Article
Dentistry, Oral Surgery & Medicine
Chris J. Smith, Eric K. Parkinson, Jingjuin Yang, Jonathan Pratten, Edel A. O'Toole, Matthew P. Caley, Kristin M. Braun
Summary: This study explores the differential healing efficiencies and gene expression patterns of gingival and skin keratinocytes. Gingival keratinocytes demonstrated superior wound healing capabilities compared to skin, likely due to distinct migration patterns and gene expression differences. The development of organotypic models will further contribute to the analysis of oral wound response and potential therapeutic interventions in vitro.
JOURNAL OF DENTISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Hyo-Sung Kim, Hyun-Jeong Hwang, Han-Jun Kim, Yeji Choi, Daehyung Lee, Hong-Hee Jung, Sun Hee Do
Summary: Mammalian tissue extracellular matrix (ECM) has been used as a scaffold for tissue repair. This study investigated the properties and effects of decellularized ECM (dECM) from human lung fibroblasts on wound remodeling. The fibroblast-derived dECM (fdECM) maintained important components and growth factors, and when applied to skin wounds, facilitated wound contraction, angiogenesis, and qualitative skin remodeling. The therapeutic efficacy was also observed in a diabetic ulcer model. In vitro experiments revealed that fdECM helps tissue remodeling by regulating growth factors and signaling pathways.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Matheus Morais Saraiva, Matheus da Silva Campelo, Joao Francisco Camara Neto, Ana Beatriz Nogueira Lima, George de Almeida Silva, Andre Tavares de Freitas Figueredo Dias, Nagila Maria Pontes Silva Ricardo, David L. Kaplan, Maria Elenir Nobre Pinho Ribeiro
Summary: This article introduces the application of sodium alginate (SA) and polyvinyl alcohol (PVA) in wound dressing, and the improvement of the final healing materials by blending the two polymers. It also discusses the incorporation of different drugs into SA/PVA films to enhance wound healing. Additionally, the crosslinking of SA/PVA films with Ca2+ or other agents and their potential applications in the biomedical field are described.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Nur Izzah Md Fadilah, Manira Maarof, Antonella Motta, Yasuhiko Tabata, Mh Busra Fauzi
Summary: Current research focuses on the application of naturally derived biomaterials in treating wounds, particularly in wound care. Moist bioactive scaffolds have shown significant improvement in healing rates compared to traditional treatments. However, the failure or delay in wound healing adds financial and social burden to healthcare institutions, caregivers, patients, and their families. Therefore, there is a need for practical, safe, and cost-effective wound healing scaffolds from natural-based biomaterials to be introduced in clinical practice.
Article
Nanoscience & Nanotechnology
Li Mei, Dongjie Zhang, Huarong Shao, Yuanping Hao, Ting Zhang, Weiping Zheng, Yanjing Ji, Peixue Ling, Yun Lu, Qihui Zhou
Summary: Superbacteria-induced skin wound infections are significant health challenges. Probiotic therapy combined with biomimicking hydrogels shows great potential in treating infections and promoting wound repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Lanxiang Liu, Xiang Li, Gang Dong, Hong Zhang, Yun-Feng Tao, Rui He, Juan Xu, Jinju Ma, Baoshan Tang, Bei Zhou
Summary: Developing safe and effective wound dressings is a constant goal in biomaterials research. In this study, we have designed and developed a novel shellac-based dressing that exhibits high adhesion energy, pH sensitivity, and promotes wound healing. A new compound has also been synthesized to improve the antibacterial and blood coagulation properties of the dressing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Lanxiang Liu, Xiang Li, Gang Dong, Hong Zhang, Yun-Feng Tao, Rui He, Juan Xu, Jinju Ma, Baoshan Tang, Bei Zhou
Summary: In this study, a bioactive shellac-based wound dressing was designed and developed, which exhibited high adhesion energy and reversible binding. A novel compound was added to enhance antibacterial and blood coagulation properties. The dressing showed rapid hemostasis, wound sealing, and promoted wound healing. Molecular dynamics simulations demonstrated the beneficial effects of the shellac molecule on wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Fathe Singh, Vinu Vijayan, Sreelekshmi Sreekumar, Manikantan Syamala Kiran
Summary: The present study shows that Lawsone cross-linked collagen bio-scaffold can be used to manage aberrant wound healing, especially in post-surgical cancer margins. The combination of Lawsone and collagen enhances thermal and mechanical stability, structural integrity, and reduces susceptibility to proteolysis while maintaining biocompatibility. Lawsone exhibits anti-angiogenic, anti-migratory, and apoptotic effects specifically in cancer cells by increasing reactive oxygen species production. The biological properties of Lawsone cross-linked collagen bio-scaffold make it a promising anti-cancerous wound dressing 3-D bio-matrix biomaterial for healing of post-surgical wound margins.
Article
Chemistry, Applied
Haibin Yuan, Lin Chen, Feng F. Hong
Summary: This study investigated the wound healing effectiveness of bacterial nanocellulose (BNC) synthesized by different bacterial strains. It was found that the lower surfaces of BNC membranes showed better biocompatibility and the upper surfaces were denser. In vivo experiments demonstrated that the BNC membrane synthesized by the DHU-WX-1 strain had the highest wound repair efficacy.
CARBOHYDRATE POLYMERS
(2022)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qingtong Yu, Qilong Wang, Linzhi Zhang, Wenwen Deng, Xia Cao, Zhe Wang, Xuan Sun, Jiangnan Yu, Ximing Xu
Summary: With the increasing number of chronic wound patients worldwide, the financial burden and social pressure on patients are growing. Stem cells have emerged as promising seed cells for tissue engineering due to their various sources, differentiation ability, and proliferation rate. However, delivering them for skin injury treatment remains challenging, especially in the presence of bacteria that can affect wound healing. In this review, the use of 3D bioprinting for external delivery of stem cells and their antibacterial effects in improving wound healing is summarized.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Waqar Ahmad, Novin Pishevar, Leonard J. Cochrane, Andrew Reynolds, Joseph Kim, Ivan Korostenskij, Vincenza L. Geiser, Matthew D. Carson, Amy J. Warner, Peng Chen, Hai Yao, Alexander Alekseyenko, Jessica D. Hathaway-Schrader, Chad M. Novince
Summary: The aim of this study was to evaluate the impact of antibiotic prophylaxis on dental implant placement surgery-induced osteoimmune wound healing and osseointegration. The results showed that prophylactic antibiotics caused bacterial dysbiosis, suppressed helper T-cell immune response, reduced the number of osteoblasts and osteoclasts, and weakened the bone-implant interface. These findings suggest that antibiotic prophylaxis dysregulates the osteoimmune wound healing process induced by implant surgery.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Mingran Zhang, Jiaxue Liu, Tongtong Zhu, Hanxiang Le, Xukai Wang, Jinshan Guo, Guangyao Liu, Jianxun Ding
Summary: Bone adhesives are expected to have significant advantages in treating bone injuries compared to traditional internal fixation devices. Different research directions of bone adhesives, such as liquid scaffold and liquid plate, are summarized. Recent advances in mechanical strength, osseointegration, osteoconductivity, and osteoinductivity of bone adhesives are discussed.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Bogdan Neamtu, Andreea Barbu, Mihai Octavian Negrea, CristianStefan Berghea-Neamtu, Dragos Popescu, Marius Zahan, Vioara Miresan
Summary: Carrageenan is a significant biomaterial for wound healing, possessing properties such as water solubility, low cytotoxicity, antimicrobial, and antioxidant qualities. When combined with other materials, it can also aid in hemostasis and improve its overall performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Matheus Morais Saraiva, Matheus da Silva Campelo, Joao Francisco Camara Neto, Maria Leonia da Costa Gonzaga, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Renata Ferreira de Carvalho Leita, Maria Elenir Nobre Pinho Ribeiro
Summary: This study investigated the potential of polysaccharides from Agaricus blazei Murill mushroom (PAbs) as wound dressings. The results showed that PAbs had no significant impact on the viability of human neutrophils in a concentration range of 1-100 μg mL-1. Moreover, PAbs improved the mechanical properties, thickness, and water vapor permeation of the films, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Taesik Eom, Jisoo Jeon, Seunghyeon Lee, Kyungbae Woo, Jae Eun Heo, David C. Martin, Jeong Jae Wie, Bong Sup Shim
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2019)
Review
Materials Science, Multidisciplinary
Mary J. Donahue, Ana Sanchez-Sanchez, Sahika Inal, Jing Qu, Roisin M. Owens, David Mecerreyes, George G. Malliaras, David C. Martin
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2020)
Article
Nanoscience & Nanotechnology
Xiazhang Li, Zuo-Gang Huang, Haiguang Zhang, Yuying Zhang, Chunyan Zhang, Hui-Yin H. Li, David C. Martin, Chaoying Ni
Article
Biophysics
Seunghyeon Lee, Busra Ozlu, Taesik Eom, David C. Martin, Bong Sup Shim
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Polymer Science
Vivek Subramanian, David C. Martin
Summary: In this study, liquid-phase transmission electron microscopy (LPTEM) and correlative transmitted light optical microscopy were used to directly observe the electrode-solution interface during the electro-chemical deposition of PEDOT. The results showed distinct changes in properties such as edge roughness, size, circularity, and optical absorption during the formation of liquid-like (EDOT oligomer) droplets and solid-like (PEDOT polymer) films.
Article
Chemistry, Multidisciplinary
Vivek Subramanian, David C. Martin
Summary: Real-time observations using liquid-phase transmission electron microscopy revealed the nucleation and growth process of PEDOT nanofibrils. The nanofibrils exhibited anisotropic growth initially, with faster rates along their lengths compared to their widths and thicknesses.
Article
Materials Science, Multidisciplinary
Dan My Nguyen, Yuhang Wu, Abigail Nolin, Chun-Yuan Lo, Tianzheng Guo, Charles Dhong, David C. Martin, Laure Kayser
Summary: Electronically conductive hydrogels, with mechanical properties similar to biological tissues, are gaining popularity in bioelectronic interfaces. The integration of conducting polymers or nanoparticles into hydrogels is necessary to achieve conductivity, but it often affects the mechanical properties or leads to heterogeneous distribution. This study reports a two-step method for imparting conductivity to hydrogels without compromising their mechanical properties, resulting in homogeneous conductive hydrogels with good conductivity and similar elastic modulus to the original hydrogel.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Electrochemistry
Peter Sitarik, David C. Martin
Summary: This study investigates the electrochemical impedance behavior of Poly(3,4-ethylenedioxythiophene) (PEDOT) in salt solutions of different concentrations. The results demonstrate that changing the conductivity of the salt solution has a significant impact on the obtained impedance spectra.
Article
Materials Science, Multidisciplinary
Taesik Eom, Junghyun Lee, Seunghyeon Lee, Busra Ozlu, Sunwoo Kim, David C. Martin, Bong Sup Shim
Summary: The article presents an electrochemical synthesis method for highly conductive PDA composites and demonstrates their advantages in terms of electrochemical performance and structural modulation. This unique PDA composite can be used to develop edible/implantable/biodegradable electrodes, biosensors, and neuromorphic electrochemical devices for future bioelectronic applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Junghyun Lee, Shrirang Chhatre, Peter Sitarik, Yuhang Wu, Quintin Baugh, David C. Martin
Summary: This study investigates the electrochemical fabrication and characterization of OECTs using PEDOT with different counterion salts. The results show that the characteristic dimensions of PEDOT films can be controlled by total charge density, and the choice of counterion affects the smoothness of the films.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Peter Sitarik, Samadhan S. Nagane, Shrirang Chhatre, Yuhang Wu, Quintin Baugh, David C. Martin
Summary: This study describes the design, synthesis, and characterization of maleimide-functionalized 3,4-ethylenedioxythiophene (EDOT) monomers, and their corresponding polymers and copolymers. Novel varieties of functionalized monomers were developed and investigated, allowing for a wide variety of potentially useful variants of EDOT. The physical and chemical properties of the resulting polymer films were characterized, and their biocompatibility was examined.
MATERIALS ADVANCES
(2022)
Article
Polymer Science
Chun-Yuan Lo, Yuhang Wu, Elorm Awuyah, Dilara Meli, Dan My Nguyen, Ruiheng Wu, Bohan Xu, Joseph Strzalka, Jonathan Rivnay, David C. Martin, Laure Kayser
Summary: The commercially available polyelectrolyte complex PEDOT:PSS has been widely used in organic and hybrid electronics as a benchmark material. However, previous studies mainly focused on its electronic conductivity in dry environments and paid less attention to its ion transport, coupled ionic-electronic transport, and charge storage properties in aqueous environments. This study investigates the effects of the molecular weight and size distribution of PSS on the electronic properties and morphology of PEDOT:PSS in both dry and aqueous environments, as well as its performance in organic electrochemical transistors (OECTs). The results show that higher molecular weight and broad dispersity of PSS lead to OECTs with the highest transconductance and μC* values in PEDOT:PSS, despite having a lower volumetric capacitance. The microstructure of the films was found to play a key role in these differences. These findings emphasize the importance of considering molecular weight and size distribution in organic mixed ionic-electronic conductors for high-performance organic electronics in biological interfaces.
Article
Chemistry, Physical
Yuhang Wu, Samadhan S. Nagane, Peter Sitarik, Shrirang Chhatre, Junghyun Lee, David C. Martin
Summary: In this study, the capacitive behavior of electrodeposited PEDOT-maleimide and PEDOT was compared. The results showed that PEDOT-maleimide exhibited higher areal specific capacitance, better cyclic stability, and improved mechanical properties compared to PEDOT. The surface roughness of PEDOT-maleimide also varied at different length scales, and its conductivity was lower than that of PEDOT. However, both materials showed similar impedance performance, indicating effective charge transport. These findings suggest that PEDOT-maleimide is a promising alternative to PEDOT for charge storage applications.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Materials Science, Multidisciplinary
Samadhan Nagane, Peter Sitarik, Yuhang Wu, Quintin Baugh, Shrirang Chhatre, Junghyun Lee, David C. Martin
Article
Green & Sustainable Science & Technology
Seunghyeon Lee, Hong Seop Hwang, Whirang Cho, Daseul Jang, Taesik Eom, David C. Martin, Jeong Jae Wie, Bong Sup Shim
ADVANCED SUSTAINABLE SYSTEMS
(2020)
