期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 46, 页码 12613-12617出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201404100
关键词
colloids; cytotoxicity; gold; nanoparticles; polymers
资金
- Swiss National Science Foundation [PP00P2_123373]
- Adolphe Merkle Institute
- FriMat
- Swiss National Science Foundation (SNF) [PP00P2_123373] Funding Source: Swiss National Science Foundation (SNF)
The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor, polyvinyl acetate, which is then transformed into its hydrophilic analogue, polyvinyl alcohol. This polymer was chosen due to its well-established biocompatibility, tunable stealth properties, tunable hydrophobicity, and high degree of functionality. The biocompatibility of the functionalized GNRs was tested by exposing them to primary human blood monocyte derived macrophages; the advantages of tunable hydrophobicity were demonstrated with the long-term stable encapsulation of a model hydrophobic drug molecule.
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