Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Analytical
Baoli Dong, Shijing Li, Yan Wang, Xiaochan Tang, Ruifei Wang, Xiuqi Kong, Tao Yue
Summary: In this review, various fluorescent responsive probes (based on small organic molecules, nanoparticles, or polymers) for the study of ferroptosis were summarized, and their design strategies, sensing performance, and imaging applications were comprehensively discussed. Furthermore, some insights for the design of novel fluorescent responsive probes to study ferroptosis were briefly provided.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Samridhi Patel, Sisir Patra, Samiksha Chand, Raman K. Singh, Indrani Singh, Girish Chandra
Summary: Reactive oxygen species (ROS) such as H2O2 and singlet oxygen (1O2) play important roles in living systems. It is necessary to determine the accurate concentrations of H2O2 and 1O2 in different systems for safety purposes. In this study, a chemodosimeter approach using diazo compounds was used to investigate the interactions of H2O2 and 1O2 through spectroscopy and determine the reaction mechanisms. The isolated products showed an unusual denitration reaction during interactions with H2O2 and the formation of an interesting blue-colored para-quinone derivative.
Review
Chemistry, Inorganic & Nuclear
Yongqing Zhou, Xiaofeng Yang, Jing Zhang, Shuai Xu, Juan Li, Wenshou Wang, Mei Yan
Summary: Reactive nitrogen species (RNS), including nitric oxide (NO or NO.), peroxynitrite anion (ONOO-) and nitroxyl (HNO), play important roles in physiological, pathological and pharmacological processes. Abnormal variations in RNS concentrations are closely associated with the occurrence and progression of numerous diseases. Therefore, it is significant to visualize RNS for a better understanding of their distribution, roles, functions, interactions and mechanisms in biological systems. Fluorescence imaging technique and small molecule fluorescent probes have been widely used for the detection and monitoring of RNS in living systems. In this review, recent advances in small molecule fluorescent probes for monitoring NO, ONOO- and HNO are summarized, including their design strategies, recognition mechanisms and biological applications.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Optics
Koki Kubota, Naoya Miyajima, Hideto Sakane
Summary: The fluorescence properties of NH4-form Y-type zeolites calcined under different atmospheres and temperatures were studied. Various analyses were performed on the calcined zeolites to elucidate the origin of the fluorescence. The results showed that the collapse of the SiO4 tetrahedron in the zeolite resulted in the generation of E'-center and non-bridging oxygen hole center (NOBHC), as well as changes in absorption peaks in the FT-IR spectra.
JOURNAL OF LUMINESCENCE
(2022)
Review
Chemistry, Multidisciplinary
Yang Zhong, Lulu Yang, Yunyun Zhou, Juanjuan Peng
Summary: Liver injury-related diseases have attracted attention due to their unpredictability, acute onset, and severe consequences. Fluorescence imaging techniques have been used for the diagnosis of liver injury, offering comprehensive information about the lesion site. This article provides a summary and discussion of the design strategies and applications of fluorescent biosensors responsive to biomarkers involved in liver injury.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Analytical
Mei-Jia Hou, Zhi-Qing Wang, Jun-Tao Chen, Zhi-Ke Tan, Guo-Jiang Mao, Junjie Fei, Chun-Yan Li
Summary: This study developed a fluorescent nanoprobe for sequential detection of ATP and ONOO-, showing potential for accurate cancer diagnosis by distinguishing cancer cells from normal cells.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Pei Huang, Yongkang Yue, Caixia Yin, Fangjun Huo
Summary: Intracellular redox homeostasis plays a significant role in pathophysiology. Fluorescent probes that can detect both reactive oxygen species (ROS) and reactive sulfur species (RSS) simultaneously or sequentially are crucial for understanding the correlation and pathophysiological effects of these two signaling molecules in oxidative stress. These dual detection probes provide strong support for the study of redox homeostasis in complex cellular environments.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Yuan-Xiang Li, Dong-Tai Xie, Ya-Xi Yang, Zhao Chen, Wu-Yingzheng Guo, Wen-Chao Yang
Summary: Enzymes, as biological catalysts, play a vital role in controlling metabolic reactions. The regulation and amount of enzymes in living cells are indicators of the cell's metabolic status. Small-molecule fluorescent probes are of interest due to their high sensitivity, selectivity, and potential for automated detection. However, designing an ideal fluorescent probe for versatile purposes is challenging. In the future, the focus will be on improving the selectivity, sensitivity, and penetration ability of enzyme-targeting fluorescent probes, as well as coupling them with other imaging molecules/technologies.
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Diogo Alves Galico, Italo Odone Mazali, Fernando Aparecido Sigoli
Summary: In this study, a polydimethylsiloxane membrane with two emitter groups attached to the structure was synthesized. The membrane can function as a bifunctional temperature and oxygen ratiometric optical probe, analyzing the effects of temperature changes and oxygen levels on the ratio of emission components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Inorganic & Nuclear
D. Mouchel Dit Leguerrier, R. Barre, J. K. Molloy, F. Thomas
Summary: Lanthanides complexes are widely used in medicine and biology due to their unique properties for magnetic resonance imaging and luminescence. Recent advances in utilizing redox-reactive ligands have overcome the limitations of lanthanides in redox monitoring, expanding their applications in detecting biological relevant ROS, RNS and redox status.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Wei Zhang, Jie Ren, Jun Lu, Ping Li, Wen Zhang, Hui Wang, Bo Tang
Summary: The relationship between reactive oxygen species (ROS) and levels of protein phosphorylation was investigated using a metal-organic framework-based fluorescent nanoprobe. The probe achieved simultaneous recognition of ROS and phosphorylation sites, improving imaging sensitivity with the two-photon property of the ROS recognition unit. This work provides feasible fluorescence tools for revealing the pathogenesis of diseases.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Enrico Falcone, Bertrand Vileno, Mai Hoang, Laurent Raibaut, Peter Faller
Summary: The study presented a novel fluorescent probe designed for measuring dynamic fluctuations of CuII in biological samples and application in slightly acidic media, showing potential benefits for these purposes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ryan J. Mailloux
Summary: Mitochondria primarily produce superoxide and hydrogen peroxide, with the latter being considered the main ROS emitted into the cell. While H2O2 is now recognized as a central component in redox signaling, it has been suggested that superoxide may also act as a signal in mammalian cells.
