期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 3, 页码 796-800出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407854
关键词
DNA; DNA cross-linking; DNA nanostructures; imines; reversible bonding
资金
- Alexander von Humboldt Foundation
- Deutsche Forschungsgemeinschaft [SFB1032 (TP-A5), SFB749 (TP-A4)]
- Cluster of Excellence Nanosystems Initiative Munich (NIM)
We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.
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