期刊
ANGIOLOGY
卷 65, 期 7, 页码 614-619出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319713491309
关键词
essential hypertension; angiotensinogen; A-20C; A-6G; C3889T; C4072T; Northern Han Chinese population
资金
- National Basic Research Program [2006BAI19B07]
- National Key Laboratory Specific Fund [2060204]
Gene polymorphisms of the renin-angiotensin system are involved in the pathophysiology of hypertension. We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population. There were significant differences in the distribution of genotypes and allele frequencies at C4072T between the patients and the controls (both P < .01); patients with CC genotype had a higher risk of hypertension (odds ratio = 1.7, 95% confidence interval 1.4-2.1). The distribution of genotypes at A-6G was significantly different between patients and controls (P < .05). No other significant differences in genotypes or frequencies were observed. No association was observed between the haplotypes of AGT and hypertension. The AGT-6A and 4072C alleles are associated with susceptibility to hypertension in this population.
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