期刊
ANNALS OF DERMATOLOGY
卷 25, 期 2, 页码 135-144出版社
KOREAN DERMATOLOGICAL ASSOC
DOI: 10.5021/ad.2013.25.2.135
关键词
Melanoma; Metastasis; TGF-beta signaling; Therapeutic-targets
类别
Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-beta signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-beta is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-beta signaling in melanoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据