期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 43, 页码 14255-14259出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201809992
关键词
carbon; microelectrodes; neurotransmitters; sensors; two-photon lithography
资金
- NIH [R01EB026497, R01MH085159]
- DOE Office of Science [CNMS 2017-076]
Implantable neural microsensors have significantly advanced neuroscience research, but the geometry of most probes is limited by the fabrication methods. Therefore, new methods are needed for batch-manufacturing with high reproducibility. Herein, a novel method is developed using two-photon nanolithography followed by pyrolysis for fabrication of free-standing microelectrodes with a carbon electroactive surface. 3D-printed spherical and conical electrodes were characterized with slow scan cyclic voltammetry (CV). With fast-scan CV, the electrodes showed low dopamine LODs of 11 +/- 1 nm (sphere) and 10 +/- 2 nm (cone), high sensitivity to multiple neurochemicals, and high reproducibility. Spherical microelectrodes were used to detect dopamine in a brain slice and invivo, demonstrating they are robust enough for tissue implantation. This work is the first demonstration of 3D-printing of free-standing carbon electrodes; and the method is promising for batch fabrication of customized, implantable neural sensors.
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