期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 17, 页码 4386-4389出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201400459
关键词
cross-couple; Negishi reaction; palladium; PEPPSI; transition-metal catalysis
资金
- NSERC (Canada)
- Ontario Research Fund (ORF)
The role of halide salt additives has been investigated in the Negishi reaction involving aryl zinc reagents. Diarylzincs readily transmetallate to Pd in relatively non-polar media (e.g., THF) with zero salt present and coupling proceeds. Arylzinc halides (ArZnX) fail to couple in THF without salt, but do couple with it. However, unlike alkylzincs that form higher-order zincates in order to facilitate transmetallation, all that is required with arylzincs in an increase in solvent dielectric as even ZnX2 works as an additive, which completely terminates alkylzinc coupling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据