Article
Medicine, General & Internal
Kei Nakajima, Manami Igata, Ryoko Higuchi, Kotone Tanaka, Kaori Mizusawa, Teiji Nakamura
Summary: Both low and extremely high HDL-C concentrations are associated with high blood pressure. The former association might be dependent on excess fat mass concomitant with low HDL-C, whereas the latter association may be largely dependent on frequent alcohol consumption.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Hayato Tada, Hirofumi Okada, Atsushi Nohara, Ryuji Toh, Amane Harada, Katsuhiro Murakami, Takuya Iino, Manabu Nagao, Tatsuro Ishida, Ken-ichi Hirata, Masayuki Takamura, Masa-aki Kawashiri
Summary: The function of high-density lipoprotein (HDL) is more important than the HDL cholesterol (HDL-C) level in predicting the risk of coronary artery disease (CAD). A study on patients with familial hypercholesterolemia (FH) found that serum cholesterol uptake capacity (CUC) levels were significantly lower in patients with CAD compared to those without CAD. The study also showed that CUC levels were negatively correlated with the carotid plaque score and were independently associated with CAD, while HDL-C was not.
CIRCULATION JOURNAL
(2023)
Article
Medicine, General & Internal
Siwen Zang, Yanlei Chen, Haike Guo, Min Zhang, Guanrong Zhang, Lixin Zhang, Liang Zhang, Qingyang Liu, Jin Zeng, Chun-Han Lo, Ying Cui, Qianli Meng
Summary: This study investigated the relationship between serum lipids and pterygium in a large-scale rural population in Southern China aged 40 years or older. The study found that increased levels of high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were positively associated with the risk of pterygium. This association was stronger in participants aged 40-49 years and those with a normal body mass index (BMI).
Article
Endocrinology & Metabolism
Yuxiu Wang, Jiaoyue Zhang, Huiqing Li, Wen Kong, Juan Zheng, Yan Li, Qi Wei, Qin Li, Li Yang, Ying Xu, Li Li, Hanyu Wang, Hui Sun, Wenfang Xia, Geng Liu, Xueyu Zhong, Kangli Qiu, Han Wang, Hua Liu, Xiaoli Song, Si Xiong, Yumei Liu, Zhenhai Cui, Lulu Chen, Tianshu Zeng
Summary: Novel hematological parameters derived from high-density lipoprotein-cholesterol (HDL-C) were rarely studied as indicators for the risk of poor outcomes in patients with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. Lower HDL-C concentrations and higher neutrophil to HDL-C ratio (NHR) at admission were significantly associated with a poor prognosis in COVID-19 patients and diabetes subgroup.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Andreina Arias, Alonso Quiroz, Nicolas Santander, Eugenia Morselli, Dolores Busso
Summary: Cholesterol plays a crucial role in maintaining the proper functioning of animal cells. Abnormal metabolism of high-density lipoproteins (HDL) may affect female fertility. HDL in follicular fluid (FF) can uptake excess unesterified cholesterol (UC) from cumulus cells, and the accumulation of UC may impair the developmental capacity of the egg. Cholesterol accumulation can affect cell viability and the activity of membrane proteins, potentially through the activation of calcium channels and dysregulation of cell death/survival signaling pathways. Evaluating cholesterol and lipid levels is important for the diagnosis and treatment of infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medical Laboratory Technology
Yang Geng, Yan Liu, Yan Chen, Zhenwen Zhang, Liping Wang, Xiaobo Li, Binlan Xia, Bin Song, Hengzhong Zhang
Summary: In the Chinese population with a high risk of stroke, a higher LDLc/HDLc ratio was significantly associated with the presence of carotid plaques.
CLINICAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Hee-Won Noh, Yena Jeon, Ji-Hye Kim, Ga-Young Lee, Soo-Jee Jeon, Kyu-Yeun Kim, Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Summary: This study found that the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) is associated with mortality in peritoneal dialysis patients. Patients with higher TC/HDL-C had higher body mass index, diabetes prevalence, and serum albumin level. However, individual levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were not associated with mortality.
Article
Cell Biology
Jiasi Chen, Zhong Zhong, Jianbo Li, Jianwen Yu, Yi Yu, Bin Li, Haiping Mao, Zhijian Li
Summary: The study aimed to evaluate the association between MPV/PC and mortality in peritoneal dialysis (PD) patients. The results showed that low MPV/PC level was an independent risk factor for all-cause and cardiovascular mortality in PD patients aged less than 60 years.
MEDIATORS OF INFLAMMATION
(2022)
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Gabriele Mazzuferi, Tiziana Bacchetti, Md Obaidul Islam, Gianna Ferretti
Summary: Breast cancer is a major cause of female mortality, with recent studies focusing on the role of lipoproteins, cholesterol metabolism alterations, and oxidative stress in the molecular mechanism of the disease. Low levels of HDL-C have been suggested as a risk factor for breast cancer, but conflicting results have been reported. Alterations in enzyme activity associated with HDL and higher levels of lipid peroxidation markers in breast cancer patients suggest dysfunctional HDL may play a role in the disease.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Chemistry, Applied
Yanyan Wang, Hai Gao, Xinya Huang, Zhaoan Chen, Pengyu Kang, Yunyi Zhou, Danhua Qin, Wenli Zhang, Jianping Liu
Summary: This study designed a sequential-targeting nanoplatform for the treatment of atherosclerosis. The nanoplatform can release specific drugs in atherosclerotic macrophages to achieve therapeutic effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Yuan Kong, Yong-Jia Yi, Xiao-Qing Liu, Pan Yu, Lin-Guo Zhao, Dong-Dong Li
Summary: In this study, a series of berberine analogs were synthesized and evaluated for their lipid-lowering activities. Compound 1m was found to exhibit potent cholesterol inhibitory activity and had significant effects on LDLC and HDLC levels. The results suggest that 1m has the potential to be a new lipid-lowering agent.
BIOORGANIC CHEMISTRY
(2022)
Article
Medicine, General & Internal
Rahul Aggarwal, Deepak L. Bhatt, Fatima Rodriguez, Robert W. Yeh, Rishi K. Wadhera
Summary: Lipid concentrations improved among US adults over the past decade, while rates of lipid control did not significantly change among adults receiving statin therapy. There were improvements in lipid control among certain racial and ethnic groups, but disparities remained between genders and races.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Hasan Aydin Bas, Fatih Aksoy, Ali Bagci, Ercan Varol, Ahmet Altinbas
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2020)
Article
Medicine, General & Internal
Fatih Aksoy, Dincer Uysal, Erdogan Ibrisim
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2020)
Article
Medicine, General & Internal
Fatih Aksoy, Dincer Uysal, Erdogan Ibrisim
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2020)
Article
Cardiac & Cardiovascular Systems
Fatih Aksoy, Hasan Aydin Bas, Ali Bagci, Hasan Basri Savas
Summary: The study found that increased oxidative stress and inflammation parameters were associated with the development of CIN in patients with STEMI. Other independent predictors of CIN were contrast media volume/eGFR ratio, initial glucose level, UA, and hs-CRP.
REVISTA PORTUGUESA DE CARDIOLOGIA
(2021)
Article
Pharmacology & Pharmacy
Ali Bagci, Fatih Aksoy
Summary: The study revealed that the frontal plane QRS-T angle was significantly higher in patients with prehypertension (PHT) compared to normotensive individuals, and was similar between PHT and hypertension (HT) groups. The angle was found to be significantly correlated with various physiological parameters and could serve as predictors for higher systolic blood pressure, pulse pressure, etc.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mehmet Artug Onal, Ozlem Fentoglu, Fatih Aksoy, Mustafa Calapoglu, Ercan Varol, Hikmet Orhan
Summary: The study found that patients with cardiovascular disease had higher clinical periodontal parameters, lower salivary levels of protectins (PD), and higher levels of maresins (MaR). These results suggest that PDs and MaRs may play a role in the pathogenesis associated with cardiometabolic and periodontal status.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Ali Bagci, Fatih Aksoy
Summary: The study demonstrates that the systemic immune-inflammation index (SII) can be used as an independent predictor of new onset atrial fibrillation (NOAF) following ST segment elevation myocardial infarction (STEMI). Compared to high-sensitive C-reactive protein, SII has a similar predictive capacity for NOAF detection.
BIOMARKERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ali Bagci, Fatih Aksoy, Hasan Aydin Bas, Ismail Barkin Isik, Fatih Akkaya, Hikmet Orhan
Summary: The study revealed that the f(QRS-T) angle was significantly widened in patients with exaggerated MBPS, indicating a severe ventricular repolarization disorder in these patients. Both MBPS and T peak-end were identified as independent predictors of the f(QRS-T) angle.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Medicine, General & Internal
Fatih Aksoy, Dincer Uysal
Summary: The study demonstrated that CHA(2)DS(2)-VASc and anticoagulation, as well as risk factors in atrial fibrillation risk scores, easily predicted one-year mortality in patients with abdominal aortic aneurys situat, showing their clinical utility in assessing patient outcomes.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Letter
Cardiac & Cardiovascular Systems
Fatih Aksoy, Serdar Guler
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Dincer Uysal, Fatih Aksoy, Erdogan Ibrisim
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2020)
Article
Emergency Medicine
Cihan Bedel, Mustafa Korkut, Fatih Aksoy, Gorkem Kus
ARCHIVES OF ACADEMIC EMERGENCY MEDICINE
(2020)
