期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 50, 页码 13746-13750出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407061
关键词
DNA recognition; nucleic acid recognition; RNA recognition; triptycenes
资金
- University of Pennsylvania
- National Science Foundation
- National Institutes of Health including HRMS [NIH RR-023444]
- National Institutes of Health including MALDI-MS [NSF MRI-0820996]
- NIH [T32 GM07133]
The modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein, we describe a new class of structure-specific nucleic acid junction stabilizers based on a triptycene scaffold. Triptycenes provide significant stabilization of DNA and RNA three-way junctions, providing a new scaffold for the development of nucleic acid junction binders with enhanced recognition properties. Additionally, we report cytotoxicity and cell uptake data in two human ovarian carcinoma cell lines.
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