Article
Pharmacology & Pharmacy
Chun-En Kuo, Sheng-Feng Hsu, Ching-Chih Chen, Szu-Ying Wu, Yu-Chiang Hung, Chung Y. Hsu, I. -Ju Tsai, Wen-Long Hu
Summary: This study investigated the prevalence and distinctive features of Xue-Fu-Zhu-Yu-Tang (XFZYT) prescriptions using the National Health Insurance Research Database (NHIRD). XFZYT was found to be frequently used to treat pain-related conditions such as chest pain, headache, myalgia, lumbago, and neuralgia. Further clinical trials are suggested to verify the efficacy of XFZYT in pain management.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ying-Jung Tseng, Yu-Chiang Hung, Chun-En Kuo, Chia-Jung Chung, Chung Y. Hsu, Chih-Hsin Muo, Sheng-Feng Hsu, Wen-Long Hu
Summary: This study is the first to identify the most common conditions for which radix Salvia miltiorrhiza (Danshen; RSM) is used in modern Taiwan, showing its key role in treating gynecological diseases such as menstrual disorders, abnormal bleeding from the female genital tract, and menopausal disorders. RSM is often combined with Yan-Hu-Suo and Jia-Wei-Xiao-Yao-San for clinical use. Further research is needed to determine the optimal dosage, efficacy, and safety of RSM.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Po-Yen Lin, Le-Yin Hsu, Hsuan-Lu Alicia Ko, Perng-Haur Wang, Ping-Yi Lin, Lin-Yang Chi
Summary: This study examined the effectiveness of a national pit and fissure sealants (PFS) program in Taiwan. The results showed that children who participated in the program had a reduced risk of caries-related treatments by at least 10%. The presence of retained sealants also contributed to an additional 30% risk reduction.
JOURNAL OF DENTISTRY
(2023)
Review
Public, Environmental & Occupational Health
Po-Chang Lee, Feng-Yu Kao, Fu-Wen Liang, Yi-Chan Lee, Sheng-Tun Li, Tsung-Hsueh Lu
Summary: This paper introduces the laboratory databases established by the Taiwan National Health Insurance Administration (NHIA) since 2015 for research purposes. The databases contain laboratory test results and examination reports, with over 5.64 billion test results for 602 types of tests stored. Researchers are required to develop algorithms to handle the potential differences in data formatting from different hospitals.
CLINICAL EPIDEMIOLOGY
(2021)
Article
Environmental Sciences
Shih-Wei Chen, Han-Jie Lin, Stella Chin-Shaw Tsai, Cheng-Li Lin, Chung Y. Hsu, Tsai-Ling Hsieh, Chuan-Mu Chen, Kuang-Hsi Chang
Summary: This study aims to investigate the association between air pollution and chronic rhinosinusitis (CRS). Using databases from Taiwan's National Health Insurance and Air Quality Monitoring, the study found that higher levels of air pollutants, such as PM2.5, NO2, and PM10, were significantly associated with increased CRS risk.
Article
Pharmacology & Pharmacy
Chien-Chen Huang, Yu-Cih Yang, Iona MacDonald, Ching-Yuan Lai, Cheng-Hao Tu, Yi-Hung Chen
Summary: The study in Taiwan found that chemotherapy is a risk factor for stroke in cancer patients, but the use of traditional Chinese medicine can significantly reduce this risk and decrease the mortality rate associated with chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Ni Tien, Tien-Yuan Wu, Cheng-Li Lin, Chia-Jui Wu, Chung-Y Hsu, Yi-Jen Fang, Yun-Ping Lim
Summary: Patients with inflammatory bowel disease are at a higher risk of developing cardiovascular diseases due to chronic inflammation and hyperlipidemia. However, the use of inflammatory bowel disease medications can lower the risk of developing hyperlipidemia.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Shih-Yi Lin, Yu-Cih Yang, Jun-Wei Su, Jie-Sian Wang, Chang-Cheng Jiang, Chung-Y. Hsu, Chia-Hung Kao
Summary: A study in Taiwan found that women exposed to higher concentrations of NOX, NO, NO2, and CO showed a higher incidence of preeclampsia.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Ling- Hsu, Jen-Wen Chen, Dong-Tsamn Lin, Ying-Sheng Hung, Sheng-Mou Hou
Summary: IVIG utilization in Taiwan has shown an annual growth rate of 10% over the past decade, with primary use in pediatrics, rheumatology, and hematology/oncology. Top indications include primary and secondary immune deficiency, Kawasaki disease, and thrombocytopenia.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Paula Francezca Padua, Chia-Chen Lin, Hui-Tzu Chien, Chi-Kuan Young, Chang-Fu Kuo, Lai-Chu See, Shue-Fen Luo, Lu-Hsiang Huang, Shiang-Fu Huang
Summary: Head and neck cancer (HNC) incidence is on the rise globally. Research shows that individuals with an affected first-degree relative have an increased risk of developing HNC, especially if the relative is a twin. This highlights the likely contribution of genetic factors in cancer development.
Article
Infectious Diseases
Ya-Wei Weng, Susan Shin-Jung Lee, Hung-Chin Tsai, Chih-Hui Hsu, Sheng-Hsiang Lin
Summary: Neurological disorders are still common in HIV-infected individuals in Taiwan. A nomogram was established using nine clinical factors and comorbidities to estimate the risk of developing a neurological disorder in this population.
BMC INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Tien-Yu Chen, Terry B. J. Kuo, Chi-Hsiang Chung, Nian-Sheng Tzeng, Hsiao-Ching Lai, Wu-Chien Chien, Cheryl C. H. Yang
Summary: This study aimed to explore the association between anxiety disorders and obstructive sleep apnea (OSA) using Taiwan's nationwide database. The results showed a higher prevalence of previous anxiety exposure in OSA patients, particularly in males aged 18 to 64 with hypertension, indicating a higher risk of OSA comorbidity in anxiety patients.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierre Verdot, Paul Calame, Hadrien Winiszewski, Franck Grillet, Alexandre Malakhia, Zaher Lakkis, Maxime Ronot, Sebastien Pili-Floury, Gael Piton, Eric Delabrousse
Summary: The absence of bowel wall enhancement remains the key CT feature for diagnosing transmural necrosis in non-occlusive mesenteric ischemia, regardless of the bowel segment involved. Inter-reader agreement of CT features is lower in the colon compared to the small bowel. Proximal TN is associated with poorer overall survival.
EUROPEAN RADIOLOGY
(2021)
Article
Immunology
Daniel Tzu-Li Chen, Jane Pei-Chen Chang, Szu-Wei Cheng, Hui-Chih Chang, Jong-Hau Hsu, Hen-Hong Chang, Wei-Che Chiu, Kuan-Pin Su
Summary: The study revealed that patients with Kawasaki disease were more likely to have comorbid psychiatric disorders, such as autism spectrum disorders and attention deficit hyperactivity disorder. Additionally, the use of IVIG anti-inflammatory treatment may have potential prophylactic effects against the development of psychiatric disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Maw Ho, Chi-Ling Chen, Chia-Hao Chang, Meng-Rui Lee, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee
Summary: IL-22 binding protein (IL-22BP) was found to be a protective biomarker against the development of drug-induced liver injury (DILI) in tuberculosis patients, while additional risk factors like IP-10 and sCD163 proved to be effective in predicting the occurrence of DILI.
Editorial Material
Surgery
Chao-Ming Hung, Po-Huang Lee, Hui-Ming Lee, Chong-Chi Chiu
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Editorial Material
Surgery
Chong-Chi Chiu, Po-Huang Lee, Chen-Fuh Lam, Li-Ren Yeh, Cheuk-Kwan Sun
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Cheng-Maw Ho, Chi-Chuan Yeh, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee
Summary: This study investigated the impact of online learning on curiosity stimulation and short-term learning outcomes in medical education. It was found that the level of curiosity in medical students after learning each concept through online videos significantly correlated with the degree to which the concept was learned. Students spent a median of 1.6 hours online, and pause frequency correlated with curiosity in certain concepts.
FRONTIERS IN MEDICINE
(2021)
Article
Health Care Sciences & Services
Hui-Ying Lin, Cheng-Maw Ho, Pei-Yin Hsieh, Min-Heuy Lin, Yao-Ming Wu, Ming-Chih Ho, Po-Huang Lee, Rey-Heng Hu
Summary: The study retrospectively reviewed the time and risk factors associated with interruptions in the live donor liver transplantation (LDLT) process, finding that patients with hepatitis B virus, encephalopathy, hypertension, and increased total bilirubin were at higher risk of not undergoing LDLT. Major barriers included patients' critical illnesses, donors' physical conditions, motivation for live donation, and stability on the waiting list.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Editorial Material
Surgery
Hon-Yi Shi, Po-Huang Lee, I-Ting Tsai, Nan-Han Lu, Chong-Chi Chiu
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Letter
Surgery
Chao-Ming Hung, Po-Huang Lee, Chi-Ming Tai, Wen-Lun Wang, Yi-Ling Wu, Chong-Chi Chiu
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Cheng-Maw Ho, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Rey-Heng Hu
Summary: This study investigated the changes in transplantability between primary and recurrent Hepato-cellular carcinoma (HCC) after hepatic resection (HR) and identified risk factors for nontransplantable recurrence (NTR). The study found that tumor diameter, resection extent, pathological grade, microvascular invasion, and early recurrence were associated with NTR. The overall transplantable pool increased after HR, suggesting that liver transplantation may not be necessary for some patients.
Article
Gastroenterology & Hepatology
Huey-Huey Chua, Mei-Hwei Chang, Ya-Hui Chen, Daw-Jen Tsuei, Yung-Ming Jeng, Po-Huang Lee, Yen-Hsuan Ni
Summary: We identified RBMY as a predictive biomarker for hepatocellular carcinoma metastasis. Provirus integration phosphorylates RBMY, leading to stabilized and translocated RBMY that promotes epithelial-mesenchymal transition and mitochondrial dysregulation in hepatocellular carcinoma, resulting in distant metastasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ping-Jui Yu, Cheng-Maw Ho, Chih-Yang Hsiao, Yao-Ming Wu, Ming-Chih Ho, Po-Huang Lee, Rey-Heng Hu
Summary: Primary sclerosing cholangitis (PSC) is a rare disease in Asia and little research has been conducted on this ethnic group, especially in wait-listed patients for liver transplantation (LT). This study aimed to investigate the prognosis and outcomes of wait-listed patients with PSC in an Asian transplant center. The results showed that female PSC patients had higher AST to platelet ratio index scores and bilirubin levels compared to males, and were more likely to present with decompensating events. Female gender and LT were identified as protective factors for overall survival in multivariable analysis.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Rey-Heng Hu, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Cheng-Maw Ho
Summary: This retrospective study analyzed 726 patients who experienced intrahepatic recurrence after primary hepatectomy for hepatocellular carcinoma (HCC). The results showed that both radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) were effective in improving long-term survival, particularly in patients with hepatitis B virus (HBV). Antiviral treatment complemented the survival of patients with hepatitis C virus (HCV) after RFA, especially in late first recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Education & Educational Research
Cheng-Maw Ho, Chi-Chuan Yeh, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee
Summary: This study explored medical students' preferences for synchronous class formats and their experiences with preclass online video learning. The results showed that students who chose face-to-face and HyFlex formats were more concerned about learning efficiency, focus concentration, and course attractiveness. However, the choice of class format did not affect short-term learning outcomes.
MEDICAL EDUCATION ONLINE
(2023)
Letter
Surgery
Chao-Ming Hung, Kuo-Chuan Hung, Po-Huang Lee, Kang Lu, Meng-Che Hsieh, Chong-Chi Chiu
BRITISH JOURNAL OF SURGERY
(2022)
Letter
Surgery
Chao-Ming Hung, Kuo-Chuan Hung, Po-Huang Lee, I-Ting Tsai, Hui-Ming Lee, Chong-Chi Chiu
BRITISH JOURNAL OF SURGERY
(2022)
Letter
Surgery
Chao-Ming Hung, Po-Huang Lee, Chao-Sung Chang, Kun-Ming Rau, Jung-Fa Tsai, Chong-Chi Chiu
BRITISH JOURNAL OF SURGERY
(2022)