期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 4, 页码 1231-1235出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201408874
关键词
carbene radicals; cobalt; Kornblum-DeLaMare reaction; radical reactions; tandem reactions
资金
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Natural Science Foundation of China [21272165]
The interception of cobalt-based carbene radicals with -aminoalkyl radicals was combined with the Kornblum-DeLaMare reaction and provides -ester--amino ketones, which are otherwise difficult to obtain in high chemoselectivity. Mechanistically, this transformation is an interplay of cobalt-based carbene radicals, organoradicals, and ionic intermediates and involves the construction of two CC bonds and one CO bond in a one-pot process. The reaction also features a wide substrate scope and is highly efficient and insensitive to moisture and air.
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