期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 8, 页码 2134-2137出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201309022
关键词
asymmetric catalysis; cycloadditions; heterocycles; natural products; zinc
资金
- German Federal Ministry for Education and Research through the German National Genome Research Network-Plus (NGFNPlus) [BMBF 01GS08104]
- European Research Council (ERC) [268309]
The imino Diels-Alder reaction is an efficient method for the synthesis of aza-heterocycles. While different stereo- and enantioselective inverse-electron-demand imino Diels-Alder (IEDIDA) reactions have been reported before, IEDIDA reactions including electron-deficient dienes are unprecedented. The first enantioselective IEDIDA reaction between electron-poor chromone dienes and cyclic imines, catalyzed by zinc/binol complexes is described. The novel reaction provides a facile entry to a natural product inspired collection of ring-fused quinolizines including a potent modulator of mitosis.
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