Article
Allergy
Olivier Drouin, Anna Smyrnova, Natalie Betinjane, Francine M. Ducharme
Summary: The study found that once-daily dosing of inhaled corticosteroids is associated with better medication adherence among children with asthma. Children in the once-daily dosing group had higher adherence and a greater likelihood of achieving adherence greater than or equal to 75%.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Clinical Neurology
Sung Hyun Kim, Hyemi Lee, Dong Wook Kim
Summary: The study investigated the seizure improvement in patients with drug-resistant epilepsy related to AED non-adherence after switching to once-daily dosing regimens. Results showed that successful switch was associated with patients without MRI abnormality and those switched to extended-release formulations or different AEDs with longer half-lives.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Multidisciplinary Sciences
Joy Lee, Jacqueline Huvanandana, Juliet M. Foster, Helen K. Reddel, Michael J. Abramson, Cindy Thamrin, Mark Hew
Summary: The study found that entropy analysis can provide insights into patient adherence behavior, with significant associations found between this analysis and asthma patients' quality of life, symptom control, and future asthma attacks.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Heather De Keyser, Vy Vuong, Leanne Kaye, William C. Anderson, Stanley Szefler, David A. Stempel
Summary: This study assessed adherence differences in patients with asthma and COPD using once- or twice-daily doses of controller inhalers. The results showed that patients using once-daily doses had higher adherence compared to those using twice-daily doses. This finding was consistent across different age groups, except for adolescents with asthma. This study is important for understanding the impact of medication adherence on disease management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Laurent Godinas, Fabienne Dobbels, Leni Hulst, Ive Verbeeck, Ines De Coninck, Pieter Berrevoets, Veronique Schaevers, Jonas Yserbyt, Lieven J. Dupont, Stijn E. Verleden, Bart M. Vanaudenaerde, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Arne Neyrinck, Geert M. Verleden, Robin Vos
Summary: Conversion from twice daily to once daily tacrolimus in lung transplant patients requires close monitoring of tacrolimus trough levels. Post-conversion, once daily tacrolimus is safe with respect to renal function, metabolic parameters and allograft function, and improves patient adherence.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Endocrinology & Metabolism
Ildiko Lingvay, John B. Buse, Edward Franek, Melissa V. Hansen, Mette M. Koefoed, Chantal Mathieu, Jeremy Pettus, Karolina Stachlewska, Julio Rosenstock
Summary: The study investigated the efficacy and safety of a novel once-weekly basal insulin analog, insulin icodec, using different titration algorithms. The results showed that icodec was efficacious and well tolerated across all three titration algorithms, with titration algorithm B demonstrating the best balance between glycemic control and risk of hypoglycemia.
Article
Medicine, Research & Experimental
Peter Daley-Yates, Dave Singh, Juan M. Igea, Luigi Macchia, Manish Verma, Norbert Berend, Maximilian Plank
Summary: This article reviews the efficacy and systemic activity profiles of fluticasone furoate (FF)-containing and budesonide (BUD)-containing asthma therapies in clinical trials and real-world studies. The results indicate that regular daily FF or FF/vilanterol (VI) dosing provides more prolonged bronchoprotection and fewer systemic effects compared to daily BUD, daily BUD/formoterol (FOR), or BUD/FOR maintenance and reliever therapy (MART) dosing, especially in low adherence scenarios.
ADVANCES IN THERAPY
(2023)
Article
Multidisciplinary Sciences
Vivek Sood, Kajal Kamboj, Prateek Bhatia, Vishal Sharma, Monica Kundu, Arpita Ghosh, Sanjay Kumar Singh, Thakur Sen, Prabhjot Kaur, Raja Ramachandran, Manish Rathi, Harbir Singh Kohli, Krishan Lal Gupta, Samir Malhotra, Ashok Kumar Yadav, Vivek Kumar, Vivekanand Jha
Summary: This study investigated the effects of two dosing regimens of oral iron on iron status and hematological parameters in CKD patients. The results showed no significant difference in TSAT changes between the groups, but the OD group had a smaller increase in serum ferritin and an increase in MCHC compared to the BD group.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Harpreet S. Bajaj, Richard M. Bergenstal, Andreas Christoffersen, Melanie J. Davies, Amoolya Gowda, Joakim Isendahl, Ildiko Lingvay, Peter A. Senior, Robert J. Silver, Roberto Trevisan, Julio Rosenstock
Summary: The study demonstrated that switching from daily basal insulin to once-weekly icodec was well tolerated and provided effective glycemic control. The use of a loading dose when switching to once-weekly icodec significantly increased the percent time in range during weeks 15 and 16 compared to once-daily IGlar U100, without increasing the risk of hypoglycemia.
Article
Pediatrics
Megha Goyal, Vishal Guglani, Pankaj Kumar, Shivani Randev
Summary: A study compared the effects of once-daily versus twice-daily administration of inhaled budesonide on morning peak expiratory flow rate and clinical asthma control in children. The results showed that once-daily administration was noninferior to twice-daily administration in terms of efficacy.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Allergy
Britt Overgaard Hedegaard, Kjell Erik Julius Hakansson, Frodi Fridason Jensen, Charlotte Suppli Ulrik, Ulla Moller Weinreich
Summary: This study aimed to evaluate the reliability of using the Foster score to assess adherence to inhaled corticosteroids in adults with asthma. The study found that self-reported adherence scores were higher than objective measures of adherence, indicating some discrepancy between the Foster score and medication possession ratio.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Multidisciplinary Sciences
Hui-Jeong Hwang, Il Suk Sohn, Eun-Sun Jin, Yoon-Jong Bae
Summary: This study found that twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) may lead to reduced drug adherence and worsen clinical outcomes in patients with atrial fibrillation (AF). The adherence to each NOAC and the subsequent clinical outcomes were compared between different dosing regimens. The results showed that adherence was high and similar between once- and twice-daily dosing regimens, but patients with low adherence had poorer clinical outcomes regardless of the dosing frequency.
Review
Hematology
S. Mainbourg, M. Cucherat, S. Provencher, L. Bertoletti, P. Nony, F. Gueyffier, P. Mismetti, C. Grange, I. Durieu, R. Kilo, S. Laporte, G. Grenet, J. -C. Lega
Summary: The study indicates that there is no significant difference in terms of efficacy and safety between the once daily (QD) and twice daily (BID) dosing regimens of direct oral anticoagulants in major orthopedic surgery, non-valvular atrial fibrillation, venous thromboembolism, and acute coronary syndrome. No heterogeneity was found in the results for major thrombotic events and major bleeding.
THROMBOSIS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Max M. Maurer, Marius Ibach, Julius Plewe, Axel Winter, Paul Ritschl, Brigitta Globke, Robert oellinger, Georg Lurje, Wenzel Schoening, Johann Pratschke, Dennis Eurich
Summary: The objective of this study was to investigate the adherence, efficacy, and safety after converting stable liver transplant patients from IR-Tac to LCP-Tac. The results showed that LCP-Tac improved adherence and was safe for use in liver transplant patients.