cardis, M. Kogevinas
Summary: This study examined the factors related to depression and anxiety after the first outbreak in Spain. The findings showed that pre-existing mental health conditions were associated with the severity of COVID-19 disease and increased risk of severe depression and anxiety. Among those without prior mental health disorders, post-lockdown depression and anxiety were associated with household interpersonal conflicts and financial instability.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Respiratory System
Subhabrata Moitra, Anne-Elie Carsin, Michael J. Abramson, Simone Accordini, Andre F. S. Amaral, Josep Anto, Roberto Bono, Lidia Casas Ruiz, Isa Cerveri, Leda Chatzi, Pascal Demoly, Sandra Dorado-Arenas, Bertil Forsberg, Frank Gilliland, Thorarinn Gislason, Jose A. Gullon, Joachim Heinrich, Mathias Holm, Christer Janson, Rain Jogi, Francisco Gomez Real, Debbie Jarvis, Benedicte Leynaert, Dennis Nowak, Nicole Probst-Hensch, Jose Luis Sanchez-Ramos, Chantal Raherison-Semjen, Valerie Siroux, Stefano Guerra, Manolis Kogevinas, Judith Garcia-Aymerich
Summary: This study is the first to show that adults with asthma have a higher risk of developing obesity compared to those without asthma, especially among non-atopic individuals, those with longer disease duration, or those taking oral corticosteroids.
Article
Geriatrics & Gerontology
Remi Gontie, Judith Garcia-Aymerich, Julia Jubany, Marina Bosque-Prous, Tivy Baron-Garcia, Helena Gonzalez-Casals, Gemma Drou-Roget, Anna Beringues, Albert Espelt
Summary: This study analysed the relationship between physical activity and the incidence of dementia in people aged 50 years or older without dementia in Europe. The results showed that frequent moderate physical activity is independently associated with a lower risk of dementia. The study also found that the risk of dementia is higher in individuals who rarely or never engage in moderate-to-vigorous physical activity.
AGING & MENTAL HEALTH
(2023)
Article
Critical Care Medicine
Stefano Guerra, Julie G. Ledford, Erik Melen, Iris Lavi, Anne-Elie Carsin, Debra A. Stern, Jing Zhai, Marta Vidal, Mariona Bustamante, Kenneth J. Addison, Renata G. Vallecillo, Dean Billheimer, Gerard H. Koppelman, Judith Garcia-Aymerich, Nathanael Lemonnier, Montserrat Fito, Carlota Dobano, Simon Kebede Merid, Inger Kull, Rosemary R. C. McEachan, John Wright, Leda Chatzi, Manolis Kogevinas, Daniela Porta, Silvia Narduzzi, Ferran Ballester, Ana Esplugues, Carlos Zabaleta, Amaia Irizar, Jordi Sunyer, Marilyn Halonen, Jean Bousquet, Fernando D. Martinez, Josep M. Anto
Summary: A study was conducted to screen circulating proteins in childhood asthma and investigate their association with the disease in a mouse model. It was found that creatine kinase (CK) was consistently associated with asthma, and this association was further supported by gene expression analysis and a mouse model experiment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Osama Mahmoud, Raquel Granell, Gabriela P. Peralta, Judith Garcia-Aymerich, Deborah Jarvis, John Henderson, Jonathan Sterne
Summary: This study found that maternal perinatal BMI, birthweight, childhood lean and fat mass, and early-onset asthma were the most important factors influencing lung function in early adulthood.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Geriatrics & Gerontology
Laura Delgado-Ortiz, Ashley Polhemus, Alison Keogh, Norman Sutton, Werner Remmele, Clint Hansen, Felix Kluge, Basil Sharrack, Clemens Becker, Thierry Troosters, Walter Maetzler, Lynn Rochester, Anja Frei, Milo A. Puhan, Judith Garcia-Aymerich
Summary: This study examined the personal experiences of individuals living with walking impairment and identified seven themes describing the walking experience across different health conditions. A novel conceptual framework was proposed to guide patient-centered clinical practice, research, and public health.
Article
Environmental Sciences
Alberto Ruano-Ravina, Orlando Acosta, David Diaz Perez, Ciro Casanova, Valle Velasco, German Peces-Barba, Esther Barreiro, Ana Canas, Argelia Castano, Maria Jesus Cruz Carmona, Carmen Diego, Judith Garcia-Aymerich, Cristina Martinez, Maria Molina-Molina, Xavier Munoz, Francisco Javier Sanchez-Inigo, Cristina Candal-Pedreira
Summary: This study aims to assess the short-, medium-, and long-term respiratory health effects of exposure to volcanic emissions from the eruption in different population groups. The study will employ multiple designs, including a cohort study on the general population, highly exposed population, and childhood population, as well as a pre-post quasi-experimental study on subjects with previously diagnosed respiratory diseases. Information will be collected through personal interviews, biologic specimens, air pollution data, and medical records, among other methods, with a planned follow-up of five years.
ENVIRONMENTAL RESEARCH
(2023)
Editorial Material
Public, Environmental & Occupational Health
Josep M. Anto, Neil Pearce, Jeroen Douwes, Judith Garcia-Aymerich, Lucy Pembrey, Lorenzo Richiardi, Jordi Sunyer
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Respiratory System
Anne-Elie Carsin, Judith Garcia-Aymerich, Simone Accordini, Shyamali Dharmage, Benedicte Leynaert, Marti de las Heras, Lidia Casas, Seraina Caviezel, Pascal Demoly, Bertil Forsberg, Thorarinn Gislason, Angelo Guido Corsico, Christer Janson, Rain Jogi, Jesus Martinez-Moratalla, Dennis Nowak, Leopoldo Palacios Gomez, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison-Semjen, Giulia Squillacioti, Cecilie Svanes, Kjell Toren, Isabel Urrutia, Ismael Huerta, Josep Maria Anto, Debbie Jarvis, Stefano Guerra
Summary: This study aimed to describe the characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Data from the European Community Respiratory Health Survey (ECRHS) were used, and longitudinal assessments of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were conducted.
Article
Health Care Sciences & Services
Joren Buekers, Ane Arbillaga-Etxarri, Elena Gimeno-Santos, David Donaire-Gonzalez, Guillaume Chevance, Jean-Marie Aerts, Judith Garcia-Aymerich
Summary: This study aimed to determine if wearable devices could provide valid heart rate (HR) and oxygen uptake (V?O-2) kinetics during outdoor walks in patients with chronic obstructive pulmonary disease (COPD). The results showed that continuous measurements with wearable devices provided valid HR and V?O-2 kinetics, which were comparable to laboratory-based tests.
