Article
Immunology
Chanu Rhee, Kathleen Chiotos, Sara E. Cosgrove, Emily L. Heil, Sameer S. Kadri, Andre C. Kalil, David N. Gilbert, Henry Masur, Edward J. Septimus, Daniel A. Sweeney, Jeffrey R. Strich, Dean L. Winslow, Michael Klompas
Summary: The Infectious Diseases Society of America (IDSA) is concerned about the potential for antibiotic overuse due to the SEP-1 measure and has outlined recommendations to limit its application to patients with septic shock. The IDSA believes that managing possible sepsis without shock should be guided by more appropriate guidelines that allow for individualized patient care.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Marcela Hortova-Kohoutkova, Monika Skotakova, Isaac G. Onyango, Miriam Slezakova, Roman Panovsky, Lukas Opatril, Peter Slanina, Marco De Zuani, Ondrej Mrkva, Ivana Andrejcinova, Petra Laznickova, Martina Dvoncova, Alexandra Mytnikova, Vaughn Ostland, Michal Sitina, Gorazd B. Stokin, Vladimir Sramek, Marcela Vlkova, Martin Helan, Jan Fric
Summary: This study investigated the dynamics of iron regulation in different clinical settings and determined the suitability of hepcidin and/or ferritin levels as biomarkers of inflammatory disease severity. The results showed that hepcidin levels reflect overall immune cell activation driven by intrinsic stimuli, while ferritin levels are more strongly influenced by pathogen-induced inflammation. Furthermore, the hepcidin-to-ferritin ratio has the ability to predict mortality in septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Sophia Bonnin, John J. Radosevich, Yong Gu Lee, Jeremy P. Feldman, Jeffrey F. Barletta
Summary: This multi-center retrospective study compared the shock reversal outcomes between low dose and high dose hydrocortisone regimens in patients with septic shock. High dose steroids were found to be associated with shock reversal, but this was not confirmed in propensity score matched analysis. High dose steroids were also associated with reduced need for additional vasopressor therapy and lower shock recurrence rates.
JOURNAL OF CRITICAL CARE
(2021)
Article
Medicine, Research & Experimental
Xue-song Zhao, Zhao-li Meng, Tuo Zhang, Hong-na Yang, Ji-cheng Zhang, Wei Fang, Chun-ting Wang, Man Chen
Summary: The combined measurement of procalcitonin (PCT), thromboelastography (TEG), and platelet (PLT) count can predict the development of septic shock in high-risk patients. Compared to the sepsis group, the septic shock group had lower PLT count and TEG measurements, longer prothrombin time (DT), longer activated partial thromboplastin time (APTT), and higher PCT levels. Multivariate logistic regression analysis revealed that PCT, TEG, and PLT count were associated with the development of septic shock. Area under the curve analysis showed that the combined measurement of PCT, TEG, and PLT count was more accurate in predicting the development of septic shock compared to individual measurements.
CURRENT MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Isao Nagata, Toshikazu Abe, Hiroshi Ogura, Shigeki Kushimoto, Seitaro Fujishima, Satoshi Gando
Summary: The study aimed to determine the association between ICU model and in-hospital mortality of patients with severe sepsis and septic shock. Patients in the closed ICU group had higher severity scores, but there was no significant difference in in-hospital mortality compared to the open ICU group.
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.
Article
Engineering, Biomedical
Fudan Zheng, Luhao Wang, Yuxian Pang, Zhiguang Chen, Yutong Lu, Yuedong Yang, Jianfeng Wu
Summary: Septic shock has become the leading cause of morbidity and mortality in the ICU. However, currently there is no model to predict the mortality of septic shock patients. We aim to develop such a model.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Medicine, General & Internal
Veronika Tomaskova, Alexandra Mytnikova, Marcela Hortova Kohoutkova, Ondrej Mrkva, Monika Skotakova, Michal Sitina, Katerina Helanova, Jan Fric, Jiri Parenica, Vladimir Sramek, Martin Helan
Summary: This study examined the ability of sEng to predict mortality and its correlation with other clinical characteristics in septic shock patients and severe COVID-19 patients. The results showed that sEng was not predictive of mortality or correlated with organ dysfunction markers in COVID-19 patients. However, in septic shock patients, sEng levels were significantly higher in patients with early mortality and correlated with signs of circulatory failure.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Pedro Martinez-Paz, Marta Aragon-Camino, Esther Gomez-Sanchez, Mario Lorenzo-Lopez, Estefania Gomez-Pesquera, Alejandra Fadrique-Fuentes, Pilar Liu, Alvaro Tamayo-Velasco, Christian Ortega-Loubon, Marta Martin-Fernandez, Hugo Gonzalo-Benito, Emilio Garcia-Moran, Maria Heredia-Rodriguez, Eduardo Tamayo
Summary: The study aims to distinguish between septic shock and non-septic shock in postoperative patients through gene expression signature, providing personalized treatment and avoiding unnecessary antibiotic use and increased healthcare costs.
JOURNAL OF INFECTION
(2021)
Article
Pathology
Rob G. H. Driessen, Bartholomeus G. H. Latten, Dennis C. J. J. Bergmans, Riquette P. M. G. Hulsewe, Johanna W. M. Holtkamp, Iwan C. C. van der Horst, Bela Kubat, Ronny M. Schnabel
Summary: Autopsies in early deceased septic patients can reveal missed clinical diagnoses, with myocardial infarction and pneumonia being the most common missed diagnoses. This highlights the importance of autopsies as a diagnostic tool in identifying definite causes of death in sepsis patients.
Review
Critical Care Medicine
Jing Yue, Ronghao Zheng, Huiping Wei, Jie Li, Jiannan Wu, Ping Wang, Hui Zhao
Summary: The study found that in pediatric patients with septic or severe infection shock, the no bolus group showed significantly lower mortality rates at 48 hours, especially in cases of malaria. Similar results were observed with colloids and crystalloids solution treatment in malaria shock patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Swarnima Pandey, Mohd Adnan Siddiqui, Afzal Azim, Neeraj Sinha
Summary: This study identified metabolic signatures associated with treatment responsiveness, which can aid in the development of personalized treatment protocols and targeted therapy for ICU patients.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Emergency Medicine
Joseph D. Lykins, Hani I. Kuttab, Erron M. Rourke, Michelle D. Hughes, Eric P. Keast, Jason A. Kopec, Brooke L. Ward, Natasha N. Pettit, Michael A. Ward
Summary: Factors associated with delayed administration of the second dose of antibiotics include ED boarding, antibiotics requiring more frequent dosing, receiving 30 mL/kg of fluids within three hours, and renal failure. Delays in second-dose administration were not found to be associated with increased mortality or other outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pediatrics
Emile Simard, Christophe Morin, David Coquerel, Frederic Chagnon, Charlene Nadeau, Nathalie Samson, Jean-Paul Praud, Olivier Lesur, Etienne Fortin-Pellerin
Summary: This study aimed to assess the hemodynamic impacts of Apelin-13 in a neonatal lamb septic shock model. The results showed that Apelin-13 increased mean arterial pressure but also increased systemic vascular resistances.
PEDIATRIC RESEARCH
(2023)
Review
Cell Biology
Federico Carbone, Luca Liberale, Alberto Preda, Thomas Hellmut Schindler, Fabrizio Montecucco
Summary: The onset of cardiomyopathy in sepsis is a common feature that affects its pathophysiology and clinical care. However, there is a lack of consensus in the definition of sepsis-induced cardiomyopathy, and the wide range of ultrasonographic findings may not fully reflect the understanding of the condition. This review explores the current state of research on sepsis-related cardiomyopathy, highlighting the shortcomings in its definition and discussing the dynamic changes in cardiac performance in response to different hemodynamic clusters. The review also addresses the molecular mechanisms leading to myocardial dysfunction and their similarities to myocardial hibernation.
Article
Materials Science, Textiles
F. X. Capdevila, Enric Carrera-Gallissa, Mercedes Escusa, Micaela Rotela
JOURNAL OF THE TEXTILE INSTITUTE
(2020)
Article
Surgery
Michel Prudhomme, Eric Rullier, Zaher Lakkis, Eddy Cotte, Yves Panis, Bernard Meunier, Philippe Rouanet, Jean-Jacques Tuech, Mehrdad Jafari, Guillaume Portier, Anne Dubois, Igor Sielezneff, Yann Parc, Jean-Luc Faucheron, Guillaume Meurette, Bernard Lelong, Guillaume Piessen, Mehdi Karoui, Pascale Fabbro-Peray, Christophe Demattei, Martin M. Bertrand
Summary: The study did not find evidence that systematic mesh implantation during primary colostomy creation was effective in preventing parastomal hernia. The positioning of the mesh in a retro-muscular position with a central incision for colon passage was not recommended as a method to prevent parastomal hernia. Optimization of mesh location and reinforcement material is recommended for future research.
Review
Surgery
Michel Prudhomme, Pascale Fabbro-Peray, Eric Rullier, Bob Occean, Martin M. Bertrand
Summary: Recent studies have shown that there is no significant difference in the rate of incisional hernia formation between the mesh and non-mesh groups at both 1 and 2-year follow ups, therefore the use of a mesh is not recommended.
Article
Oncology
Thiebaud Picart, David Meyronet, Johan Pallud, Chloe Dumot, Philippe Metellus, Sonia Zouaoui, Moncef Berhouma, Francois Ducray, Luc Bauchet, Jacques Guyotat
Summary: The study analyzed data from 118 patients with cerebellar glioblastoma and concluded that in selected patients, maximal resection of the tumor is associated with improved oncological and functional outcomes compared to less invasive procedures.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Herve Ghesquieres, Cedric Rossi, Fanny Cherblanc, Sandra Le Guyader-Peyrou, Fontanet Bijou, Pierre Sujobert, Pascale Fabbro-Peray, Adeline Bernier, Aurelien Belot, Loic Chartier, Luc-Matthieu Fornecker, Isabelle Baldi, Krimo Bouabdallah, Camille Laurent, Lucie Oberic, Nadine Morineau, Steven Le Gouill, Franck Morschhauser, Corinne Haioun, Gandhi Damaj, Stephanie Guidez, Gaelle Laboure, Olivier Fitoussi, Laure Lebras, Remy Gressin, Gilles Salles, Loic Ysebaert, Alain Monnereau
Summary: The lymphoma incidence rates in France have been increasing since the early 80s, but the growth has slowed since 2010 and varies across subtypes. The REALYSA study is a real-life multicentric cohort aimed at studying prognostic factors in lymphoma patients.
Article
Oncology
Isabelle Baldi, Lucie De Graaf, Ghislaine Bouvier, Anne Gruber, Hugues Loiseau, Matthieu Meryet-Figuiere, Sarah Rousseau, Pascale Fabbro-Peray, Pierre Lebailly
Summary: This study found that occupational pesticide exposure, both in agriculture and outside, may increase the risk of central nervous system tumors, especially when exposed for more than 10 years in agriculture or in open field agriculture.
CANCER CAUSES & CONTROL
(2021)
Article
Immunology
Mehwish Younas, Christina Psomas, Christelle Reynes, Renaud Cezar, Lucy Kundura, Pierre Portales, Corinne Merle, Nadine Atoui, Celine Fernandez, Vincent Le Moing, Claudine Barbuat, Albert Sotto, Robert Sabatier, Audrey Winter, Pascale Fabbro, Thierry Vincent, Jacques Reynes, Pierre Corbeau
Summary: This study found that some HIV-1-infected patients under efficient treatment display low-level viremia and unique features of immune activation distinct from microbial translocation. Patients with Profile E exhibited high levels of CD4+ T cell, monocyte, and endothelium activation, while other patients had different profiles of immune activation. These findings suggest a potential causal link between low-level viremia and atherosclerosis in virologic responders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Anesthesiology
Benjamin Mounet, Olivier Choquet, Fabien Swisser, Philippe Biboulet, Nathalie Bernard, Sophie Bringuier, Xavier Capdevila
Summary: The study compared the haemodynamic stability of general anaesthesia (GA), continuous spinal anaesthesia (CSA), and multiple nerve blocks (MNB) in elderly patients undergoing hip fracture surgery. The results showed that CSA and MNB provided better haemodynamic stability than GA, but mortality rates did not differ significantly between the groups regardless of the anaesthesia technique used.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2021)
Article
Medicine, General & Internal
Chris Serrand, Thibault Mura, Pascale Fabbro-Peray, Gilles Seni, Eve Mousty, Thierry Boudemaghe, Jean-Christophe Gris
Summary: This study found that a history of preeclampsia/eclampsia during first pregnancy was associated with an increase in the incidence of myelodysplastic or myeloproliferative diseases and kidney cancer, while it was associated with a decrease in the incidence of cervical and breast cancers.
Article
Medicine, Research & Experimental
Laetitia Crouzet, Anne Gramond, Carey Suehs, Pascale Fabbro-Peray, Mocrane Abbar, Jorge Lopez-Castroman
Summary: This study aims to compare the effectiveness of a new therapeutic program based on third-generation cognitive behavioral therapy (Hyper-mCBT) with the Barkley program in improving ADHD symptoms in children and their parents. The study will randomly assign 248 children diagnosed with ADHD to either the Hyper-mCBT program or the Barkley program, and evaluate the outcomes. The results will contribute to the development of innovative psychotherapy programs for ADHD.
Article
Critical Care Medicine
Sonia Tazerout, Orianne Martinez, Benjamin Monsonis, Ingrid Millet, Patrice Taourel, Xavier Capdevila, Jonathan Charbit
Summary: This study aimed to assess the association between acute post-traumatic atrophy (APTMA) determined on psoas computed tomography (CT) scan and the duration of mechanical ventilation and outcomes in severe trauma patients. The results showed that the severity of APTMA was significantly associated with longer durations of mechanical ventilation, catecholamine use, ICU and hospital stays, as well as complications.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Anesthesiology
Severin Ramin, Matteo Arcelli, Karim Bouchdoug, Thomas Laumon, Camille Duflos, Audrey De Jong, Samir Jaber, Xavier Capdevila, Jonathan Charbit
Summary: In chest trauma patients, high APrs-ARDS was not significantly associated with an increase in mechanical ventilation duration or mortality risk.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Review
Anesthesiology
Stefano Calciolari, Laura Guadalupe Gonzalez-Ortiz, Francesco Mongelli, Laura Cantini, Xavier Capdevila, Davide La Regina, Andrea Saporito
Summary: The study aims to determine the incidence of adverse events associated with regional anesthesia, particularly during peripheral nerve blocks, and evaluate the associated healthcare and social costs. A systematic search was conducted and data from selected studies were analyzed. Despite the relatively low incidence of adverse events following peripheral nerve blocks, the associated costs should be carefully considered.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
Mathieu Capdevila, Audrey De Jong, Yassir Aarab, Aurelie Vonarb, Julie Carr, Nicolas Molinari, Xavier Capdevila, Laurent Brochard, Samir Jaber
Summary: This study aims to evaluate the effectiveness of different spontaneous breathing trials for assessing the ability of patients to sustain respiratory effort after extubation. It is a multicenter randomized physiological study that will categorize patients into five groups based on their illness and analyze the inspiratory muscle effort, changes in physiological variables, and respiratory parameters. The study has been approved by an ethics committee and informed consent is required.
Letter
Surgery
Michel Prudhomme, Pascale Fabbro-Peray, Bob V. Occean, Martin M. Bertrand