Article
Cell & Tissue Engineering
Jacopo Morroni, Anna Benedetti, Lorenza Esposito, Marco De Bardi, Giovanna Borsellino, Carles Sanchez Riera, Lorenzo Giordani, Marina Bouche, Biliana Lozanoska-Ochser
Summary: Muscle injury has a lasting effect on muscle stem cells, making them respond faster to subsequent injuries and contribute to accelerated muscle regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell Biology
Xingyu Wang, Lan Zhou
Summary: Skeletal muscle plays a crucial role in physical activity and energy metabolism. Satellite cells, residing in skeletal muscle, are essential for maintaining homeostasis and regeneration post-injury. Macrophages, a diverse group of immune cells, are key regulators in the interaction with myogenic cells for proper muscle regeneration under both normal and diseased conditions like muscular dystrophy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Physiology
Fengjiao Huo, Qing Liu, Hailiang Liu
Summary: This review focuses on the etiology, assessment, and treatment of sarcopenia, as well as the functional and regulatory mechanisms of muscle satellite cells. Patients with sarcopenia often exhibit dysregulation of muscle satellite cell homeostasis, highlighting the importance of improving muscle satellite cell function in the treatment of sarcopenia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Chung-Ju Yeh, Kristina M. Sattler, Christoph Lepper
Summary: Somatic stem cells, specifically satellite cells in skeletal muscle tissue, play a crucial role in maintaining tissue homeostasis and regenerating injured muscle fibers. These cells are maintained in a quiescent state during adulthood but are rapidly activated upon injury to produce myoblasts, which differentiate and fuse to regenerate the damaged muscle fibers. Intrinsic gene regulatory networks control the quiescent state and activation, proliferation, differentiation, and self-renewal of satellite cells. Molecular signals from the environment of satellite cells determine their behavior in terms of remaining quiescent or initiating regenerative myogenesis. This review provides a concise overview of the major intercellular signaling pathways involved in regulating satellite cells during quiescence and skeletal muscle regeneration after injury.
Article
Biochemistry & Molecular Biology
Hiroyuki Iio, Tadahiko Kikugawa, Yuichiro Sawada, Hiroshi Sakai, Shuhei Yoshida, Yuta Yanagihara, Aoi Ikedo, Noritaka Saeki, So-ichiro Fukada, Takashi Saika, Yuuki Imai
Summary: Dnmt1 plays a crucial role in skeletal muscle regeneration, as indicated by the significant decrease in muscle weight and cell number in Dnmt1 knockout mice. RNA sequencing analysis revealed alterations in gene expression related to cell adhesion and apoptosis in satellite cells from knockout mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Jingyao Deng, David J. Cohen, Eleanor L. Sabalewski, Christine Van Duyn, D. Scott Wilson, Zvi Schwartz, Barbara D. Boyan
Summary: The study demonstrates that the delivery of semaphorin 3A (sema3A) enhances osseointegration in T2DM rats with impaired bone quality, improving osteoblast differentiation and increasing bone contact with implants. This suggests the potential of sema3A as a treatment option for osseointegration issues in T2DM patients.
ACTA BIOMATERIALIA
(2023)
Review
Developmental Biology
Brittany C. Collins, Gabrielle Kardon
Summary: Vertebrate skeletal muscle is composed of multinucleate myofibers surrounded by muscle connective tissue, and can robustly regenerate following injury through satellite cells. Satellite cells and FAPs are heterogeneous cell populations, with current understanding focusing on gene expression, anatomical location, age, and timing during the regenerative process.
Article
Peripheral Vascular Disease
Yang Fu, Jian-wei Liu, Ji Wu, Zu-xiang Wu, Juan Li, Hui-fang Ji, Ning-peng Liang, Hong-jin Zhang, Ze-qun Lai, Yi-Fei Dong
Summary: This study investigated the effects of inhibiting Sema3A on LPS-induced vascular injury. The results showed that inhibiting Sema3A improved vascular dysfunction and pathological injury caused by LPS. It also suppressed vascular endothelial cells activation, inflammation, and oxidative stress, suggesting that inhibiting Sema3A could be a potential therapeutic strategy for septic vascular injury or atherosclerosis.
MICROVASCULAR RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ziyu Chen, HaiQiang Lan, ZhaoHong Liao, JingWen Huang, XiaoTing Jian, Jijie Hu, Hua Liao
Summary: This review summarizes the role and functioning process of Treg cells in the treatment of skeletal muscle diseases, emphasizing their importance in skeletal muscle repair and providing new research perspectives.
CELL AND BIOSCIENCE
(2022)
Review
Medicine, General & Internal
Yizhen Sang, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada
Summary: Kidney diseases are a global public health issue with limited treatment options. Semaphorin 3A (SEMA3A) plays a crucial role in kidney pathophysiology, with excess expression worsening kidney injury and inhibition of SEMA3A potentially ameliorating kidney damage, making it a potential therapeutic target for kidney diseases.
Article
Cell Biology
Antonio Sancho-Munoz, Maria Guitart, Diego A. Rodriguez, Joaquim Gea, Juana Martinez-Llorens, Esther Barreiro
Summary: In the vastus lateralis of sarcopenic COPD patients, there was an increase in myostatin content, activated satellite cells, hybrid fiber proportions, TUNEL-positive cells, internal nuclei, and muscle damage. Conversely, muscle strength, numbers of Pax-7+/Myf-5- cells, and slow- and fast-twitch myofiber areas decreased. Muscle regeneration markers were lower in both sarcopenic and nonsarcopenic patients compared to controls. However, in severe COPD patients, regardless of sarcopenia status, there was evidence of muscle regeneration activation along with significant alterations in muscle phenotype and damage, and increased myostatin levels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Xinyue Zhang, Zhenqi Yang, Demao Zhang, Mingru Bai
Summary: This comprehensive review article aims to elucidate the recent advances in understanding SEMA3A in the oral system, encompassing nerve formation, periodontitis, pulpitis, apical periodontitis, and oral squamous cell carcinoma. The article explores the novel function of SEMA3A in inflammatory immunomodulation and alveolar bone formation during oral infectious diseases, enhancing our comprehension of SEMA3A's role in oral biology and opening up possibilities for modulatory approaches and potential treatments in oral diseases.
Article
Cell Biology
Iwona Bronisz-Budzynska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Magdalena Madej, Alicja Jozkowicz, Agnieszka Loboda, Jozef Dulak
Summary: Increased oxidative stress can hinder skeletal muscle regeneration and affect muscle satellite cells (mSCs) activity. NRF2 transcription factor plays an important role in muscle cell biology by promoting myoblast proliferation and viability, reducing reactive oxygen species production, and inhibiting myoblast differentiation. NRF2 is also crucial for the viability of mSCs.
Article
Geriatrics & Gerontology
Kyung Min Kim, Gi Don Yoo, Woong Heo, Ho Taek Oh, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: This study reveals that the transcriptional co-activator TAZ promotes muscle regeneration by activating satellite cells. TAZ interacts with Pax7 to induce Myf5 expression and activates the mammalian target of rapamycin signaling pathway. Additionally, the p38 MAPK-TAZ signaling axis is found to be crucial for muscle regeneration.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xiaochi Chang, Fengyi Zhou, Lingxue Bu, Nan Wang, Jing Deng, Shuai Wang
Summary: Hypoxia inhibits osteogenesis of PDLSCs, while Sema3A attenuates the hypoxia suppression of osteogenesis in PDLSCs.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biology
Dan Yang, Hideaki Oike, Mitsuhiro Furuse, Shinobu Yasuo
Summary: The study found that the circadian clock in NIH3T3 cells can respond to periodic stimulation cycles of dexamethasone, entraining to 22 and 24-hour cycles during the stimulation period. Irregular dexamethasone treatment disrupted the expression of several clock and cell cycle genes, causing overall upregulation and phase shifts. Regular stimulation with dexamethasone also resulted in upregulation of certain genes, showing different effects compared to irregular treatment.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Veterinary Sciences
Yume Kitagawa, Kaho Hayakawa, Daichi Oikawa, Kazuki Ikeda, Maki Ikeda, Daiki Harada, Mitsuhiro Furuse
Summary: In modern society, stress caused by relationships and emotions is a significant social issue. This study aimed to investigate the impact of repeated restraint stress on the fatty acid composition and amino acid concentration in the skin of ICR mice. The results showed changes in fatty acid composition with an increase in saturated fatty acids and a decrease in unsaturated fatty acids, potentially leading to skin inflammation.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Z. Elhussiny, Phuong V. Tran, Yuriko Tsuru, Shogo Haraguchi, Elizabeth R. Gilbert, Mark A. Cline, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: The study aimed to investigate the effects of centrally administered taurine on rectal temperature, behavioral responses, and brain amino acid metabolism under stress conditions and co-injection of corticotropin-releasing factor (CRF). The results showed that taurine attenuated CRF-induced hyperthermia and stress behaviors in neonatal chicks. Furthermore, taurine altered the concentrations of amino acids in the brain, likely by repartitioning them to different metabolic pathways to cope with acute stress.
Article
Pharmacology & Pharmacy
Mohamed Z. Elhussiny, Haruka Nishimura, Phuong Tran, Shogo Haraguchi, Elizabeth R. Gilbert, Mark A. Cline, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: The objective of this study was to investigate the mechanism of brain monoamine metabolism in taurine-induced hypothermia and appetite suppression. Central taurine activates dopamine-beta-hydroxylase and tryptophan hydroxylase to produce norepinephrine and 5-HT, which then induces hypothermia and anorexia, respectively.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Haruka Nishimura, Ying Wang, Mohamed Z. Elhussiny, Phuong V. Tran, Shogo Haraguchi, John F. Cockrem, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: This study found that central injection of NPY can regulate heat stress response in the spleen of chicks, decreasing body temperature and enhancing antioxidative status. This provides important evidence for further investigation of the role of central NPY in immune organs under heat stress conditions.
NEUROSCIENCE LETTERS
(2022)
Article
Food Science & Technology
Masaya Ogata, Jumpei Uchiyama, Abdulatef M. Ahhmed, Seiichi Sakuraoka, Satoshi Taharaguchi, Ryoichi Sakata, Wataru Mizunoya, Shiro Takeda
Summary: The study investigated the inherent bacteria contributing to ACE inhibitory and antioxidant activities in dry-cured meat products. Results showed that different species of Lactobacillales order were important for the functional activities of the products.
Article
Biochemistry & Molecular Biology
Mohamed Z. Elhussiny, Phuong Tran, Ying Wang, Yoshimitsu Ouchi, Shogo Haraguchi, Elizabeth R. Gilbert, Mark A. Cline, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: The study found that central injection of taurine can rapidly change the concentrations of free amino acids in the brain and plasma, which may play a role in thermoregulation, food intake, and stress response in chicks.
Article
Agriculture, Dairy & Animal Science
Phuong Tran, Mohamed Z. Elhussiny, Yuriko Tsuru, Ying Wang, Guofeng Han, Vishwajit S. Chowdhury, Mitsuhiro Furuse
Summary: Ornithine has been identified as a potential satiety signal in the brains of neonatal chicks. The study found that co-injection of the neuropeptide Y (NPY) and ornithine attenuated the orexigenic effect induced by NPY and modified the anabolic effect of central NPY. These findings suggest that brain ornithine interacts with NPY to regulate food intake in neonatal chicks.
JOURNAL OF POULTRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tsubasa Ihara, Mizuki Hamada, Mitsuhiro Furuse
Summary: Heredity is a major factor in the pathogenesis of depression, but the specific mechanism is not fully understood. The present study suggests that the paternal strain has a significant impact on locomotor activity and depression-like behavior, potentially through the dysregulation of amino acid metabolism in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Shoko Sawano, Misaki Fukushima, Taiki Akasaka, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi, Wataru Mizunoya
Summary: Skeletal muscle atrophy due to inactivity leads to changes in gene expression. However, little is known about the patterns of up-and downregulated gene expression during long-term and equilibrated muscle atrophy. This study used RNA-Seq to examine the changes in gene expression in long-term denervated mouse muscles. The results revealed that the expression of several genes, including E230016M11Rik, was significantly upregulated in both soleus and extensor digitorum longus (EDL) muscles.
Article
Agriculture, Dairy & Animal Science
Shiro Takeda, Abdulatef M. Ahhmed, Kazuki Sogawa, Saki Mouri, Sakurako Kaneko, Ryoichi Sakata, Wataru Mizunoya
Summary: Venison, a type of game meat, contains bioactive peptides with antioxidative properties. The study investigated the antioxidant activity of venison treated by in vitro cooking and digestion. The results showed that the digested venison had increased antioxidant activity and contained two peptides with high DPPH-RS activities.
ANIMAL SCIENCE JOURNAL
(2023)
Article
Cell Biology
Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Takashi Nakashima, Shoko Okuda, Yoshitaka Manabe, Shoko Sawano, Wataru Mizunoya, Ryuki Kaneko, Sakiho Tanaka, Takahiro Maeno, Yuji Matsuyoshi, Miyumi Seki, So Kuwakado, Kahona Zushi, Nasibeh Daneshvar, Mako Nakamura, Takahiro Suzuki, Kenji Sunagawa, Judy E. Anderson, Ronald E. Allen, Ryuichi Tatsumi
Summary: Mechanical perturbation triggers activation of myogenic stem cells, but with aging, extracellular HGF undergoes nitration and loses its binding with c-met, disturbing muscle homeostasis. These findings highlight the inhibitory effects of HGF nitration on myogenic stem cell dynamics and contribute to understanding age-related muscle atrophy and impaired regeneration.
Article
Biochemistry & Molecular Biology
Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Miyumi Seki, Sakiho Tanaka, Yuji Matsuyoshi, Takashi Nakashima, Shoko Sawano, Wataru Mizunoya, Takahiro Suzuki, Mako Nakamura, Judy E. Anderson, Ryuichi Tatsumi
Summary: Protein tyrosine residue nitration is associated with changes in protein activity and function, and can be used to monitor the progression of pathological disorders. This study found that nitration affects muscle growth and regeneration, specifically impacting the functionality of hepatocyte growth factor. Nitration may perturb the dynamics of myogenic stem cells, leading to the progression of muscular disorders.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Veterinary Sciences
Emi Taniguchi, Ayumi Hattori, Kaito Kurogi, Yukihiro Hishida, Fumiko Watanabe, Mitsuhiro Furuse, Shinobu Yasuo
Summary: The study found that L-ornithine can stimulate the release of GH in mice. After oral administration of L-ornithine, the increase in GH release was first observed 150 minutes later and lasted for more than 90 minutes. This increase was delayed compared to the reported levels of L-ornithine in plasma and tissues.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Miyumi Seki, Sakiho Tanaka, Yuji Matsuyoshi, Takashi Nakashima, Shoko Sawano, Wataru Mizunoya, Takahiro Suzuki, Mako Nakamura, Judy E. Anderson, Ryuichi Tatsumi
Summary: This study investigated the impact of protein tyrosine residue nitration on muscle growth, regeneration, and pathological disorders. The findings suggest that nitration disrupts the function of hepatocyte growth factor and may stimulate the progression of muscular disorders and diseases.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)