Article
Oncology
Xitao Zhang, Tianlai Liu, Jinlin Huang, Jianping He
Summary: This study revealed that PICALM promotes CRC progression through the ERK/MAPK signaling pathway, highlighting its potential as a therapeutic target in clinical applications.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Liangyu Guo, Kangwen Xiao, Yuanlong Xie, Zhiqiang Yang, Jun Lei, Lin Cai
Summary: This study validated the effect of HSPB6 on osteosarcoma through experiments and found that HSPB6 overexpression can inhibit cell proliferation, increase apoptosis, reduce cell migration and invasion in osteosarcoma. These effects are mediated through the ERK signaling pathway.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yu Cai, Peiyong Chen, Hui Xu, Shanglai Li, Bingru Zhao, Yixuan Fan, Feng Wang, Yanli Zhang
Summary: In this study, it was found that EZH2 gene knockdown in sheep pituitary cells led to decreased cell proliferation, increased apoptosis, and reduced FSH secretion. These effects were mediated through the modulation of the AKT/ERK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chuntian Huang, Ruijuan Du, Xuechao Jia, Kangdong Liu, Yan Qiao, Qiong Wu, Ning Yao, Lu Yang, Liting Zhou, Xuejiao Liu, Pu Xiang, Mingxia Xin, Yan Wang, Xiaojie Chen, Dong Joon Kim, Zigang Dong, Xiang Li
Summary: The study revealed that CDK15 plays a pivotal role in colorectal cancer progression by phosphorylating PAK4 to promote tumor growth. The CDK15-PAK4 axis may serve as a novel therapeutic target for colorectal cancer.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Huiyuan Pang, Di Lei, Jinfa Huang, Yuping Guo, Cuifang Fan
Summary: Prostaglandins are involved in maternal recognition of pregnancy, implantation, and maintenance of gestation. Prostaglandin transporter (PGT), a potential carrier molecule of prostaglandins, may play a role in the pathogenesis of preeclampsia. Through various techniques, PGT was found to be upregulated in preeclamptic placental tissue and its expression pattern was confirmed through multiple databases. Further studies showed that PGT is located in trophoblast cells of the placenta and its forced expression promotes trophoblast proliferation through the activation of the Erk signaling pathway. In animal models of preeclampsia, PGT was also found to be upregulated. These findings provide new insights into the understanding of the pathogenesis of preeclampsia.
MOLECULAR AND CELLULAR PROBES
(2023)
Article
Cell Biology
Payam E. Farahani, Sandra B. Lemke, Elliot Dine, Giselle Uribe, Jared E. Toettcher, Celeste M. Nelson
Summary: The stiffness of the underlying substratum affects Erk signaling dynamics in mammary epithelial cells, soft microenvironments attenuate Erk signaling and alter the amount and spatial distribution of EGF binding at cell membranes. The mechanical microenvironment tunes Erk signaling dynamics via receptor-ligand interactions.
Article
Cell Biology
Yu He, Xixi Wang, Weiliang Lu, Dan Zhang, Lan Huang, Yang Luo, Li Xiong, Haocheng Li, Peng Zhang, Qiu Li, Shufang Liang
Summary: This study comprehensively explores the molecular mechanisms of PGK1 in the progression and sorafenib resistance of KIRC. The upregulation of PGK1 is associated with poor prognosis in KIRC patients. Furthermore, PGK1 promotes tumor growth and sorafenib resistance in KIRC through regulating glycolysis and the CXCR4/ERK signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Safdar, Aixin Liang, Shahid Ali Rajput, Nasir Abbas, Muhammad Zubair, Aftab Shaukat, Aziz ur Rehman, Huma Jamil, Yan Guo, Farman Ullah, Liguo Yang
Summary: The study revealed the expression of OXA and OX1R in different developmental stages of GCs, showing that OX1R knockdown upregulated apoptosis and triggered S-phase arrest in cell cycle progression. Silencing OX1R suppressed GCs proliferation and decreased the phosphorylation level of the AKT and ERK1/2 proteins, indicating involvement of the AKT/ERK1/2 pathway.
Article
Biochemistry & Molecular Biology
Yaping Meng, Tong Lv, Junfeng Zhang, Weimin Shen, Lifang Li, Yaqi Li, Xin Liu, Xing Lei, Xuguang Lin, Hanfang Xu, Anming Meng, Shunji Jia
Summary: This study reveals the involvement of the Efnb2-Ephb4-Rasa1 regulated Erk signaling axis in lymphatic valve development. The inhibition of Erk signaling during valve cell specification and the opposite roles of Erk signaling in lymphatic vessel development and lymphatic valve formation are demonstrated. The findings provide insights into the molecular mechanism of lymphatic valve formation and have implications for the treatment of lymphatic disorders.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Pharmacology & Pharmacy
Y-J Yang, S. Luo, Z-L Xu
Summary: MiR-490-5p was found to be lowly expressed in colon cancer patients. Overexpression of miR-490-5p inhibited the proliferation and promoted the apoptosis of colon cancer cells via down-regulating CDK1 both in vitro and in vivo.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hongwei Yang, Guanghui Liu, Hongchao Zhao, Xinhua Dong, Zhen Yang
Summary: Geraniol, a natural compound found in aromatic plants, exhibits anticancer effects by inducing ROS production and inhibiting mitochondrial membrane potential in gastric cancer cells. It also affects apoptosis-related protein expression and mitochondrial ROS production to exert its therapeutic properties against human stomach cancer.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Cell Biology
Hanlin Ma, Fang Han, Xiaohui Yan, Gonghua Qi, Yingwei Li, Rongrong Li, Shi Yan, Cunzhong Yuan, Kun Song, Beihua Kong
Summary: Cervical cancer is the fourth most common cancer in women globally, and the overexpression of PBK in cervical cancer tissues promotes proliferation, metastasis, and cisplatin resistance of cancer cells through the ERK/c-Myc signaling pathway. Inhibition of PBK with OTS514 shows promising results in suppressing tumor growth and enhancing chemosensitivity. Further studies on PBK as a molecular target for cervical cancer treatment are warranted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chengfei Zhang, Xiaoming Wang, Dan Fang, Ping Xu, Xiao Mo, Chao Hu, Alaa Abdelatty, Mei Wang, Haojun Xu, Qi Sun, Guoren Zhou, Junjun She, Jinglin Xia, Kam Man Hui, Hongping Xia
Summary: The study revealed that STK39 is highly overexpressed in clinical HCC tissues, induced by transcription factor SP1, and correlated with poor patient survival. Overexpression of STK39 promoted HCC cell proliferation, migration, and invasion, while depletion of STK39 attenuated growth and metastasis. Knockdown of STK39 induced HCC cell cycle arrest and apoptosis.
Article
Cell Biology
Zhiqin Fang, Yutong Wang, Bo Huang, Xiang Chen, Rundong Jiang, Mingzhu Yin
Summary: G9A, an important methyltransferase, is highly expressed in psoriasis. Inhibition of G9A can improve psoriatic dermatitis by regulating cell proliferation and apoptosis rather than inflammatory processes.
CELL DEATH & DISEASE
(2023)
Article
Pathology
Mu-En Lin, Theodore Chen, Elizabeth M. Leaf, Mei Y. Speer, Cecilia M. Giachelli
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Article
Clinical Neurology
Mary Catherine Wallingford, Jia Jun Chia, Elizabeth M. Leaf, Suhaib Borgeia, Nicholas W. Chavkin, Chenphop Sawangmake, Ken Marro, Timothy C. Cox, Mei Y. Speer, Cecilia M. Giachelli
Article
Cardiac & Cardiovascular Systems
Mu-En Lin, Theodore M. Chen, Mary C. Wallingford, Ngoc B. Nguyen, Shunsuke Yamada, Chenphop Sawangmake, Jaimei Zhang, Mei Y. Speer, Cecilia M. Giachelli
CARDIOVASCULAR RESEARCH
(2016)
Article
Urology & Nephrology
Neil J. Paloian, Elizabeth M. Leaf, Cecilia M. Giachelli
KIDNEY INTERNATIONAL
(2016)
Article
Reproductive Biology
Mary C. Wallingford, Hilary S. Gammill, Cecilia M. Giachelli
REPRODUCTIVE BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Melissa F. Jackson, Marta Scatena, Cecilia M. Giachelli
Article
Biochemistry & Molecular Biology
Shunsuke Yamada, Mary C. Wallingford, Suhaib Borgeia, Timothy C. Cox, Cecilia M. Giachelli
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Cardiac & Cardiovascular Systems
Marta Scatena, Melissa F. Jackson, Mei Y. Speer, Elizabeth M. Leaf, Mary C. Wallingford, Cecilia M. Giachelli
CARDIOVASCULAR PATHOLOGY
(2018)
Review
Cardiac & Cardiovascular Systems
Andrew L. Durham, Mei Y. Speer, Marta Scatena, Cecilia M. Giachelli, Catherine M. Shanahan
CARDIOVASCULAR RESEARCH
(2018)
Article
Urology & Nephrology
Shunsuke Yamada, Elizabeth M. Leaf, Jia Jun Chia, Timothy C. Cox, Mei Y. Speer, Cecilia M. Giachelli
KIDNEY INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Sampada Chande, Daniel Caballero, Bryan B. Ho, Jonathan Fetene, Juan Serna, Dominik Pesta, Ali Nasiri, Michael Jurczak, Nicholas W. Chavkin, Nati Hernando, Cecilia M. Giachelli, Carsten A. Wagner, Caroline Zeiss, Gerald Shulman, Clemens Bergwitz
SCIENTIFIC REPORTS
(2020)
Article
Physiology
Nicholas W. Chavkin, Elizabeth M. Leaf, Kadin E. Brooks, Mary C. Wallingford, Susan M. Lund, Cecilia M. Giachelli
Summary: SLC20A1 is crucial for vascular smooth muscle cell matrix mineralization and transdifferentiation induced by high phosphate levels. It activates ERK1/2 phosphorylation through RapGEF1 and a Rap1/B-Raf/Mek1/2 signaling pathway, which inhibits SM22 alpha gene expression in VSMCs.
JOURNAL OF VASCULAR RESEARCH
(2021)
Article
Endocrinology & Metabolism
Worakanya Buranaphatthana, Apichai Yavirach, Elizabeth M. Leaf, Marta Scatena, Hai Zhang, Jonathan Y. An, Cecilia M. Giachelli
Summary: Research has shown that in a tooth extraction-triggered MRONJ model, the use of engineered osteoclasts can prevent specific pathological features of MRONJ.
Article
Multidisciplinary Sciences
Medania Purwaningrum, Cecilia M. Giachelli, Thanaphum Osathanon, Sirirat Rattanapuchpong, Chenphop Sawangmake
Summary: Periodontal ligament stem cells (PDLSCs) play a significant role in regulating periodontal tissue and alveolar bone homeostasis. This study shows that the inflammatory mediator IL-6 can have beneficial effects on the osteogenic differentiation of human PDLSCs. IL-6 enhances osteogenic potential through the activation of Wnt pathways and may contribute to tissue regeneration.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Shunsuke Yamada, Cecilia M. Giachelli