Article
Agriculture, Dairy & Animal Science
J. Wozniak, W. Loba, P. Iskrzak, M. Pszczola, J. Wojtczak, M. Switonski, J. Nowacka-Woszuk
Summary: Umbilical hernia (UH) is a common defect in pigs, which affects their welfare and causes economic loss. This study aimed to investigate the association between UH and DNA variants in the CAPN9, OSM, ITGAM, and NUGGC genes. The study analyzed SNPs in CAPN9, OSM, and ITGAM genes and detected differences in allele frequencies for four SNPs in CAPN9. Haplotype analysis revealed that certain haplotypes in OSM and ITGAM genes were associated with a reduced risk of UH in pigs.
Article
Veterinary Sciences
David Conrad, Alexandra Kehl, Christoph Beitzinger, Thomas Metzler, Katja Steiger, Nicole Pfarr, Konrad Fischer, Robert Klopfleisch, Heike Aupperle-Lellbach
Summary: This study aimed to detect mutant genes in digital melanoma and found that canine digital melanoma differs from canine oral melanoma and human melanoma, especially in the proportion of RAS mutations.
VETERINARY SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
L. Guo, H. Sun, Q. Zhao, Z. Xu, Z. Zhang, D. Liu, Q. R. Qadri, P. Ma, Q. Wang, Y. Pan
Summary: The study aims to explore genetic positive selection signatures within the AQ pig population, investigate underlying genetic mechanisms, and identify potential genes related to meat quality, disease resistance, and reproduction traits.
Article
Fisheries
Xin He, Yushan Liao, Zexin Yang, Hongxing Liu, Shi Wang, Yongbo Bao
Summary: The blood clam Tegillarca granosa is a commercially important bivalve species. This study conducted genome-wide association studies and identified 39 SNP markers associated with the growth traits of T. granosa. Additionally, 27 candidate genes potentially involved in T. granosa growth were identified. Enrichment analysis highlighted the role of transmembrane transport, immune system function, protein family metabolism, and JAK-STAT signaling pathways in T. granosa growth.
Article
Engineering, Environmental
Wang Luo, You Wu, Xueping Chen, Li Zhang, Li Wang, Dan Bai, Qian Liu, Ting Wang, Hongyan Yu, Yaxing Xie, Yixin Fu, Zhongzhong Wang, Yujun Yang, Junjie Li, Yongcan Guo, Ke Lv, Guoming Xie
Summary: Combinations of statistically related SNPs, known as haplotypes, can provide richer medical and genetic information than isolated SNPs. However, determining whether SNP loci separated by thousands of bases are located on the same chromosome is challenging and time-consuming. This study developed a mathematical logic-based algorithm, using DNA nanotechnology and thermodynamic mechanisms, to simplify the analysis of long-range haplotypes. The results have the potential to contribute to the development of personalized applications of haplotype analysis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Ning Ma, Ao Jin, Yitong Sun, Yiyao Jin, Yucheng Sun, Qian Xiao, XuanYi Sha, Fengxue Yu, Lei Yang, Wenxuan Liu, Xia Gao, Xiaolin Zhang, Lu Li
Summary: This study focused on the relationship between single nucleotide polymorphisms (SNPs) of MMR genes and hepatocellular carcinoma (HCC) associated with chronic hepatitis B virus (HBV) infection. The findings revealed that 12 SNPs were associated with genetic susceptibility to HCC. Additionally, interactions between genes and the impact of SNPs on genetic susceptibility to HCC were also observed. These findings provide new insights for further exploration of the etiology and pathogenesis of HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jairo Lumpuy-Castillo, Claudia Vales-Villamarin, Ignacio Mahillo-Fernandez, Iris Perez-Nadador, Leandro Soriano-Guillen, Oscar Lorenzo, Carmen Garces
Summary: This study analyzed the relationship between ACE2 polymorphisms and cardiovascular risk factors in children, and found that certain ACE2 mutations are associated with obesity and hyperlipidemia in females.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Francesca Taranto, Giacomo Mangini, Monica Marilena Miazzi, Piergiorgio Stevanato, Pasquale De Vita
Summary: Studying the genetic basis of polyphenol oxidases (PPO) related traits is crucial for crop genetic improvement. By analyzing a tetraploid wheat collection using 90K wheat SNP iSelect assay, 23 marker-trait associations related to PPO activity were detected, and two haplotypes associated with low and high PPO activity were identified. A reliable marker for marker assisted selection was developed, and genetic divergence between T. turgidum subspecies was evaluated using the detected associations.
Article
Biochemistry & Molecular Biology
David Wragg, Sonia E. Eynard, Benjamin Basso, Kamila Canale-Tabet, Emmanuelle Labarthe, Olivier Bouchez, Kaspar Bienefeld, Malgorzata Bienkowska, Cecilia Costa, Ales Gregorc, Per Kryger, Melanie Parejo, M. Alice Pinto, Jean-Pierre Bidanel, Bertrand Servin, Yves Le Conte, Alain Vignal
Summary: Honey bee subspecies originate from specific geographical areas and have been imported to different regions. To better understand Western European honey bee populations, researchers conducted a genome sequence and SNP genotype analysis.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Agriculture, Dairy & Animal Science
Sonali, Anuradha Bhardwaj, Unnati Unnati, Varij Nayan, Ram Avatar Legha, Tarun Kumar Bhattacharya, Yash Pal, Shiv Kumar Giri
Summary: The aim of this study was to identify and characterize novel polymorphisms or SNPs in the DMRT3 gene in Indian horse and donkey breeds. The DMRT3 gene was sequenced and characterized in 72 Indian horses and 33 Indian donkeys, revealing a SNP at position 878 in horses and identical SNPs at positions 878 and 942 in donkeys. These mutations have a major impact on gaitedness in horses and are present at a high frequency in gaited breeds and horses bred for harness racing.
ANIMAL BIOTECHNOLOGY
(2023)
Review
Genetics & Heredity
Peter de Knijff
Summary: This article reviews the history of using Y-chromosome polymorphisms in forensic investigations and discusses several often overlooked factors that influence the proper use and interpretation of Y-chromosome information.
Article
Fisheries
Baohua Duan, Tongxu Kang, Haifu Wan, Shumei Mu, Yueqiang Guan, Weibiao Liu, Zejian Li, Yang Tian, Yuqin Ren, Xianjiang Kang
Summary: The SIF gene in the swimming crab (Portunus trituberculatus) was investigated to understand its biological function. The study found that the SIF gene had higher expression in the fast-growing group compared to the slow-growing group, and it was ubiquitously expressed in various tissues, with the highest expression in the heart. Additionally, four SNPs in the SIF gene were found to be significantly associated with growth traits in the swimming crab.
AQUACULTURE REPORTS
(2023)
Article
Plant Sciences
Alejandro Carmona, Josefa Rubio, Teresa Millan, Juan Gil, Jose V. Die, Patricia Castro
Summary: Ascochyta blight, caused by the fungal pathogen Ascochyta rabiei, is a significant threat to chickpea cultivation worldwide. This study identified four genomic regions associated with Ascochyta blight resistance, among which the LOC101507066 gene showed the most potential as a candidate gene.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Oncology
Gabriela Mattevi Almeida, Ana Clara Castilho, Douglas Adamoski, Karin Braun-Prado
Summary: MDM4 plays an important role in cell proliferation, DNA repair, and apoptosis regulation, and its overexpression and amplification lead to cancer formation and poor prognosis. The association between different MDM4 SNPs and solid tumor risk has conflicting conclusions across different populations, cancer types, and risk genotypes. Distinct haplotype patterns in different populations may affect the association between MDM4 SNPs and cancer risk.
Article
Agriculture, Dairy & Animal Science
Riccardo Moretti, Andrea Criscione, Federica Turri, Salvatore Bordonaro, Donata Marletta, Bianca Castiglioni, Stefania Chessa
Summary: To protect the interests of producers and consumers, reliable traceability tools should be developed. Molecular markers based on DNA can be a solution, as DNA can be easily extracted from various animal products and is not degraded during processing. The aim of this study was to identify a small number of DNA mutations to trace the origin of Italian Nero Siciliano pig and its derived products.