Biosynthesis of the Structurally Unique Polycyclopropanated Polyketide-Nucleoside Hybrid Jawsamycin (FR-900848)

ATrans-Acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248

(2013) Yi Zou et al.   CHEMBIOCHEM

Biochemical Determination of Enzyme-Bound Metabolites: Preferential Accumulation of a Programmed Octaketide on the Enediyne Polyketide Synthase CalE8

(2013) Katherine Belecki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

(2013) Tom Bretschneider et al.   NATURE

Evolutionary Imprint of Catalytic Domains in Fungal PKS-NRPS Hybrids

(2012) Daniela Boettger et al.   CHEMBIOCHEM

Characterization of Yatakemycin Gene Cluster Revealing a Radical S-Adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

F420-dependent enzymes – potential for applications in biotechnology

(2012) Matthew Taylor et al.   TRENDS IN BIOTECHNOLOGY

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Characterization of LipL as a Non-heme, Fe(II)-dependent α-Ketoglutarate:UMP Dioxygenase That Generates Uridine-5′-aldehyde during A-90289 Biosynthesis

(2011) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthetic Origin and Mechanism of Formation of the Aminoribosyl Moiety of Peptidyl Nucleoside Antibiotics

(2011) Xiuling Chi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical S-adenosylmethionine enzymes: Mechanism, control and function

(2011) Martin R. Challand et al.   NATURAL PRODUCT REPORTS

Identification of a Napsamycin Biosynthesis Gene Cluster by Genome Mining

(2010) Leonard Kaysser  et al.   CHEMBIOCHEM

Unexpected Abundance of Coenzyme F420-Dependent Enzymes in Mycobacterium tuberculosis and Other Actinobacteria

(2010) J. D. Selengut et al.   JOURNAL OF BACTERIOLOGY

Complexity and simplicity in the biosynthesis of enediyne natural products

(2010) Zhao-Xun Liang   NATURAL PRODUCT REPORTS

Dissecting tunicamycin biosynthesis by genome mining: cloning and heterologous expression of a minimal gene cluster

(2010) Filip J. Wyszynski et al.   Chemical Science

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metamorphic enzyme assembly in polyketide diversification

(2009) Liangcai Gu et al.   NATURE

Unprecedented biological cyclopropanation in the biosynthesis of FR-900848

(2008) Tetsuo Tokiwano et al.   CHEMICAL COMMUNICATIONS