期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 7, 页码 1818-1821出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201310929
关键词
bridged ring systems; intramolecular Michael addition; monoterpene indole alkaloids; quaternary carbon atoms; total synthesis
资金
- EPFL (Switzerland)
- Swiss National Science Foundation (SNSF)
A total synthesis of aspidophyllineA, a pentacyclic akuammiline-type monoterpene indole alkaloid, is described. The synthesis features: 1)rapid access to a fully functionalized dihydrocarbazole through the desymmetrization of readily available 2-allyl-2-(o-nitrophenyl)cyclohexane-1,3-dione; 2)an intramolecular azidoalkoxylation of an enecarbamate to install both the furoindoline ring and the azido functionality; and 3)an intramolecular Michael addition for the construction of the 2-azabicyclo[3.3.1]nonane ring system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据