Article
Microbiology
Rowena Alves Coelho, Maria Helena Galdino Figueiredo-Carvalho, Fernando Almeida-Silva, Vanessa Brito de Souza Rabello, Gabriela Rodrigues de Souza, Leandro Stefano Sangenito, Luna Sobrino Joffe, Andre Luis Souza dos Santos, Maria Cristina da Silva Lourenco, Marcio L. Rodrigues, Rodrigo Almeida-Paes
Summary: This study discovered substances with antifungal activity against CBM agents from a collection of drugs previously approved for use in human diseases, and benzimidazoles showed the highest selectivity.
Article
Dermatology
Armando Guevara, Andreia Ferreira Nery, Marcia de Souza Carvalho Melhem, Lucas Bonfietti, Anderson Messias Rodrigues, Ferry Hagen, Jamile Ambrosio de Carvalho, Zoilo Pires de Camargo, Bruna Jacomel F. de Souza Lima, Vania Aparecida Vicente, Rosane Christine Hahn
Summary: Chromoblastomycosis primarily affects the poor population in Brazil, especially those involved in agricultural activities, with F. pedrosoi being the main etiological agent. Itraconazole, voriconazole, and terbinafine showed the highest antifungal activity.
Article
Immunology
Lucas de Oliveira Las-Casas, Clara Luna Freitas Marina, Raffael Junio Araujo de Castro, Luisa Coutinho Coelho, Sonia Nair Bao, G. Sybren de Hoog, Vania Aparecida Vicente, Larissa Fernandes, Anamelia Lorenzetti Bocca
Summary: This study demonstrated for the first time that different species of Fonsecaea produce extracellular vesicles (EVs) in response to nutritional conditions, and these EVs can modulate the production of pro- and anti-inflammatory cytokines and nitric oxide by bone marrow-derived macrophages (BMDMs). The size, content, and morphology of the EVs were also affected by growth conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Clare Logan, Manuraj Singh, Natalya Fox, Gordon Brown, Sreedhar Krishna, Kristiana Gordon, Derek Macallan, Tihana Bicanic
Summary: Chromoblastomycosis (CBM) is a chronic fungal infection of the skin and subcutaneous tissue that is difficult to treat. The lack of standardized therapeutic approach and limited evidence for treatment options contribute to its chronicity. This case study presents a successful treatment of a chronic CBM lesion of the hand using a combination of posaconazole and topical imiquimod, an immune response modifier. The clinical and histopathological improvement of the lesion was demonstrated, suggesting the potential of antifungal therapy with adjunctive immunotherapy for CBM.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Luisa Dan Favilla, Tatiana Sobianski Herman, Camila da Silva Goersch, Rosangela Vieira de Andrade, Maria Sueli Soares Felipe, Anamelia Lorenzetti Bocca, Larissa Fernandes
Summary: This study successfully generated a novel mutant of the dematiaceous fungal genus Fonsecaea by gene deletion and homologous recombination. The mutant showed differences in nutrient supply, viability, and growth compared to the wild-type and reconstituted strains. These findings contribute to a better understanding of the biology and pathogenicity of chromoblastomycosis causative agents.
Review
Microbiology
Leandro C. D. Breda, Isabela G. Menezes, Larissa N. M. Paulo, Sandro Rogerio de Almeida
Summary: Chromoblastomycosis (CBM) is a chronic and progressive subcutaneous mycosis caused by different species of fungi from the Herpotrichiellaceae family, often associated with agricultural activities. The economic challenges in treatment, lack of specific therapy, and potential for immunotherapeutic approaches make CBM a complex disease requiring further research and innovative treatment strategies.
Article
Infectious Diseases
Sujun Liu, Huilin Zhi, Hong Shen, Wenwen Lv, Bo Sang, Qiuping Li, Yan Zhong, Zehu Liu, Xiujiao Xia
Summary: This study reports the clinical aspects of chromoblastomycosis (CBM) in Eastern China based on a series of 11 cases from 2018 to 2021. The majority of patients were male, and the duration of the disease varied from 3 months to 20 years. Plaque type lesions were the most common clinical manifestation, and most cases were successfully cured.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Hongfang Liu, Jiufeng Sun, Minying Li, Wenying Cai, Yangxia Chen, Yinghui Liu, Huan Huang, Zhenmou Xie, Weiying Zeng, Liyan Xi
Summary: This study investigated the epidemiological, clinical, and laboratory characteristics of CBM in Guangdong, China. The findings revealed that CBM patients were mostly elderly with a long duration of the disease and a higher prevalence in males. The most common clinical manifestation was the verrucous form. Antifungal susceptibility tests showed low minimum inhibitory concentrations for certain drugs. Combination therapy with itraconazole and terbinafine was commonly used for treatment. Cytokine profile analysis indicated impaired immune response in CBM cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Ingrid S. Sousa, Thais P. Mello, Elaine P. Pereira, Marcela Q. Granato, Celuta S. Alviano, Andre L. S. Santos, Lucimar F. Kneipp
Summary: Patients with chromoblastomycosis (CBM) suffer from chronic tissue lesions that are difficult to treat. It has been found that CBM fungi are capable of forming biofilms, which interact with macrophages and exhibit higher resistance to conventional antifungal drugs.
Review
Infectious Diseases
Armando Guevara, Nathan Pereira Siqueira, Andreia Ferreira Nery, Leticia Rossetto da Silva Cavalcante, Ferry Hagen, Rosane Christine Hahn
Summary: Chromoblastomycosis is a chronic disease caused by melanized fungi that mainly affects individuals performing soil-related labor. The study analyzed epidemiological and clinical characteristics in Latin America and the Caribbean. Common clinical forms include verrucous and tumorous, with symptoms of itching and pain. Majority of cases were treated with itraconazole and surgery.
Review
Immunology
Luiz Felipe Domingues Passero, Italo Novais Cavallone, Walter Belda Jr
Summary: Chromoblastomycosis (CBM) is a neglected human disease caused by pigmented dematiaceous fungi, mainly affecting people working in agriculture in low-income countries. Despite some understanding of resistance and susceptibility in CBM, effective vaccines are still lacking. Limited progress has been made in treatment, with the use of immunomodulators showing promise.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Infectious Diseases
Minying Li, Huan Huang, Jun Liu, Xiaohui Zhang, Qian Li, Dongmei Li, Mingfen Luo, Xiaoyue Wang, Weiying Zeng, Jiufeng Sun, Hongfang Liu, Liyan Xi
Summary: The C-terminal thioesterase (TE) in F. monophora plays a crucial role in maintaining the fully function of pks1, impacting melanin synthesis and metabolism, and consequently affecting the growth and virulence of F. monophora.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Daiane Heidrich, Danielle Machado Pagani, Alessandra Koehler, Karine de Oliveira Alves, Maria Lucia Scroferneker
Summary: Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by melanized fungi, with melanin being a virulence factor influencing antifungal susceptibility. This study evaluated the effect of melanin inhibition on antifungal susceptibility of CBM agents and found that inhibition of melanin can increase the susceptibility of most agents to itraconazole and terbinafine, potentially opening up new therapeutic possibilities for refractory cases. Further studies are needed to confirm these results in vivo.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Daniel Wagner C. L. Santos, Conceicao de Maria Pedrozo e Silva de Azevedo, Vania Aparecida Vicente, Flavio Queiroz-Telles, Anderson Messias Rodrigues, G. Sybren de Hoog, David W. Denning, Arnaldo Lopes Colombo
Summary: Chromoblastomycosis (CBM) is a primary implantation mycosis caused by melanized fungi, mainly affecting populations living in poverty with significant morbidity. The global incidence remains unclear, emphasizing the need for more local epidemiological studies.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Chen Huang, Weiwei Deng, Yi Zhang, Kai Zhang, Yubo Ma, Yinggai Song, Zhe Wan, Xiaowen Wang, Ruoyu Li
Summary: This study reports a case of chromoblastomycosis caused by Phialophora expanda in a patient with a CARD9 mutation. Comparative transcriptome analysis revealed that P. expanda has stronger immunogenicity and is more prone to forming sclerotic bodies compared to P. americana. These findings suggest that fungal specificity, in addition to host defense, contributes to the clinical phenotype in CARD9 deficient patients with dematiaceous fungal infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Dermatology
S. H. Lee, S. B. Lee, J. H. Heo, H. S. Yoon, J. W. Byun, G. S. Choi, J. Shin
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Dermatology
Ji Hye Heo, Seung Dohn Yeom, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi
JOURNAL OF DERMATOLOGY
(2020)
Article
Dermatology
Jung Min Bae, Hyun Jeong Ju, Ro Woo Lee, Sang Ho Oh, Jeong Hyun Shin, Hee Young Kang, Ji Hun Park, Hee Jung Kim, Ki-Heon Jeong, Hee Jung Lee, SangHoon Lee, Dong Hyun Kim, Dong-Youn Lee, You Chan Kim, Gwang Seong Choi, Ki-Ho Kim, Chul Jong Park, Chong Won Choi
Article
Dermatology
Seon Bok Lee, Ji Hye Heo, Hee Seong Yoon, Si Hyub Lee, Ji Won Byun, Gwang Seong Choi, Jeonghyun Shin
JOURNAL OF CUTANEOUS PATHOLOGY
(2020)
Review
Dermatology
Jung Min Bae, Ki-Heon Jeong, Chong Won Choi, Ji Hun Park, Hee Jung Lee, Hee Jung Kim, Sang Hoon Lee, Sang Ho Oh, Jeonghyun Shin, Hee Young Kang, Weon Ju Lee, Hyun Jeong Ju, Dong Hyun Kim, Sung Eun Chang, Dong Youn Lee, You Chan Kim, Gwang Seong Choi, Ki-Ho Kim, Tae Heung Kim, Seung Chul Lee, Ai-Young Lee, Seung-Kyung Hann, Mu-Hyoung Lee, Chul Jong Park
Summary: Through a modified Delphi process involving 31 vitiligo experts, consensus was reached on 12 key questions related to the management of vitiligo, including treatments such as long-term phototherapy, corticosteroids, and surgical interventions. This consensus will complement current guidelines and assist in decision-making for physicians and patients in the treatment of vitiligo.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Letter
Dermatology
J. Oh, R. W. Lee, H. R. Lee, S. B. Lee, H. J. Ju, J. Park, H. R. Park, J. H. Park, S-K. Hann, A. Almurayshid, J. Shin, H. Y. Kang, J. M. Bae, S. H. Oh
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Hyun Jeong Ju, Ju Hee Han, Min-Soo Kim, Si-Hyung Lee, Jung-Won Shin, Mira Choi, Ki-Heon Jeong, Tae Young Han, Chong Won Choi, Hee Jung Lee, Sang Ho Oh, Sang Hoon Lee, Dong Hyun Kim, Jeonghyun Shin, Jong Hee Lee, Sang Seok Kim, Hee Young Kang, Sung Eun Chang, Jeong-Soo Kim, Dong-Youn Lee, Gwang Seong Choi, Dae Hun Suh, You Chan Kim, Chul Jong Park, Ki-Ho Kim, Ai-Young Lee, Kyoung Chan Park, Mu-Hyoung Lee, Jung Min Bae
Summary: This multicenter retrospective cohort study found that the long-term use of topical calcineurin inhibitors or phototherapy did not significantly increase the risk of developing lymphoma or skin cancer in vitiligo patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Hyun-Tae Shin, Si Hyub Lee, Hee Seong Yoon, Ji Hye Heo, Seon Bok Lee, Ji Won Byun, Jeonghyun Shin, Yun-Kyoung Cho, Eunkyung Chung, Myung-Shin Jeon, Sun U. Song, Gwang Seong Choi
Summary: The study demonstrated that clonal mesenchymal stem cell therapy showed long-term efficacy and safety in moderate to severe atopic dermatitis patients, with significant improvements in clinical symptoms. Despite increased IL-17 levels in some patients, overall observations showed positive outcomes.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Seon Bok Lee, Hyun-Tae Shin, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi
Summary: The study demonstrated that ASC-CM combined with 10,600 nm carbon dioxide fractional laser or microneedling may offer effective and safe treatment options for a refractory patch of alopecia areata.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jae-Won Song, Sunju Choi, Gayeong Kim, Hyang Bok Lee, P. Sankara Rao, Jeonghyun Shin, Eun Ki Kim, Dong-Gyu Cho
Summary: A novel melanoblast stimulator was isolated from Dimocarpus longan, which promotes the differentiation and migration of melanoblasts. This study discovered the melanogenic activity of 5-(hydroxymethyl)furfural (HMF) for the first time, providing a new potential drug foundation for treating vitiligo.
Letter
Dermatology
Hyun Jeong Ju, Ro Woo Lee, Sujin Park, Jung Min Bae, Sang Ho Oh, Jeonghyun Shin, Hee Young Kang
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Dermatology
Anna L. Chien, Daniel J. Kim, Nancy Cheng, Jeonghyun Shin, Sherry G. Leung, Amanda M. Nelson, Julie Zang, Hoseok Suh, Barbara Rainer, Luke Wallis, Ginette A. Okoye, Manisha Loss, Sewon Kang
Summary: In this study, although there was no significant difference in efficacy between this particular TTP formulation and tretinoin 0.02%, mechanistic studies highlighted MMP2 as a possible mediator of retinoid efficacy in photoaging.
Article
Dermatology
Hye Won Hwang, Seon Bok Lee, Jeonghyun Shin, Gwang Seong Choi, Ji Won Byun
Summary: PELVIS syndrome is a rare condition characterized by perineal hemangioma, external genitalia malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, and skin tag. A 2-month-old girl with perineal and genitalia hemangioma, imperforate anus, rectovaginal fistula, and perineal skin tag was diagnosed with PELVIS syndrome. Intrasacral meningocele was detected through spinal sonography, but no neurological deficits were found. The patient underwent surgical correction for the anorectal malformation and received oral propranolol for the cutaneous lesion, showing improvement without any complications.
ANNALS OF DERMATOLOGY
(2023)
Letter
Dermatology
Ji Hye Heo, Han Na Hyun, Seon Bok Lee, Hee Seong Yoon, Si Hyub Lee, Jeonghyun Shin, Gwang Seong Choi, Ji Won Byun
ANNALS OF DERMATOLOGY
(2021)
Letter
Dermatology
Ji Hye Heo, Han Na Hyun, Seon Bok Lee, Hee Seong Yoon, Si Hyub Lee, Seung Dohn Yeom, Jeonghyun Shin, Gwang Seong Choi, Ji Won Byun
ANNALS OF DERMATOLOGY
(2020)
