期刊
ANGIOLOGY
卷 66, 期 7, 页码 644-651出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319714546738
关键词
estimated glomerular filtration rate; no-reflow phenomenon; acute myocardial infarction; primary percutaneous coronary intervention
We investigated whether admission estimated glomerular filtration rate (eGFR) values are associated with no-reflow phenomenon in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Patients (n = 673; 59 +/- 13 years; 77.1% men) were stratified into 3 groups according to eGFR at admission: normal renal function (eGFR 90 mL/min/1.73 m(2)), mild renal impairment (eGFR 60-89 mL/min/1.73 m(2)), and moderate renal impairment (eGFR 30-59 mL/min/1.73 m(2)). No-reflow phenomenon was defined as thrombolysis in myocardial infarction flow grade <3 after pPCI. The rate of no-reflow gradually increased from the normal renal function group to the moderate impaired renal function group (P < .001). Multivariate analysis showed that eGFR (odds ratio [OR] 0.942, P < .001), Killip 2 class (OR 3.968, P = .008), left ventricular ejection fraction (OR 0.959, P = .034), and early patency of infarct vessel (OR 0.186, P < .001) were independent predictors of no-reflow phenomenon. Mild to moderate renal impairment at admission is independently associated with no-reflow phenomenon after pPCI.
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