Article
Nutrition & Dietetics
Jia-Ning Syu, Hung-Yu Lin, Tun Yu Huang, Der-Yen Lee, En-Pei Isabel Chiang, Feng-Yao Tang
Summary: In this study, it was found that trimethylamine-N-oxide (TMAO) has detrimental effects on the neovascularization of human endothelial progenitor cells (hEPCs), while docosahexaenoic acid (DHA) could alleviate these effects. The mechanism involves upregulation of miR-221 level, inactivation of Akt/eNOS and MAPK/ERK signaling cascades, suppression of ?-GCS protein, and decreased levels of glutathione (GSH) and GSH/GSSG ratio. DHA reverses these effects by suppressing miR-221 level, activating Akt/eNOS and MAPK/ERK signaling cascades, increasing expression of ?-GCS protein, and increasing cellular GSH level and GSH/GSSG ratio in hEPCs.
Article
Medicine, Research & Experimental
Keisuke Nakagawa, Mayuko Itoya, Nao Takemoto, Yuika Matsuura, Masashi Tawa, Yasuo Matsumura, Mamoru Ohkita
Summary: This study showed that IS increases O-2(-) production in vascular tissues, attenuating ACh- and SNP-induced vasorelaxation via potential NO inactivation. Additionally, IS-promoted O-2(-) production in the presence of vascular endothelium is likely through binding to AhR and activation of NADPH oxidase.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Biology
Bi-Ang Kang, Hua-Ming Li, Ya-Ting Chen, Meng-Jie Deng, Yan Li, Yue-Ming Peng, Jian-Jun Gao, Zhi-Wei Mo, Jia-Guo Zhou, Zhi-Jun Ou, Jing-Song Ou
Summary: This study demonstrates that nHDL stimulates autophagy and promotes angiogenesis by suppressing miR-181a-5p and increasing eNOS expression, while dHDL inhibits autophagy and eNOS expression by increasing miR-181a-5p expression, leading to impaired angiogenesis.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Food Science & Technology
Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. Ward
Summary: Endothelial dysfunction may lead to atherosclerosis, while dietary nitrate/nitrite shows significant benefits on cardiovascular homeostasis. Research suggests that nitrate/nitrite may enhance eNOS activation by stimulating AMPK signaling pathway, potentially contributing to vascular protective effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Multidisciplinary
Tian-tian Liu, Huan-huan Xu, Ze-juan Liu, He-ping Zhang, Hai-tao Zhou, Zhi-xiang Zhu, Zhi-qiang Wang, Jing-yi Xue, Qiang Li, Yi Ma, Hong-jie You, Da-li Luo
Summary: Endothelial dysfunction is a central characteristic of cardiovascular pathogenesis in diabetes mellitus, characterized by impaired eNOS and NO bioavailability. This study identified the role of CaM in the dysfunction of eNOS in diabetes. Downregulated CaM expression was found to be responsible for endothelial injury and impaired angiogenesis in diabetes. The findings provide a novel mechanism and target for protecting against diabetic endothelial injury.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Peripheral Vascular Disease
Sarah M. McCann Haworth, Zhengbing Zhuge, Carina Nihlen, Matilda Fornell Von Rosen, Eddie Weitzberg, Jon O. Lundberg, Rafael T. Krmar, Josefine Nasiell, Mattias Carlstrom
Summary: This study reveals that in patients with pre-eclampsia, red blood cells exhibit increased arginase activity and expression, which are correlated with disease severity. Red blood cells can mediate endothelial dysfunction in pre-eclampsia through arginase-dependent and oxidative stress-dependent mechanisms. Targeting red blood cell arginase may offer a novel treatment approach for pre-eclampsia.
JOURNAL OF HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Food Science & Technology
Wen-Hua Chen, Bei-Chia Guo, Chia-Hui Chen, Man-Chen Hsu, Chih-Hsien Wang, Tzong-Shyuan Lee
Summary: The study found that statins increase the bioavailability of nitric oxide (NO) by activating kinase and calcium-dependent pathways in endothelial cells (ECs), and this effect is mediated through the autophagy-urea cycle-L-arginine pathway. These findings have important implications for the understanding of statins' mechanisms of action in the treatment of cardiovascular diseases.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Thi Thuy Tien Vo, Yinshen Wee, Hsin-Chung Cheng, Ching-Zong Wu, Yuh-Lien Chen, Vo Phuoc Tuan, Ju-Fang Liu, Wei-Ning Lin, I-Ta Lee
Summary: This study investigated the anticancer effects and underlying mechanisms of surfactin on human oral squamous cell carcinoma (OSCC). The results showed that surfactin could induce apoptosis, autophagy, and cell cycle arrest through different signaling pathways. The study suggests that surfactin may serve as a multifaceted anticancer agent for OSCC.
Article
Clinical Neurology
Ling-Yu Yang, Yong-Ren Chen, Jing-Er Lee, Kuo-Wei Chen, Hui-Tzung Luh, Yi-Tzu Chen, Kuo-Chuan Wang, Sung-Tsang Hsieh
Summary: This study found that dental pulp stem cell conditioned medium (DPSC-CM) can improve microcirculation impairment caused by aneurysmal subarachnoid hemorrhage (SAH) and has anti-inflammatory effects. DPSC-CM treatment can reduce brain edema, improve brain function recovery, and decrease the expression of pro-inflammatory cytokines. In addition, DPSC-CM alleviates astrocyte swelling induced by hemolysate/SAH-patient cerebrospinal fluid (CSF) and promotes M2 microglia polarization through the IGF-1/AKT signaling pathway.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wei-Ching Fang, Hsing-Yu Chen, Shao-Chi Chu, Po-Hsi Wang, Chin-Chan Lee, I-Wen Wu, Chiao-Yin Sun, Heng-Jung Hsu, Chun-Yu Chen, Yung-Chang Chen, Vin-Cent Wu, Heng-Chih Pan
Summary: This study evaluated the predictive performance of biomarkers in determining the likelihood of developing rapid kidney function decline (RKFD) in a healthy population. It found that serum cystatin C level could predict the possibility of RKFD, and suggested that a low cystatin C level should be considered as a risk factor for RKFD in healthy subjects.
Article
Medicine, General & Internal
Chun-Fu Lai, Jung-Hua Liu, Li-Jung Tseng, Chun-Hao Tsao, Nai-Kuan Chou, Shuei-Liong Lin, Yung-Ming Chen, Vin-Cent Wu
Summary: This study used unsupervised consensus clustering to investigate the heterogeneity in dialysis-requiring sepsis-associated acute kidney injury (SA-AKI) patients. Three sub-phenotypes were identified based on 23 clinical variables, which exhibited distinct clinical manifestations at the initiation of renal replacement therapy. Among them, sub-phenotype 1, characterized by younger age, lower Charlson Comorbidity Index, higher baseline estimated glomerular filtration rate but higher severity of acute illness, had a higher risk of death and a lower probability of being free of dialysis compared to sub-phenotype 3.
ANNALS OF MEDICINE
(2023)
Letter
Endocrinology & Metabolism
Sheng-Yin Chen, Vin-cent Wu
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Hematology
Jia-Arng Lee, Mei-Hwa Lin, Chun-Min Kang, Ming-Kai Chuang, Chi Kwan Boris Fung, Shyh-Chyi Lo
Summary: The PLASMIC score is used to differentiate TTP from other types of thrombotic microangiopathy. However, previous validations showed non-significant differences in MCV and INR between TTP and non-TTP patients. In this study, the PLASMIC score was validated and modified by adjusting the criteria for MCV and INR.
JOURNAL OF CLINICAL APHERESIS
(2023)
Article
Medicine, General & Internal
Wen-Jie Liu, Wern-Cherng Cheng, Yun-Yuan Chen, Chun-Min Kang, Jen-Wei Chen, Ming-Chih Ho, Shyh-Chyi Lo
Summary: Perioperative fresh frozen plasma transfusion is associated with poorer short-term outcomes, including postoperative bacterial infection and extended length of stay, in hepatocellular carcinoma patients undergoing liver resection. Reducing perioperative fresh frozen plasma transfusions may improve postoperative outcomes.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Yu-Chieh Tsai, Yung-Ming Chen, Chiung-Jung Wen, Meng-Chen Wu, Yi-Chun Chou, Jen-Hau Chen, Kun-Pei Lin, Ding-Cheng Chan, Feng-Ping Lu
Summary: The 30-day hospital readmission rate is significantly related to advanced age, and the predictive ability of existing models for readmission risk in the oldest population is uncertain. In addition to multimorbidity, a history of falls and frailty are associated with higher readmission risk in older adults.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Zhi-Ye Yu, Tai-Shuan Lai, Shao-Yu Yang, Shih- Chen, Mei-Jun Lai, Chun-Min Kang, Yu-Tsung Huang, Yi-Ting Chen, Po-Ren Hsueh, Yung-Ming Chen, Shuei-Liong Lin
Summary: Patients on peritoneal dialysis (PD) had fewer adverse events after COVID-19 vaccination compared to volunteers. PD patients had lower antibody concentrations compared to volunteers, but the levels increased after the second dose of vaccination. The mRNA-1273 vaccine induced a higher antibody and T cell response than the ChAdOx1-S vaccine in PD patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Vin- Cent Wu, Chieh-Kai Chan, Jeff S. Chueh, Yung-Ming Chen, Yen- Hung Lin, Chin-Chen Chang, Po-Chih Lin, Shiu-Dong Chung, TAIPAI grp
Summary: A study found that targeted treatment with MRAs or adrenalectomy in patients with PA leads to a decline in estimated glomerular filtration rate. However, the changes in biomarkers of kidney tubule health are still unclear.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Yi-Chih Lin, Hsiao-Mei Tsao, Tai-Shuan Lai, Yi-Ting Chen, Yu-Hsiang Chou, Shuei-Liong Lin, Yung-Ming Chen, Kuan-Yu Hung, Yu-Kang Tu
Summary: The use of lipid-lowering drugs in patients with advanced chronic kidney disease and dyslipidemia can reduce the risk of end-stage kidney disease and major adverse cardiovascular events.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Ya-Yun Wang, Ying-Hung Lin, Vin-Cent Wu, Yu-Hua Lin, Chia-Yen Huang, Wei-Chi Ku, Chiao-Yin Sun
Summary: Oxidative stress is a major cause of male infertility, and the protein Klotho is involved in oxidative regulation and male fertility. This study shows that Klotho deficiency accelerates damage to sperm quality and spermatogenesis, and affects the expression of GST proteins which are important for antioxidant defense.
Article
Urology & Nephrology
Yu-Hsiang Chou, Tai-Shuan Lai, Yi-Chih Lin, Wen-Chih Chiang, Tzong-Shinn Chu, Shuei-Liong Lin, Yung-Ming Chen
Summary: Older adults with chronic kidney disease (CKD) may experience accelerated progression of the disease due to acute kidney injury (AKI), despite old age being considered a positive modifier of CKD. This study aimed to investigate this paradoxical interaction and identify age-specific predictors for end-stage kidney disease (ESKD). The results showed that older adults with CKD had a slower decline rate of estimated glomerular filtration rate (eGFR) but were more likely to develop ESKD following AKI episodes. Therefore, preventing AKI to prevent accelerated initiation of renal replacement therapy in elderly patients with pre-existing CKD is necessary.