期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 16, 页码 4149-4153出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201400776
关键词
aerobic oxidation; alpha-amination; beta-ketocarbonyls; enamine catalysis; organocatalysis
资金
- Natural Science Foundation of China [21390400, 21025208, 21202171]
- National Basic Research Program of China [2011CB808600]
We describe herein an unprecedented asymmetric alpha-amination of beta-ketocarbonyls under aerobic conditions. The process is enabled by a simple chiral primary amine through the coupling of a catalytic enamine ester intermediate and a nitrosocarbonyl (generated in situ) derived from N-hydroxycarbamate. The reaction features high chemoselectivity and excellent enantioselectivity for a broad range of substrates.
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