Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Letter
Allergy
Pinja Ilmarinen, Iida Vahatalo, Leena E. Tuomisto, Onni Niemela, Hannu Kankaanranta
Summary: The long-term adherence to inhaled corticosteroids was 75% or higher in phenotypes with the worst outcome, but did not vary significantly among clusters. Poor outcomes in the most severe phenotypes were not associated with poor adherence to inhaled corticosteroid medication.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Public, Environmental & Occupational Health
Yousif S. Alakeel, Ebtihal F. Alharbi, Haifa A. Alhaidal, Aisha M. Jumaa, Latifah K. Albaiahy, Noura S. Alsagami, Shatha A. Alshahrani
Summary: This study investigated the relationship between the use of inhaled corticosteroids (ICS) by asthmatic patients and the severity of COVID-19. The findings showed that ICS therapy did not alter the severity or mortality of COVID-19 in asthmatic patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Pediatrics
Rikke Moller, Bibi Uhre Nielsen, Daniel Faurholt-Jepsen, Terese Lea Katzenstein, Marianne Skov, Lue Katrine Drasbaek Philipsen, Tacjana Pressler, Helle Krogh Johansen, Tavs Qvist
Summary: This study investigated the use of inhaled antibiotics and adherence patterns in cystic fibrosis patients. The findings showed that changing antibiotics and using off-label antibiotics were common, and side effects were not a major cause of nonadherence.
PEDIATRIC PULMONOLOGY
(2022)
Article
Multidisciplinary Sciences
Joy Lee, Jacqueline Huvanandana, Juliet M. Foster, Helen K. Reddel, Michael J. Abramson, Cindy Thamrin, Mark Hew
Summary: The study found that entropy analysis can provide insights into patient adherence behavior, with significant associations found between this analysis and asthma patients' quality of life, symptom control, and future asthma attacks.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Rosario Lineros, Lourdes Fernandez-Delgado, Antonio Vega-Rioja, Pedro Chacon, Bouchra Doukkali, Javier Monteseirin, David Ribas-Perez
Summary: Inhaled corticosteroids (ICSs) are commonly used in COPD with LABAs to reduce exacerbations and improve lung function and quality of life. However, there is an uncertain risk of pneumonia associated with ICS use in COPD. The causes of pneumonia in COPD patients are not always considered in studies on ICS risks. It is important to clarify the impact of ICSs on pneumonia incidence and their role in COPD treatment.
Article
Pediatrics
Louise Mandrup Bach, Sune Rubak, Adam Holm-Weber, Julie Prahl, Mette Hermansen, Kirsten Skamstrup Hansen, Bo Chawes
Summary: This study aimed to determine the risk factors for non-adherence to asthma treatment in preschool children. The study found that 75% of children under 6 years old diagnosed with asthma were not adherent to their medication. Increasing adherence was associated with co-existing allergies and experiencing loss of control events, while lower adherence was associated with atopic predisposition.
Review
Immunology
Wenli Shang, Guizuo Wang, Yan Wang, Dong Han
Summary: This study aimed to evaluate the safety of long-term use of ICS in patients with asthma through a systematic review and meta-analysis. The results showed that, apart from mild local adverse events, the long-term use of ICS was safe for patients with asthma.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Raza Ul Mohsin, Christian Kjer Heerfordt, Josefin Eklof, Pradeesh Sivapalan, Mohamad Isam Saeed, Truls Sylvan Ingebrigtsen, Susanne Dam Nielsen, Zitta Barrella Harboe, Kasper Karmark Iversen, Jette Bangsborg, Jens Otto Jarlov, Jonas Bredtoft Boel, Christian Ostergaard Andersen, Henrik Pierre Calum, Ram B. Dessau, Jens-Ulrik Staehr Jensen
Summary: This study found that the use of inhaled corticosteroids (ICS) in outpatients with chronic obstructive pulmonary disease (COPD) is associated with an increased risk of acquiring Haemophilus influenzae infection, and this risk is dose-dependent, indicating that caution should be exercised when using high-dose ICS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Christina J. Pearce, Amy H. Y. Chan, Tracy Jackson, Louise Fleming, Holly Foot, Andy Bush, Rob Horne
Summary: Adherence interventions in children with asthma vary in effectiveness. Effective intervention studies are more likely to be of high quality, tailored to individual perceptual and practical adherence barriers, and utilize multiple behavior change techniques.
PEDIATRIC PULMONOLOGY
(2022)
Article
Respiratory System
Alison Moore, Andrew Preece, Raj Sharma, Liam G. Heaney, Richard W. Costello, Robert A. Wise, Andrea Ludwig-Sengpiel, Giselle Mosnaim, Jamie Rees, Ryan Tomlinson, Ruth Tal-Singer, David A. Stempel, Neil Barnes
Summary: This study evaluated the effect of a connected inhaler system on adherence to asthma maintenance therapy, finding that feedback data and increasing patients' use of maintenance medication can improve adherence and reduce the use of rescue medication in patients with uncontrolled asthma.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Respiratory System
Hetal Dhruve, David J. Jackson
Summary: Infrequent use of inhaled corticosteroids and over-reliance of short-acting beta-agonists are recognized as key contributors to increased morbidity and mortality in asthma. Electronic monitoring devices have the potential to improve asthma care by accurately tracking medication use and providing feedback to patients. This is a significant step forward in asthma management.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Health Care Sciences & Services
Ahmad H. Alghadir, Amir Iqbal, Zaheen A. Iqbal
Summary: This study investigates the perception and attitudes of patients in the Riyadh region of Saudi Arabia about the security of herbal medicines (HMs), and finds that the majority of patients use HMs without professional supervision, putting them at risk of harmful side effects and drug interactions.
Article
Oncology
Mohamed Aboufaras, Karima Selmaoui, Rajae Najib, Asmaa Lakhdissi, Nadia Ouzennou
Summary: Moroccan studies have revealed a high prevalence of traditional herbal medicine use, with female gender, positive attitudes and beliefs towards T&CM, and influence from relatives being key predictors. Users of traditional herbal medicine in Morocco are often women who experience pain and psychosocial impact from cancer and hold positive beliefs about T&CM.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)