Article
Chemistry, Physical
C. Breazu, O. Rasoga, M. Socol, P. Ganea, T. Tite, E. Matei, F. Stanculescu, A. Stanculescu
Summary: This study investigates the impact of carbon nanomaterials and lipids on the aggregation properties of the amyloid beta/Aβ(1-42) layers, showing that the presence of cholesterol inhibits fibril formation and the developed structures are correlated with the surface characteristics of the films.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ewelina Stefaniak, Elena Atrian-Blasco, Wojciech Goch, Laurent Sabater, Christelle Hureau, Wojciech Bal
Summary: This study investigated the effect of Cu-II on the aggregation of A beta(1-40) and A beta(4-40). It was found that substoichiometric Cu-II concentrations accelerated aggregation, while superstoichiometric Cu-II inhibited fibril formation. The interaction between Cu-II, A beta(4-40), and A beta(1-40) resulted in significant changes in the aggregation process.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Kyu-Ho Shim, Sungchan Ha, Jin Seung Choung, Jee In Choi, Daniel Youngsuk Kim, Jong Moon Kim, MinYoung Kim
Summary: This study highlighted the potential therapeutic effects of EPO administration on Alzheimer's disease, including improvements in memory function, modulation of neurotransmitters, anti-inflammatory action, and neurogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Himanshu Singh, Sumit Sharma
Summary: This study reveals that the hydration free energies of linear alkanes are governed by the small length-scale hydrophobic effect, unlike the case of large spherical solutes.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2022)
Article
Biochemistry & Molecular Biology
Ly Porosk, Heleri Heike Hark, Renata Naporano Bicev, Ilja Gaidutsik, Jekaterina Nebogatova, Eger-Jasper Armolik, Piret Arukuusk, Emerson Rodrigo da Silva, Ulo Langel
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease that causes dementia, and its pathophysiological dynamics are driven by genetics with high heterogeneity in biological alterations and causes. The disease is characterized by the progression of aggregated amyloid-beta (A beta) or Tau neurofibrillary tangles. Current treatments for AD are not efficient, but recent breakthroughs have led to the discovery of potential therapeutic targets such as reducing brain inflammation and limiting A beta aggregation. This study demonstrates the successful use of A beta interacting protein sequences, particularly derived from Transthyretin, to reduce or target amyloid aggregation, and also predicts anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Andrea Usenik, Marija Aleskovic, Suncica Roca, Iva Markus, Marina Sekutor, Josip Pozar
Summary: Understanding the forces governing hydrophobically driven inclusion is crucial for the utilization of non-polar synthons. This study sheds light on the factors determining the stability of complexes with large guests and provides insights into the hydration thermodynamics.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nuria Mazo, Claudio D. Navo, Francesca Peccati, Jacopo Andreo, Cristina Airoldi, Gildas Goldsztejn, Pierre Carcabal, Imanol Usabiaga, Mariona Sodupe, Stefan Wuttke, Jesus H. Busto, Jesus M. Peregrina, Emilio J. Cocinero, Gonzalo Jimenez-Oses
Summary: This study presents the synthesis and characterization of peptides containing variations of the beta-amyloid hydrophobic core, as well as the use of experimental and computational techniques to investigate their properties in the gas phase, solid state, and aqueous solution. The introduction of a cyclic sulfamidate group effectively restricts and stabilizes the secondary structure of these hybrid peptides, maintaining this conformational bias in different environments. These peptides also exhibit moderate activity as beta-sheet breaker peptides, inhibiting the aggregation of beta-amyloid in vitro.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Medicine, General & Internal
Alessandro Martorana, Martina Assogna, Vincenzo De Lucia, Caterina Motta, Chiara G. Bonomi, Francesca Bernocchi, Martina G. Di Donna, Giacomo Koch
Summary: Cognitive reserve is a concept that involves individual abilities to cope with changes, and it can help predict and prevent cognitive decline and Alzheimer's disease. By maintaining environmental enrichment, efficient synaptic plasticity mechanisms can protect cognitive reserve, keeping repair mechanisms effective and promoting successful aging.
Article
Chemistry, Medicinal
Valeria Romanucci, Maddalena Giordano, Gaetano De Tommaso, Mauro Iuliano, Roberta Bernini, Mariangela Clemente, Sara Garcia-Vinuales, Danilo Milardi, Armando Zarrelli, Giovanni Di Fabio
Summary: Alzheimer's disease is a multifactorial pathology involving amyloid beta aggregation and oxidative stress. A new study has developed tyrosol phosphodiester derivatives (TPDs) with antioxidant properties and the ability to inhibit Aβ protein aggregation. TPDs containing a catechol moiety showed promising activity in inhibiting Aβ aggregation and chelating biometals.
Article
Clinical Neurology
Sourin Bhuniya, Manish Goyal, Nilotpal Chowdhury, Priyadarshini Mishra
Summary: Patients with obstructive sleep apnea have higher serum levels of amyloid-beta and tau proteins, which are associated with nocturnal oxygen saturation and changes in sleep architecture. Monitoring for signs of cognitive impairment and treating obstructive sleep apnea may reverse neurodegenerative changes and prevent cognitive impairment.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Mattias Tornquist, Sara Linse
Summary: Chirality, a fundamental feature of asymmetric molecules, plays a critical role in the growth and toxicity of amyloid fibrils. The study found a strong enantio-selectivity in the auto-catalytic process of secondary nucleation, which highlights the significance of chirality in strain propagation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Geriatrics & Gerontology
Mari Aksnes, Ann Tiiman, Trine Holt Edwin, Lars Terenius, Nenad Bogdanovic, Vladana Vukojevic, Anne-Brita Knapskog
Summary: Accurate biomarkers for Alzheimer's disease are crucial for early diagnosis and intervention. This study found that levels of nanoplaques in cerebrospinal fluid were increased in patients with AD biomarkers, but did not improve patient classification compared to core biomarkers alone. Dynamic changes in nanoplaque concentration and size throughout AD stages should be further explored.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Nathan Meyer, Nicolas Arroyo, Jean-Marc Janot, Mathilde Lepoitevin, Anna Stevenson, Imad Abrao Nemeir, Veronique Perrier, Daisy Bougard, Maxime Belondrade, Didier Cot, Jeremy Bentin, Fabien Picaud, Joan Torrent, Sebastien Balme
Summary: This study investigates the impact of nanoscale geometry and molecular crowding on Aβ fibril sensing using nanopore technology. It was found that a conical nanopore functionalized with PEG 5 kDa can discriminate fibril size, while a bullet-like-shaped nanopore enhances current amplitude and dwell time. However, a nanopore crowded with PEG 20 kDa increases relative current blockade without improving fibril discrimination compared to the bullet-shaped nanopore.
Article
Multidisciplinary Sciences
Wei Wang, Lin Shi, Hong Ma, Shiguang Zhu, Yaqiong Ge, Kai Xu
Summary: This study investigates the clinical application value of plasma amyloid (31-42), phosphorylated tau 181, and MRI parameters for cognitive impairment in older adults aged 75 and above. The results indicate that plasma markers are not significantly associated with cognitive impairment, while periventricular WMH, lateral ventricle body index, and cortical atrophy are related to cognitive impairment. The study suggests that MRI parameters have important clinical significance for early assessment and dynamic observation.
Review
Biochemistry & Molecular Biology
Anna Sulatskaya, Anastasiia O. Kosolapova, Alexander G. Bobylev, Mikhail Belousov, Kirill S. Antonets, Maksim Sulatsky, Irina M. Kuznetsova, Konstantin K. Turoverov, Olesya Stepanenko, Anton A. Nizhnikov
Summary: Both amyloids and beta-barrel proteins have beta-sheet-rich structures, with the latter being able to form functional amyloids in vivo. These beta-barrel amyloid proteins can interact with each other and form toxic oligomers, potentially contributing to the development of amyloidoses. Rapidly growing discoveries suggest that the number and diversity of functions of amyloid-forming beta-barrel proteins are significantly greater than currently understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)