期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 486, 期 1-2, 页码 226-231出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2015.04.005
关键词
Vancomycin; Silica; Covalent bonding; Ionic bonding; Controlled release; Biological activity
资金
- National Science Centre of Poland [2011/03/B/ST5/01573]
Vancomycin was immobilized on three different organically functionalized silicas. The materials obtained were used for a controlled release of the antibiotic. The influence of the type of chemical bond on the in vitro drug release was investigated. A weak ionic bonding caused burst release of the drug within one day. A covalent bonding resulted in a slowdown in the release process and uniformity of dosage release. For these two carriers, biological activity of the drug was retained because the minimal inhibitory concentration values against the strains tested were similar to that of a free form of the drug (about 2 mg/mL). A strong ionic bonding of vancomycin adversely affected both the drug release, as well as its biological activity. A strong base on the surface of the silica prevented disconnection of the antibiotic which then became ineffective. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据