期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 41, 页码 13538-13541出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808196
关键词
fluorogenic probes; histological imaging; influenza virus; neuraminidase
资金
- NIH [AI114730]
- Kwang Hua Educational foundation
- Canadian Institutes for Health Research
- Canadian Glycoscience Network GlycoNet
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI114730] Funding Source: NIH RePORTER
Reagents to visualize and localize neuraminidase activity would be valuable probes to study the role of neuraminidases in normal cellular processes as well as during viral infections or cancer development. Herein, a new class of neuraminidase-imaging probes that function as proximity ligation reagents by releasing a highly reactive fluorophore that tags nearby cellular material is described. It is further demonstrated that it is possible to create an influenza virus-specific reagent, which can specifically detect influenza virus infections in mammalian cells. These reagents have potential use as specific histological probes independent of viral antigenicity and, therefore, offer some advantages over commonly used anti-neuraminidase antibodies.
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