Article
Agronomy
Piera Iommelli, Federico Infascelli, Nadia Musco, Micaela Grossi, Maria Ferrara, Fiorella Sarubbi, Biagio D'Aniello, Pietro Lombardi, Raffaella Tudisco
Summary: This study compared the effects of two different diets on buffalo meat quality and SCD gene expression in adipose tissue, revealing important differences between buffalo and bovine species, highlighting the need for specific research on buffalo.
Article
Agriculture, Dairy & Animal Science
Laura Sarri, Joaquim Balcells, Ahmad Reza Seradj, Ramona N. Pena, Gustavo A. Ramirez, Marc Tor, Gabriel de la Fuente
Summary: Fat metabolism is an important process in meat production companies, which affects the quality of meat. The source and incorporation rate of fat differ in different growth phases. The liver plays a critical role in fat metabolism during the fattening phase. Leaner pigs rely more on dietary fatty acids for fat deposition compared to fatter pigs. The activity of stearoyl-CoA desaturase is higher in the fattening phase.
Article
Chemistry, Analytical
Shanshan Jia, Shao Chang, Lin Zhang, Zhengwei Gui, Linhui Liu, Zhenglan Ma, Shuyu Li, Xingchen Huang, Hongying Zhong
Summary: A photocatalytic technique has been developed for in situ mass spectrometric identification and spatial imaging of positional isomers of lipids. It involves the use of gold nanowires to transfer plasmonic hot electrons, generating hydroxyl radicals that cause bond cleavages. The technique can determine the locations of C=C bonds through diagnostic fragment ions produced by collision or auto-fragmentation.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kinga Tibori, Gabriella Orosz, Veronika Zambo, Peter Szelenyi, Farkas Sarnyai, Viola Tamasi, Zsolt Ronai, Judit Matyasi, Blanka Toth, Miklos Csala, Eva Kereszturi
Summary: Disturbances in lipid metabolism caused by excessive food intake and a sedentary lifestyle are major risks for metabolic disorders. The enzyme SCD1 plays an important role in these diseases by catalyzing the synthesis of unsaturated fatty acids. Studies have shown that increased activity or over-expression of SCD1 is a contributing factor for type 2 diabetes mellitus. This research investigated the impact of a common genetic variant on SCD1 function and found that the variant could contribute to the development of obesity-related metabolic disorders, including type 2 diabetes mellitus, by increasing intracellular levels of SCD1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Waseem K. Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Kenneth J. Rhodes, Vikram Khurana, Robert H. Scannevin, Chee Yeun Chung
Summary: Currently, there is no preventive or disease-modifying therapy available for Parkinson's Disease (PD). The failure of clinical trials calls for a re-evaluation of pre-clinical models that better replicate disease mechanisms and predict clinical outcomes. Patient-derived induced pluripotent stem cell (iPSC) models have recently emerged as attractive options to mimic disease-relevant neuropathology in vitro without artificially overexpressing disease-related proteins. In this study, iPSCs derived from early-onset PD patients with specific mutations were utilized to generate a three-dimensional cortical neurosphere model. The model showed alterations in fatty acid profiles and increased levels of pathogenic proteins, which could be attenuated by a small molecule inhibitor. These findings suggest that the 3D cortical neurosphere model is a useful tool for investigating PD and testing potential therapeutics.
Article
Biochemistry & Molecular Biology
Bing-Yen Wang, Yuan-Yen Chang, Li-Yen Shiu, Yi-Ju Lee, Yu-Wei Lin, Yu-Shen Hsu, Hsin-Ting Tsai, Sung-Po Hsu, Li-Jen Su, Meng-Hsiu Tsai, Jing-Hong Xiao, Jer-An Lin, Chang-Han Chen
Summary: This study systematically investigated the expression patterns and clinical outcomes of SCD1 in multiple human cancers and found that SCD1 is dysregulated in several types of cancers and acts as a diagnostic biomarker. Using ESCC as an example, it was found that SCD1 is upregulated in ESCC tumor tissues and is associated with clinicopathological characteristics and poor survival outcomes. Additionally, the study revealed the potential therapeutic target of the miR-181a-5p/SCD1 axis for ESCC treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Julia H. Goedecke, Elin Chorell, Paul J. van Jaarsveld, Ulf Riserus, Tommy Olsson
Summary: This study examined ethnic differences in serum fatty acid composition and desaturase indices among black and white South African women, finding that despite lower whole-body insulin sensitivity in black women, they exhibited a fatty acid pattern typically associated with higher insulin sensitivity in European populations. The results suggest that genetic factors may play a role in influencing fatty acid metabolism and insulin sensitivity among different ethnic groups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng, Jerome Baudry
Summary: SCD1 is a key metabolic protein involved in converting saturated fatty acids to monounsaturated fatty acids, with overactivity linked to diseases. Computational molecular dynamics study reveals interactions between SCD1, substrates, and products, providing insights for drug discovery.
Article
Immunology
Elien Grajchen, Melanie Loix, Paulien Baeten, Beatriz F. Corte-Real, Ibrahim Hamad, Sam Vanherle, Mansour Haidar, Jonas Dehairs, Jelle Y. Broos, James M. Ntambi, Robert Zimmermann, Rolf Breinbauer, Piet Stinissen, Niels Hellings, Sanne G. S. Verberk, Gijs Kooij, Martin Giera, Johannes V. Swinnen, Bieke Broux, Markus Kleinewietfeld, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Summary: The imbalance between pathogenic and protective T cell subsets is a key feature of autoimmune disorders such as multiple sclerosis (MS). The molecular mechanisms underlying the impact of fatty acid metabolism on T cell physiology and autoimmunity are poorly understood. The study reveals that fatty acid desaturation by SCD1 acts as an endogenous brake on regulatory T-cell differentiation and enhances autoimmunity, suggesting potential therapeutic strategies for autoimmune disorders such as MS.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Neurosciences
Daniel F. Tardiff, Matthew Lucas, Iwona Wrona, Belle Chang, Chee Yeun Chung, Bertrand Le Bourdonnec, Kenneth J. Rhodes, Robert H. Scannevin
Summary: Stearoyl-CoA desaturase (SCD) is a potential therapeutic target for Parkinson's and related neurodegenerative diseases. YTX-7739, a SCD inhibitor, effectively inhibits SCD in the brain and produces well-tolerated pharmacodynamic responses. It modulates the toxicity of α-synuclein by altering the ratio of fatty acids.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Maga Sanchez, Zeynep Dereli, Nermin Kahraman, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel McGrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B. Mills, Anil Korkut
Summary: This study suggests that targeting MCL1 and BET may have therapeutic potential for the treatment of basal-like breast cancers. BET inhibition induces an adaptive response leading to the evasion of apoptosis in breast cancer cells driven by MCL1 protein. The mechanism involves upregulation of lipid synthesis enzymes, which affects cell motility and membrane fluidity, as well as the activation of HER2/EGFR signaling. MCL1 copy-number alterations are associated with the effectiveness of BET and MCL1 co-targeting.
Article
Cell Biology
Chanchal Thomas Mannully, Reut Bruck-Haimson, Anish Zacharia, Paul Orih, Alaa Shehadeh, Daniel Saidemberg, Natalya M. Kogan, Sivan Alfandary, Raphael Serruya, Arie Dagan, Isabelle Petit, Arieh Moussaieff
Summary: Stem cell self-renewal and differentiation are regulated by metabolism, specifically lipid desaturation. Inhibiting specific metabolic enzymes can maintain stem cell characteristics and reduce cell apoptosis. Monounsaturated fatty acids are beneficial for stem cells but detrimental to trophoblast cells.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Gaetan Ravaut, Alexandre Legiot, Karl-F. Bergeron, Catherine Mounier
Summary: This article discusses the link between obesity and chronic inflammation, highlighting the impact of different fatty acid classes on inflammation in a metabolic context. Research suggests that MUFAs play a crucial role in modulating SFA-induced chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Anna Pacwa, Joanna Machowicz, Alicja Wojtyniak, Marita Pietrucha-Dutczak, Elisa Toropainen, Ali Koskela, Ewa Mrukwa-Kominek, Joanna Lewin-Kowalik, Adrian Smedowski
Summary: The study evaluated the effect of SCD1 inhibitor MF-438 on the differentiation of monocytes exposed to eye drop detergents. The results showed a strong correlation between SCD1 concentration and macrophage count in the culture.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yueqing Xue, Liangyu Lin, Qing Li, Keli Liu, Mingyuan Hu, Jiayin Ye, Jianchang Cao, Jingjie Zhai, Fanjun Zheng, Yu Wang, Tao Zhang, Liming Du, Cheng Gao, Guan Wang, Xuefeng Wang, Jun Qin, Xinhua Liao, Xiangyin Kong, Lydia Sorokin, Yufang Shi, Ying Wang
Summary: The role of fatty acid desaturation catabolized by SCD1 in regulating hair follicle stem cells and hair growth has been discovered. The absence of SCD1 leads to abnormal hair growth, affecting the appearance and quality of hair.
