期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 48, 页码 13102-13105出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201406898
关键词
crystal engineering; microstructure; nanoindentation; polymorphism; X-ray diffraction
资金
- CSIR, India
- Department of Science and Technology, India
- Danish Council for Independent Research/Natural Sciences [1323-00122]
Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.
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