Review
Chemistry, Analytical
Pradakshina Sharma, Shariq Suleman, Asim Farooqui, Wajid Ali, Jagriti Narang, Shweta J. Malode, Nagaraj P. Shetti
Summary: This article introduces the diagnosis strategies for Ebola virus and the use of advanced technologies such as artificial intelligence and the internet of medical things for disease diagnosis. Timely disease identification and treatment optimization are crucial for controlling infectious disease outbreaks.
MICROCHEMICAL JOURNAL
(2022)
Review
Materials Science, Multidisciplinary
Mariadel Mar Gonzalez del Campo, Andreu Vaquer, Roberto de la Rica
Summary: In recent years, paper has become a widely used material for developing various types of sensors, and a polymer-based toolbox has emerged to enhance the functionalities of these devices. This article compiles examples from recent literature on microfluidic systems and polymer-based transducers implemented in paper-based analytical platforms. The use of printing methods to pattern polymers allows for mass production of these advanced paper-based devices without requiring specialized facilities.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Analytical
Bu-yue Zhang, Lei Shi, Xiao-ying Ma, Lu Liu, Yao Fu, Xiu-feng Zhang
Summary: This review focuses on functional nucleic acid-based biosensors for detecting Pb2+ from 2010 to 2020. The biosensors are categorized into colorimetric, fluorometric, and electrochemical biosensors based on different reported signals. The mechanism of action and detection effectiveness of each biosensor are explained, and the current situation and future research direction of nucleic acid biosensors for Pb2+ detection are summarized.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Woohyun J. Moon, Yongjie Yang, Juewen Liu
Summary: Since 1994, deoxyribozymes or DNAzymes have been in vitro selected to catalyze various types of reactions, with metal ions playing a critical role in DNAzyme catalysis, especially Zn2+. Zn2+ has good biocompatibility and can be used for intracellular applications, binding to both the phosphate backbone and the nucleobases of DNA.
Review
Chemistry, Analytical
Josune J. Ezenarro, Jordi Mas, Xavier Munoz-Berbel, Naroa Uria
Summary: This review summarizes the recent advances in bacterial concentration/detection platforms, with a focus on the concentration strategy. By introducing and comparing five concentration strategies, namely centrifugation, filtration, magnetic separation, electric separation, and acoustophoresis, the review aims to facilitate the development of future platforms for fast, sensitive, and in situ bacterial detection in real samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Yuqing Li, Mohamad Zandieh, Juewen Liu
Summary: This study investigates the effect of butanol on the activity of RNA-cleaving DNAzymes, and found that butanol can significantly enhance the activity of certain DNAzymes but inhibits them when divalent metal ions are used. The main driving force for the enhanced DNAzyme activity is attributed to the concentration effect due to butanol dehydration, providing insights into the interplay between DNA, metal ions, and organic solvents that may be useful for developing sensitive biosensors.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Analytical
Neda Bagheri, Vincenzo Mazzaracchio, Stefano Cinti, Noemi Colozza, Concetta Di Natale, Paolo Antonio Netti, Mohammad Saraji, Simona Roggero, Danila Moscone, Fabiana Arduini
Summary: The research utilizes a paper-based sensor to detect copper ions in bodily fluids, making full use of the environmentally friendly characteristics of filter paper to achieve highly sensitive detection of copper ions. The application in biological matrices demonstrates good accuracy of the novel eco-designed analytical tool.
ANALYTICAL CHEMISTRY
(2021)
Review
Medical Laboratory Technology
Srividya Oruganti, Sai Lakshmi Gundimeda, Viswanath Buddolla, Buddolla Anantha Lakshmi, Young-Joon Kim
Summary: Viruses cause diseases and pose serious health risks. Paper-based diagnostic chips are becoming increasingly popular due to their speed, accuracy, convenience, and cost-effectiveness. These tests are ideal for point-of-care applications, particularly in remote and underdeveloped areas where traditional diagnostic methods are not readily available.
CLINICA CHIMICA ACTA
(2023)
Review
Food Science & Technology
Aristeidis S. Tsagkaris, Jana Pulkrabova, Jana Hajslova
Summary: This study critically reviews the available screening methods for pesticide residues based on optical detection during the period 2016-2020, emphasizing the importance and potential of optical biosensors in the field of food safety. The utilization of nanomaterials and smartphone technology in optical detection is also discussed as promising advancements in the field.
Article
Chemistry, Analytical
Maria Celia Tavares, Karoliny Almeida Oliveira, Angelo de Fatima, Wendell K. T. Coltro, Josue Carinhanha Caldas Santos
Summary: This study introduces a paper-based analytical device (UrePAD) for colorimetric determination of urease activity in soils, offering advantages such as low cost and simplicity in handling. The results showed that UrePAD was effective in determining urease activity and screening inhibitors in various soil samples and urease inhibitors.
Article
Chemistry, Analytical
Chunlei Yan, Yang Sun, Mingru Yao, Xiaoyu Jin, Qingli Yang, Wei Wu
Summary: This paper presents a pH-responsive nanoparticle-based automatic device for dual detection of pathogenic bacteria. The device utilizes a colorimetric sensor for signal amplification. The method achieves high sensitivity and can distinguish between Escherichia coli and Salmonella typhimurium.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Takeshi Komatsu, Ryoga Maeda, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
Summary: This study presents a novel paper-based analytical device for measuring ascorbic acid and pH, demonstrating improved sensitivity and reproducibility compared to traditional methods. The device eliminates the need for complex pipetting manipulation, making it more user-friendly.
Article
Chemistry, Multidisciplinary
Shuwen Qian, Dingran Chang, Jimmy Gu, Bruno J. Salena, Yingfu Li
Summary: Clostridium difficile is a common bacteria that causes an infectious disease, and there is a need for rapid diagnostic tests. Researchers have developed a RNA-cleaving fluorogenic DNAzyme probe, RFD-CD2, which can detect different pathogenic strains of C. difficile with high specificity. RFD-CD2 can detect C. difficile at a concentration as low as 100 CFU/mL, making it an attractive molecular probe for rapid diagnosis of CDI.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Pamula Sri Sruthi, Sivasamy Balasubramanian, Ponnusamy Senthil Kumar, Ashish Kapoor, Muthamilselvi Ponnuchamy, Meenu Mariam Jacob, Sivaraman Prabhakar
Summary: This study developed a miniaturized paper-based pH detection platform using natural dye extracted from red cabbage. The device's performance at different pH values was quantitatively assessed through digital image analysis, and the a* parameter in the CIEL*a*b* color space model was used for quantifying pH variations. The simplicity of fabrication, eco-friendliness due to the use of paper and natural dye, and suitability for in situ pH measurements make this methodology promising for future chemical sensor technologies.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biotechnology & Applied Microbiology
Benjamin Shemer, Etai Shpigel, Carina Hazan, Yossef Kabessa, Aharon J. Agranat, Shimshon Belkin
Summary: This article discusses the optimization of a genetically engineered microbial sensor strain for the remote detection of landmines. The experiments showed that these sensor bacteria could sensitively detect buried explosives in both laboratory and field conditions, marking a significant advancement in landmine detection technology.
MICROBIAL BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yan Zhao, Weiheng Kong, Peng Wang, Guosheng Song, Zhi-Ling Song, Yue Yang, Youjuan Wang, Baoli Yin, Pengfei Rong, Shuangyan Huan, Xiao-Bing Zhang
Summary: The study demonstrates a sophisticated therapeutic strategy to selectively interfere with chaotic tumors that have devastating nucleic acid damage properties, overcoming therapeutic barriers. This strategy involves combining enzymes and nanozymes through biomineralization, disrupting metabolism by consuming glucose and inhibiting nutrition supply for nucleic acid repair, resulting in indiscriminate nucleic acid damage ability.
Article
Chemistry, Multidisciplinary
Shuai Xu, Wenjing Pan, Tian-Bing Ren, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Summary: This study focuses on the design, optical performance, imaging mechanisms, and applications of various fluorophores to achieve high-contrast bioimaging in complex physiological conditions. The orderly assembly of specific molecular dyes is found to be an effective strategy in overcoming this challenge.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Yongchao Liu, Lili Teng, Baoli Yin, Hongmin Meng, Xia Yin, Shuangyan Huan, Guosheng Song, Xiao-Bing Zhang
Summary: Photoacoustic imaging technology combines the advantages of optical and acoustic imaging, offering high imaging depth and resolution for molecular imaging. Activatable molecular PA probes show promise for real-time molecular visualization and precise biomedical diagnosis. These probes can alter their PA intensities upon reacting with specific targets or biological events, providing new possibilities for biomedical applications.
Article
Engineering, Biomedical
Xiaofeng Lou, Tian -Bing Ren, Haoming Chen, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Summary: Lysosomes are important organelles involved in the degradation of biological macromolecules and pathogens. Current fluorescent probes for imaging lysosomal analytes suffer from practical issues. To address these issues, we proposed a new strategy using an optimized solid-state fluorophore HDPQ to design lysosomal enzyme probes. The novel lysosomal probe exhibited excellent performance in terms of anti-pH interference, signal-to-noise ratio, and long-term in situ imaging ability. This strategy could be a potential platform for developing high-fidelity fluorescent probes for imaging lysosomal enzymes.
Review
Chemistry, Multidisciplinary
Tu Tingting, Huan Shuangyan, Ke Guoliang, Zhang Xiaobing
Summary: This review summarizes the design and applications of functional xeno nucleic acids in the biomedical field, highlighting their wide application in screening, sensing, and imaging, and addressing the limitations of natural nucleic acids.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2022)
Review
Chemistry, Multidisciplinary
Tingting Tu, Shuangya Huan, Guoliang Ke, Xiaobing Zhang
Summary: Functional nucleic acids (FNAs) have been widely applied in screening, sensing, and imaging fields, but their potential application in biomedicine is limited by the drawbacks of natural nucleic acids (DNA/RNA). Xeno nucleic acids (XNAs), with chemically modified sugar groups, possess improved biological properties, making them an attractive material for biomedical applications. In this review, the design and applications of functional XNAs in the biomedical field are summarized.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2022)
Article
Chemistry, Multidisciplinary
Baoli Yin, Qiaoqiao Qin, Zhe Li, Youjuan Wang, Xinlin Liu, Yongchao Liu, Shuangyan Huan, Xiaobing Zhang, Guosheng Song
Summary: The study developed a novel NIR-II molecule with improved activation efficiency and targeted therapy for tongue cancer through rational design of the molecular structure.
Article
Biochemical Research Methods
Si-Min Wang, Xiaofeng Lou, Shuai Xu, Zhi-Ling Song, Tian-Bing Ren, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Summary: Fluorescence imaging is widely used in biomedical research and clinical diagnostics. D-A type fluorophores are commonly used for fluorescence imaging due to their easy synthesis and excellent photophysical properties. However, the solvatochromic nature of traditional D-A type fluorophores reduces the fluorescence brightness in biological systems. In this study, we developed a novel HIEE fluorophore MTC with typical anti-solvatochromic fluorescence, and the activated fluorescent probe designed based on MTC showed excellent imaging performance. We believe that fluorophores with typical anti-solvatochromic fluorescence could be a useful platform for designing fluorescent probes for high-brightness imaging in biological systems.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Shuai Xu, Wenjing Pan, Lanlan Chen, Sulai Liu, Tian-Bing Ren, Hong-Wen Liu, Yongchao Liu, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Summary: Developing a chemiluminescence probe with slow kinetic profile is challenging but crucial for improving analytical sensitivity. A novel strategy was reported in this study to achieve long-lasting in vivo imaging by introducing hydrogen-bond-driven self-assembled dye HPQ to Schaap's dioxetane. The self-assembled chemiluminophore HPQCL-Cl showed prolonged half-life and constant emission, enabling long-lasting imaging and image-guided clinical surgery.
Article
Chemistry, Analytical
Yuzhi Ouyang, Yancao Chen, Jinhui Shang, Shijie Sun, Xiangbin Wang, Shuangyan Huan, Bin Xiong, Xiao-Bing Zhang
Summary: The development of convenient and robust strategies is essential to analyze the efficacy of antiviral drugs and mutation-induced resistance, in order to prevent the spread of pathogenic viruses and protect public health. This study presents a simple single-particle detection strategy using spike protein-functionalized AuNPs as virus-like plasmonic nanoprobes, for quick analysis of anti-SARS-CoV-2 drugs and mutation-induced resistance. The strategy allows for the detection of changes in nano-assemblies upon drug treatment, providing a promising method for the discovery and efficacy evaluation of anti-infective drugs against different pathogenic viruses.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lingling Lei, Bin Nan, Fengrui Yang, Guoqiang Guan, Juntao Xu, Li Xu, Renye Yue, Youjuan Wang, Shuangyan Huan, Xia Yin, Xiao-Bing Zhang, Guosheng Song
Summary: A dual metabolism inhibitor, Zn-carnosine metallodrug network nanoparticles (Zn-Car MNs), has been developed to effectively inhibit both OXPHOS and glycolysis, leading to apoptosis of cancer cells by decreasing ATP production. Compared to the classic copper chelator (TM), Zn-Car MNs showed superior antitumor efficacy in breast cancer and colon cancer models.
Article
Chemistry, Analytical
Yurong Feng, Shuai Xu, Haowei Guo, Tian-Bing Ren, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Summary: This study achieved sensitive and early diagnosis of acute kidney injury (AKI) through the development of a chemiluminescent probe CL-Pa. The probe can detect drug-induced AKI through urinalysis and has great potential for early diagnosis of AKI and evaluation of anti-AKI drugs clinically.
ANALYTICAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Shiyi Liao, Youjuan Wang, Zhe Li, Ying Zhang, Xia Yin, Shuangyan Huan, Xiao-Bing Zhang, Sulai Liu, Guosheng Song
Summary: A novel near-infrared organic afterglow nanoparticle was developed to visualize reactive oxygen species (ROS) during immunogenic cell death, with high signal to noise ratio. The nanoparticle induced immunogenic cell death of cancer cells and caused immune responses, providing a non-invasive tool for predicting the degree of immunogenic cell death during ROS-mediated cancer therapy.
Article
Chemistry, Multidisciplinary
Yurong Feng, Shuai Xu, Zhi-Ling Song, Tian-Bing Ren, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Summary: In this study, we introduced an activatable chemiluminescent probe CL-O-3 for high-contrast imaging of O(3) in vivo. CL-O-3 demonstrated excellent selectivity towards O-3 and could evaluate the degree of inflammation by detecting endogenous O-3 levels in acute inflamed mice.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Ke Li, Shuai Xu, Mengyi Xiong, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang
Summary: In situ monitoring of bioactive molecules is crucial for understanding various biological events, while targeting therapy in situ can improve treatment outcomes and reduce side effects. Strategies for in situ imaging and precision treatment are emphasized in this review, focusing on the application of molecular immobilization techniques.
CHEMICAL SOCIETY REVIEWS
(2021)