Article
Chemistry, Multidisciplinary
Gernot F. Grabner, Nikolaus Guttenberger, Nicole Mayer, Anna K. Migglautsch-Sulzer, Christian Lembacher-Fadum, Nermeen Fawzy, Dominik Bulfon, Peter Hofer, Thomas Zuellig, Lennart Hartig, Natalia Kulminskaya, Gabriel Chalhoub, Margarita Schratter, Franz P. W. Radner, Karina Preiss-Landl, Sarah Masser, Achim Lass, Rudolf Zechner, Karl Gruber, Monika Oberer, Rolf Breinbauer, Robert Zimmermann
Summary: This study reports the development and biological characterization of the first small-molecule inhibitor of human ATGL. This inhibitor selectively inactivates ATGL in humans and nonhuman primates, providing a potential therapeutic option for lipotoxicity-driven disorders.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Marek Wilhelm, Lenka Rossmeislova, Michaela Siklova
Summary: This article reviews the characteristics of lipogenic and lipolytic enzymes and the methods available for measuring their activity. It evaluates the applicability of these methods to different biological samples and discusses the advantages and disadvantages of these methods in vivo, ex vivo, and in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Xiufei Cao, Wei Fang, Jiamin Li, Wencong Lai, Kangsen Mai, Qinghui Ai
Summary: This study reveals the involvement of antisense lncRNA LTCONS_00091578 and atgl in hepatic lipolysis in rainbow trout. The function of lncRNA in fish lipid metabolism needs further investigation.
Article
Biochemistry & Molecular Biology
Satoru Mukai, Akiko Mizokami, Takahito Otani, Tomomi Sano, Miho Matsuda, Sakura Chishaki, Jing Gao, Tomoyo Kawakubo-Yasukochi, Ronghao Tang, Takashi Kanematsu, Hiroshi Takeuchi, Eijiro Jimi, Masato Hirata
Summary: GPRC6A regulates various physiological processes in response to its interaction with multiple ligands and its constitutive activation in adipocytes plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Supreet Kaur, Christopher Auger, Dalia Barayan, Priyal Shah, Anna Matveev, Carly M. Knuth, Thurl E. Harris, Marc G. Jeschke
Summary: Hypermetabolism following severe burn injuries can lead to adipocyte dysfunction and other adverse consequences, with adipose triglyceride lipase (ATGL) playing a crucial role in regulating these processes. Targeting ATGL may reduce adipose tissue changes and improve patient outcomes, as demonstrated by selective ATGL inhibitor studies.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sander Kersten
Summary: Fasting and starvation have been significant environmental factors that have shaped human energy metabolism. Humans adapt to fasting through time-dependent changes in energy metabolism, including the breakdown of liver glycogen, muscle protein, and fat stores. This paper provides an overview of the effects of fasting on adipose tissue metabolism, including the inhibition of lipoprotein lipase activity and activation of adipose triglyceride lipase.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Oncology
Julie Cremer, Laura Brohee, Laura Dupont, Camille Lefevre, Raphael Peiffer, Alicia M. Saarinen, Olivier Peulen, Laure Bindels, Jun Liu, Alain Colige, Christophe F. Deroanne
Summary: Bidirectional interactions between cancer cells and adipocytes in the microenvironment play a critical role in tumor progression. Acidification of the extracellular medium induced by cancer cells promotes preadipocyte lipolysis, which affects the phenotype of cancer cells and their response to chemotherapy. G0S2 is identified as the main regulator of cancer-induced lipolysis, and its adipocyte-specific overexpression inhibits mammary tumor growth and lung metastasis.
Article
Biochemistry & Molecular Biology
Tianjiao Li, Wei Guo, Zhanxiang Zhou
Summary: Understanding the regulation of ATGL in the liver is crucial for understanding lipid and glucose homeostasis and developing targeted therapies for hepatic metabolic disorders.
Article
Biochemistry & Molecular Biology
Rahim Zareie, Emad Yuzbashian, Hamed Rahimi, Golaleh Asghari, Maryam Zarkesh, Mehdi Hedayati, Abolghassem Djazayery, Ariyo Movahedi, Parvin Mirmiran, Alireza Khalaj
Summary: In non-obese adults, gene expressions of ATGL and HSL in SAT were associated with dietary fat quantity and composition, while no associations were observed in obese individuals and non-obese individuals' VAT.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Article
Nutrition & Dietetics
Zhizheng Fang, Lu Wei, Yanping Lv, Tongsheng Wang, Hamizah Shahirah Hamezah, Rongchun Han, Xiaohui Tong
Summary: This study investigates the impact of Phillyrin on obesity-related metabolic dysfunctions. It was found that Phillyrin reduces circulating level of glycerol, hepatic steatosis, and improves insulin sensitivity in obese mice. Phillyrin also attenuates obesity-related inflammation and IL-6 production in adipose tissue. Furthermore, Phillyrin inhibits IL-6-initiated basal lipolysis and expression of adipose triglyceride lipase (ATGL) in adipose tissue. These findings suggest that Phillyrin can be a potential candidate in the treatment of obesity-associated complications.
FRONTIERS IN NUTRITION
(2022)
Editorial Material
Endocrinology & Metabolism
Melissa A. Linden, Susan J. Burke, Humza A. Pirzadah, Tai-Yu Huang, Heidi M. Batdorf, Walid K. Mohammed, Katarina A. Jones, Sujoy Ghosh, Shawn R. Campagna, J. Jason Collier, Robert C. Noland
Summary: Glucocorticoid therapy can cause iatrogenic diabetes, and activating lipolysis plays a crucial role in its development. Inhibiting lipolysis can reduce glucocorticoid-induced obesity and hyperglycemia. The role of lipolysis differs between skeletal muscle and liver.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Rajakumar Selvaraj, Sarah Zehnder, Russell Watts, Jihong Lian, Chinmayee Das, Randal Nelson, Richard Lehner
Summary: Two distinct diacylglycerol acyltransferases (DGAT1 and DGAT2) catalyze the final step of TG synthesis in hepatocytes. TG is either stored in cytosolic LDs or assembled into VLDLs in the ER. DGAT1-made TG is stored in smaller LDs while DGAT2-made TG is stored in larger LDs. ATGL targets DGAT1-generated LDs and the fatty acids released from these LDs are preferentially used for oxidation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Endocrinology & Metabolism
Yusuke Nakatsu, Takeshi Yamamotoya, Mizuki Okumura, Tetsuhiro Ishii, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Shunya Aoyama, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Tomoichiro Asano
Summary: Deleting the Pin1 gene in epiWAT promotes lipolysis and increases ATGL protein expression. Pin1 directly associates with ATGL, enhancing its degradation through the ubiquitin proteasome system. AdipoPin1 KO mice under a high fat diet exhibit higher lipolytic activity and improved glucose metabolism.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Wen-Jun Shen, Chris Still II, Lina Han, Pinglin Yang, Jia Chen, Michael Wosczyna, Benjamin Jean Rene Salmon, Kristy C. Perez, Jingtao Li, Pedro L. Cuevas, Bo Liu, Salman Azhar, Jill Helms, Lei S. Qi, Fredric B. Kraemer
Summary: There is an inverse relationship between the differentiation of MSCs along adipocyte or osteoblast lineages mediated by PPAR gamma and Runx2. HSL knockout in mice improved fracture repair and enhanced MSC differentiation and recruitment, while inhibiting HSL. This study highlights the potential role of HSL in bone injury repair and the importance of pre-osteoclasts and osteoclasts.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Cell Biology
Haofan Yin, Wentao Li, Laiming Mo, Shaotuan Deng, Weijia Lin, Caiqi Ma, Zhaofan Luo, Chuanghua Luo, Honghai Hong
Summary: Elevated levels of adipose triglyceride lipase (ATGL) in colorectal cancer patients are associated with advanced clinical stages and poor overall survival. ATGL promotes cell proliferation and inhibits apoptosis in CRC cells. Mechanistically, ATGL enhances the carcinogenic function of CRC cells by promoting lipid metabolism and CoA biosynthesis pathway. This study highlights ATGL as a novel oncogene in CRC with potential as a prognostic factor and therapeutic target.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Food Science & Technology
Liyi Wang, Ziye Xu, Defeng Ling, Jie Li, Yizhen Wang, Tizhong Shan
Summary: This article summarizes and discusses the roles of various dietary factors in regulating skeletal muscle development and function, and reviews their potential regulatory molecular mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Cheng Wang, Siyu Wei, Nana Chen, Yun Xiang, Yizhen Wang, Mingliang Jin
Summary: This study investigated the gut microbiota characteristics in 120 pigs of different breeds, growth periods, and genders, revealing that gut microbiota plays important roles in nutrition, metabolism, and immunity. The top 10 most abundant genera accounted for 66.53% of the microbiota, and 28 common species were identified. The explanatory effects of influencing factors suggested that growth period was the greatest contributor to the gut microbiota in pigs.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Cheng Wang, Siyu Wei, Bojing Liu, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang
Summary: Research has found that a maternal fermented diet can improve the performance of sows and piglets, accelerate the maturation of neonatal gut microbiota, and reduce susceptibility to colonic inflammation in offspring. Milk L-glutamine and gut Lactobacillus were identified as important factors in the fermented diet, which can modulate the gut microbiota and alleviate inflammation.
Article
Nutrition & Dietetics
Cheng Wang, Siyu Wei, Mingliang Jin, Bojing Liu, Min Yue, Yizhen Wang
Summary: The present study investigated the dynamics of microbiota and metabolites during solid-state fermentation of plant-based food using two-stage fermentation. It revealed the changes in predominant bacteria and metabolic pathways at different fermentation stages, with phenylalanine metabolism identified as the most important pathway. The correlations between microbiota and metabolites were also analyzed, showing significant associations between specific bacteria and amino acid metabolism.
FRONTIERS IN NUTRITION
(2022)
Article
Veterinary Sciences
Zipeng Jiang, Weifa Su, Chaoyue Wen, Wentao Li, Yu Zhang, Tao Gong, Shuai Du, Xinxia Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang
Summary: Clostridium perfringens is a main pathogen that can cause various diseases in humans and animals. This study aimed to build a mouse model infected with porcine C. perfringens and investigated its effects on growth performance, immune status, and intestinal integrity in mice. The results showed that high dose of C. perfringens caused a decline in growth performance, severe damage to intestinal structure, and increased inflammation in mice.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Weike Shaoyong, Yalin Liu, Bocheng Xu, Bo Pan, Xinuer Xianmi, Yizhen Wang, Mingliang Jin
Summary: This study found that exposure to BDE-47 can cause ovarian lipid deposition and hormone disruption accompanied by oxidative stress and downregulation of hormone biosynthesis-related proteins. Using a cellular model, it was shown that BDE-47 inhibits ovarian hormone secretion by interfering with specific pathways and inducing endoplasmic reticulum stress, mitochondrial abnormalities, and lipotoxicity. The findings suggest potential health risks of BDE-47 pollution areas to women, particularly affecting their ovarian hormone secretion.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nutrition & Dietetics
Jie Li, Shu Zhang, Xin Gu, Jintang Xie, Xiaodong Zhu, Yizhen Wang, Tizhong Shan
Summary: This study aimed to investigate the effects of different dietary levels of alfalfa on carcass traits, meat quality, amino acid and fatty acid composition, and the intestinal microbiota of Heigai pigs. The results showed that adding 30% alfalfa meal improved meat quality and changed the intestinal microflora composition without affecting the growth performance of Heigai pigs.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Xin Gu, Liyi Wang, Shiqi Liu, Tizhong Shan
Summary: Skeletal muscle is crucial in human biological activities and energy homeostasis, as well as meat production and quality in animals. Adipose tissue, particularly white and brown adipose tissue, acts not only as an energy reserve but also as an endocrine organ that secretes signaling molecules known as adipokines and lipokines. This review highlights the secretory role of adipose tissues and the regulatory effects of adipokines and lipokines on skeletal muscle development and homeostasis. It also suggests the potential use of these molecules as drug candidates for treating muscle dysfunction and metabolic diseases, as well as their role as promising nutrients for improving animal production.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Geriatrics & Gerontology
Wenjing You, Shiqi Liu, Jianfei Ji, Defeng Ling, Yuang Tu, Yanbing Zhou, Wentao Chen, Teresa G. Valencak, Yizhen Wang, Tizhong Shan
Summary: The study identifies GADD45A as a critical regulator of muscle repair and fat infiltration and suggests that EGCG may be a potential strategy to combat fat infiltration and its associated muscle dysfunction.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Editorial Material
Physiology
Zhihao Jia, Tizhong Shan
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Wentao Chen, Ziye Xu, Wenjing You, Yanbing Zhou, Liyi Wang, Yuqin Huang, Tizhong Shan
Summary: This study investigated the effects of acute cold exposure on lipid metabolism and transcriptomic changes in mouse skeletal muscle. The results showed that cold exposure led to increased intramuscular fat deposition, altered lipid composition, and upregulated genes involved in lipolysis and fatty acid biosynthesis. Cold-mediated mitophagy may play a critical role in modulating lipid metabolism in skeletal muscle, which is regulated by HIF-1 alpha signaling.
Article
Food Science & Technology
Liyi Wang, Xueyan Zhao, Shiqi Liu, Wenjing You, Yuqin Huang, Yanbing Zhou, Wentao Chen, Shu Zhang, Jiying Wang, Qiankun Zheng, Yizhen Wang, Tizhong Shan
Summary: This study investigated the cellular and transcriptional mechanisms underlying lipid deposition in highly-marbled pork using single-nucleus RNA sequencing and bulk RNA sequencing. The results revealed that the high marbled group had higher intramuscular fat (IMF) contents and lower drip loss compared to the low marbled group. Single-nucleus RNA sequencing showed a higher percentage of adipocytes in the high marbled group. Additionally, bulk RNA sequencing identified different genes involved in lipid metabolism and fatty acid elongation. The findings provide new insights into the cellular and molecular signatures of marbling formation in pork.
NPJ SCIENCE OF FOOD
(2023)
Article
Food Science & Technology
Shiqi Liu, Yuang Tu, Jiabao Sun, Peiran Cai, Yanbing Zhou, Yuqin Huang, Shu Zhang, Wentao Chen, Liyi Wang, Man Du, Wenjing You, Tenghao Wang, Yizhen Wang, Zeqing Lu, Tizhong Shan
Summary: This study aimed to investigate the effects of fermented mixed feed (FMF) supplementation on the intestinal microbial community, metabolites, and flavor compounds in pork. The results showed that FMF altered the profiles of microbes and metabolites in the colon. In addition, FMF supplementation significantly increased the concentrations of volatile flavor compounds and IMP, which contributed to improving pork flavor and umami.
Article
Agriculture, Dairy & Animal Science
Wuzhou Yi, Qixin Huang, Yizhen Wang, Tizhong Shan
Summary: Pork is a main source of meat consumption and its nutritional value is important for human health. The fat deposition and composition of pork affect sensory quality and nutritional quality. The lipids in pork include triglycerides, cholesterol, and phospholipids.
Article
Agriculture, Dairy & Animal Science
Shu Zhang, Yang Ren, Yuqin Huang, Yingchun Wang, Han Dang, Tizhong Shan
Summary: Pet obesity is a growing problem that negatively affects pet health. This study evaluated the effects of different carbohydrate sources on cat digestion, blood glucose response, serum biochemical immune index, and gut microbiota. The results showed that cat food with cassava and sweet potato as the main carbohydrate sources had a better effect on controlling blood glucose and blood lipids and improving the gut microbiota of pet cats.
JOURNAL OF ANIMAL SCIENCE
(2023)
