4.4 Article

SEPARATION OF TIME-SCALES AND MODEL REDUCTION FOR STOCHASTIC REACTION NETWORKS

期刊

ANNALS OF APPLIED PROBABILITY
卷 23, 期 2, 页码 529-583

出版社

INST MATHEMATICAL STATISTICS-IMS
DOI: 10.1214/12-AAP841

关键词

Reaction networks; chemical reactions; cellular processes; multiple time scales; Markov chains; averaging; scaling limits; quasi-steady state assumption

资金

  1. NSF [DMS 05-53687, 08-05793]
  2. Division Of Mathematical Sciences
  3. Direct For Mathematical & Physical Scien [1106424] Funding Source: National Science Foundation

向作者/读者索取更多资源

A stochastic model for a chemical reaction network is embedded in a one-parameter family of models with species numbers and rate constants scaled by powers of the parameter. A systematic approach is developed for determining appropriate choices of the exponents that can be applied to large complex networks. When the scaling implies subnetworks have different time-scales, the subnetworks can be approximated separately, providing insight into the behavior of the full network through the analysis of these lower-dimensional approximations.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据