Article
Pharmacology & Pharmacy
Regina Scherliess, Simon Bock, Nicholas Bungert, Anna Neustock, Lena Valentin
Summary: Dry powder inhalation is an effective method for treating respiratory diseases, but faces challenges in formulation development. This review provides an overview of particle engineering as a formulation technique and optimization approach, and discusses future possibilities for carrier engineering.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Debora Santonocito, Carmelo Puglia
Summary: Nowadays, lungs are commonly affected by diseases due to various factors. Conventional pharmacotherapy has limitations in terms of selectivity and side effects. Pulmonary drug delivery using nanocarriers is a promising strategy to overcome these issues. This review aims to analyze the use of nanocarriers in treating lung diseases.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Ho Wan Chan, Hok Wai Lee, Stephanie Chow, David Chi Leung Lam, Shing Fung Chow
Summary: This study developed a continuous process for fabricating inhalable nanoagglomerate dry powder formulations of remdesivir (RDV). The optimized formulation showed good redispersibility and aerosol performance, and the RDV nanoparticles displayed enhanced cell uptake and low cytotoxicity in vitro. Moreover, the continuous manufacturing process showed no significant differences in the quality attributes compared to the standalone batch mode.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Rongchao Mei, Yunqing Wang, Xizhen Zhao, Qi Kang, Dazhong Shen, Lingxin Chen
Summary: Understanding the behavior of photothermal nanomedicines (PTNMs) in vivo is crucial for drug development and evaluation, but remains challenging. A near-infrared light-responsive surface-enhanced Raman scattering strategy can reveal key parameters such as the depth of PTNMs under biological tissue and the drug release ratio in vivo. This study provides a new avenue for studying drug release of PTNMs and reporting depth accurately, promoting the application of PTNMs in vivo.
ANALYTICAL CHEMISTRY
(2021)
Review
Biology
Andreea Crintea, Alina Gabriela Dutu, Gabriel Samasca, Ioan Alexandru Florian, Iulia Lupan, Alexandra Marioara Craciun
Summary: Cancer is considered the principal cause of death worldwide, with lung cancer being a heterogeneous condition influenced significantly by genome modifications. Traditional chemotherapy and radiotherapy have many side effects, prompting the continuous development of new strategies for cancer management. Nanomedicine plays a crucial role in cancer detection and treatment, although the cytotoxicity of nanosystems remains a debated issue.
Article
Chemistry, Multidisciplinary
Veronica Duran, Elena Grabski, Constantin Hozsa, Jennifer Becker, Hanzey Yasar, Joao T. Monteiro, Bibiana Costa, Nicole Koller, Yvonne Lueder, Bettina Wiegmann, Gudrun Brandes, Volkhard Kaever, Claus-Michael Lehr, Bernd Lepenies, Robert Tampe, Reinhold Foerster, Berislav Bosnjak, Marcus Furch, Theresa Graalmann, Ulrich Kalinke
Summary: The antibiotic treatment of tuberculosis is complex and lengthy, and can lead to poor patient compliance and the selection of multi-drug resistant bacteria. Encapsulating levofloxacin in lipid nanocarriers functionalized with fucosyl residues has shown to target MMR-positive cells more efficiently, improving the delivery and efficacy of the antibiotic in clearing the pathogen. Carbohydrate-functionalized nanocarriers present a promising tool for enhancing TB treatment by targeted antibiotic delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Pranav Ponkshe, Sheng Feng, Chalet Tan
Summary: Inhalation delivery of liposomal drugs offers advantages for treating pulmonary diseases, with several inhalable liposomes currently in clinical trials for various indications in the lungs. This review discusses the general principles of pulmonary delivery and the clinical development of inhalable liposomal drugs.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Sergio R. S. Veloso, Ecem Tiryaki, Carlos Spuch, Loic Hilliou, C. O. Amorim, V. S. Amaral, Paulo J. G. Coutinho, Paula M. T. Ferreira, Veronica Salgueirino, Miguel A. Correa-Duarte, Elisabete M. S. Castanheira
Summary: This study presents a novel design approach to modulate drug release through the co-assembly of nanoparticles, liposomes, and drugs in a gel matrix. This approach enhances gelation kinetics and enables controlled drug release through thermal and magnetic field triggers.
Article
Chemistry, Analytical
Fan Xu, Baijun Dong, Xue Li, Fei Gao, Donglei Yang, Wei Xue, Pengfei Wang
Summary: This study conducted proteomic analysis to profile proteins that bind to DNA materials in human serum, revealing distinctive protein profiles for each DNA material and significant differences in profiles when serum originates from healthy donors vs prostate cancer patients. Furthermore, tethering single-stranded DNA onto DNA material can regulate protein profiles and improve biological performance.
ANALYTICAL CHEMISTRY
(2021)
Article
Instruments & Instrumentation
Ilaria Andreana, Valeria Bincoletto, Paola Milla, Franco Dosio, Barbara Stella, Silvia Arpicco
Summary: Pentamidine is an antimicrobial drug that has potential applications in the treatment of various diseases. However, systemic administration can lead to severe side effects. Nanocarriers have been proposed as a way to reduce these side effects.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Engineering, Chemical
Eric Gaertner, Hyo Yun Jung, Nicolas J. Peter, Gerhard Dehm, Eric A. Jaegle, Volker Uhlenwinkel, Lutz Maedler
Summary: Adding nanosized SiO2 to gas-atomized CoCrFeNi powders can improve flowability and bulk density, with a reduction in dynamic angle of repose and an increase in powder density observed. However, the effect of nanoparticle concentration, mixing time, and Bond-number on powder flowability and porosity should be carefully considered in the additive manufacturing process.
Review
Medicine, Research & Experimental
Yirivinti Hayagreeva Dinakar, Archana Karole, Shabi Parvez, Vikas Jain, Shyam Lal Mudavath
Summary: This article discusses the application of stimuli-responsive nanocarriers in treating lung cancer, including endogenous stimuli-responsive nanocarriers and exogenous stimuli-responsive nanocarriers. These applications help to enhance existing properties and achieve organ-restricted drug delivery.
Article
Multidisciplinary Sciences
Nabil A. Alhakamy, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Wesam H. Abdulaal, Rana B. Bakhaidar, Mohammed O. Alselami, Majed Al Zahrani, Hani M. Alqarni, Adel F. Alghaith, Sultan Alshehri, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Omar D. Al-hejaili, Bander M. Aldhabi, Wael A. Mahdi
Summary: In this study, Alendronate sodium (ALS)-mastoparan peptide (MP) nanoconjugates were successfully formulated and optimized using the Box-Behnken response surface design. The results showed that the optimized ALS-MP nanoconjugates exhibited significantly improved cytotoxic activity towards A549 cells. These findings may provide a new solution for the treatment of lung cancer.
Review
Chemistry, Multidisciplinary
Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios A. Lamprou
Summary: In conventional drug administration, drug molecules may not effectively reach the pathological site, so nanoparticles (NPs) as drug carriers have potential. NPs have a large surface area and quantum properties. Traditional methods for manufacturing NPs have limitations and new methods need to be investigated.
Article
Materials Science, Biomaterials
Zejie Yu, Yi Wang, Miaomiao Cai, Jiachang Chen, Qirong Zou, Quli Fan, Lei Zhang
Summary: A novel detection strategy for dynamic monitoring of drug release was developed using gold nano-triangular sheets. The pronounced spectral shifts in their LSPR scattering spectra can be used to assess drug loading and release and release kinetics.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Nathaly Ortiz Pena, Kondareddy Cherukula, Benjamin Even, Ding-Kun Ji, Sarah Razafindrakoto, Shiyuan Peng, Amanda K. A. Silva, Cecilia Menard-Moyon, Herve Hillaireau, Alberto Bianco, Elias Fattal, Damien Alloyeau, Florence Gazeau
Summary: This study reveals that inhalation of MoS2 nanosheets can induce lung inflammation in mice, but the inflammation is promptly resolved. The study also shows that MoS2 nanosheets can be transported and degraded by extracellular vesicles, which play a crucial role in inflammation resolution.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Zhibo Yu, Nicolas Tsapis, Francois Fay, Liang Chen, Andrii Karpus, Xiangyang Shi, Catherine Cailleau, Samuel Garcia Perez, Nicolas Huang, Juliette Vergnaud, Serge Mignani, Jean-Pierre Majoral, Elias Fattal
Summary: Small interfering RNA (siRNA) shows potential in treating rheumatoid arthritis by inhibiting major cytokines like tumor necrosis factor-alpha (TNF-alpha). Researchers have developed original cationic amphiphilic phosphorus dendrons that can form dendriplexes with TNF-alpha siRNA. These dendriplexes protect siRNA from degradation and enhance macrophage uptake, leading to significant inhibition of TNF-alpha expression and anti-inflammatory effects in in vitro and in vivo models. This opens up important perspectives for using these original amphiphilic dendrons in chronic inflammatory diseases.
Article
Pharmacology & Pharmacy
Mohamed Beladjine, Claire Albert, Maxime Sintes, Ghozlene Mekhloufi, Claire Gueutin, Valerie Nicolas, Alexis Canette, Michael Trichet, Nicolas Tsapis, Laurence Michel, Florence Agnely, Nicolas Huang
Summary: The innovative Pickering emulsions can co-encapsulate two active pharmaceutical ingredients for topical use. The emulsions are stable and biocompatible, with no negative effects on human keratinocytes. These emulsions show promise as a multidrug delivery system for chronic inflammatory skin diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kamila Bohne Japiassu, Francois Fay, Alessandro Marengo, Sebastiao A. Mendanha, Catherine Cailleau, Younes Louaguenouni, Qinglin Wang, Stephanie Denis, Nicolas Tsapis, Thais Leite Nascimento, Eliana Martins Lima, Elias Fattal
Summary: In this study, lipid nanoparticulate platforms loaded with dexamethasone were developed and evaluated. The dexamethasone-loaded liposomes, with sizes below 150 nm, were coated with polyethylene glycol, hyaluronic acid, or a mixture of both to cross the pulmonary mucus layer and target alveolar proinflammatory macrophages expressing CD44. In vitro experiments showed that encapsulated dexamethasone in liposomes, especially in HA-bearing ones, improved anti-inflammatory efficacy compared to the free drug. In vivo data demonstrated that dexamethasone-loaded liposomes exhibited improved consistency in efficacy compared to free dexamethasone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Barbara Tessier, Nicolas Tsapis, Elias Fattal, Laurence Moine
Summary: Glucocorticoids (GC) are commonly used drugs for inflammatory diseases, but their prolonged use can lead to severe side effects. Recent advancements in GC prodrugs and conjugates, administered as free forms or nanoparticles, have improved drug delivery, controlled release, and targeting in inflammatory sites. This review highlights the potential of these novel strategies and discusses their design strategies and recent advances.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Saadat Hussain, Mujeeb Ur-Rehman, Aqsa Arif, Catherine Cailleau, Cynthia Gillet, Rudaba Saleem, Hira Noor, Farwa Naqvi, Almas Jabeen, M. Iqbal Atta-ur-Rahman, M. Iqbal Choudhary, Elias Fattal, Nicolas Tsapis
Summary: New lipidic prodrugs of diclofenac were synthesized by grafting aliphatic chains to diclofenac through an ester bond. The nanoparticles of the prodrugs were successfully formulated and exhibited good stability. The prodrug nanoparticles showed dose-dependent inhibition of TNF-α comparable to standard diclofenac sodium.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Baptiste Robin, Ludivine Mousnier, Hung Le, Nadege Grabowski, David Chapron, Ophelie Bellance-Mina, Nicolas Huang, Florence Agnely, Elias Fattal, Nicolas Tsapis
Summary: Most nanoparticles used for drug delivery are spherical, but elongated particles have advantages in cellular uptake. In this study, we synthesized biocompatible polylactide-b-poly(ethylene glycol) (PLA-PEG) polymers with carboxylate moieties and used them to form worm-like nanoparticles. By adjusting the molar mass of the PLA block, we obtained worm-like nanoparticles with varying aspect ratios. The proportion of worm-like particles increased as the molar mass of the PLA block decreased, contrary to the usual behavior of block polymers. These anisotropic nanoparticles showed increased cellular uptake compared to their spherical counterparts, highlighting their potential for drug delivery applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Mujeeb Ur-Rehman, Franceline Reynaud, Sinda Lepetre, Sonia Abreu, Pierre Chaminade, Elias Fattal, Nicolas Tsapis
Summary: In this study, lipid-drug conjugates (LDCs) of dexamethasone (DXM) with different lipid-drug linkages were synthesized and turned into nanoscale particles. The encapsulation efficacy of LDCs was above 95%, with good stability and no recrystallization observed. Ester and carbonate LDC nanoparticles exerted anti-inflammatory activity, while the carbamate LDC nanoparticles were toxic to macrophages and discarded. The release rate of DXM from ester particles was faster than that from carbonate particles, leading to a lower exposure to DXM from carbonate LDC nanoparticles in pharmacokinetics and biodistribution studies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Rheumatology
Audrey Paoletti, Bineta Ly, Catherine Cailleau, Fan Gao, Marie Pean de Ponfilly-Sotier, Juliette Pascaud, Elodie Riviere, Luxin Yang, Lilian Nwosu, Aziza Elmesmari, Franceline Reynaud, Magali Hita, David Paterson, Julien Reboud, Francois Fay, Gaetane Nocturne, Nicolas Tsapis, Iain B. Mcinnes, Mariola Kurowska-Stolarska, Elias Fattal, Xavier Mariette
Summary: This study demonstrated that the delivery of antagomiR-155-5p encapsulated in PEG liposomes to monocytes and macrophages effectively reduced joint inflammation in murine models of rheumatoid arthritis, suggesting a promising therapeutic strategy for human disease.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Geraldine Landon, Guillaume Phan, Francois Fay, Celine Bouvier-Capely, Elias Fattal
Summary: Decorporating treatment is crucial for internal contamination with radionuclides. The existing therapies often lack effectiveness, and conventional research strategies are time-consuming and costly. Drug repurposing and nanotechnologies offer promising approaches for improving the delivery and efficacy of active substances.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)