Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

(2013) Volker Hessel et al.   ChemSusChem

The role of flow in green chemistry and engineering

(2013) Stephen G. Newman et al.   GREEN CHEMISTRY

β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

(2013) Hans Hilpert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

(2013) Bimbisar Desai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

(2013) Werngard Czechtizky et al.   ACS Medicinal Chemistry Letters

Micro Total Analysis Systems: Fundamental Advances and Applications in the Laboratory, Clinic, and Field

(2012) Michelle L. Kovarik et al.   ANALYTICAL CHEMISTRY

The integration of flow reactors into synthetic organic chemistry

(2012) Ian R. Baxendale   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of sensitivity and specificity in leaky droplet-based assays

(2012) Yunhan Chen et al.   LAB ON A CHIP

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Flow chemistry synthesis of zolpidem, alpidem and other GABAAagonists and their biological evaluation through the use of in-line frontal affinity chromatography

(2012) Lucie Guetzoyan et al.   Chemical Science

Droplet-Based Microfluidic Flow Injection System with Large-Scale Concentration Gradient by a Single Nanoliter-Scale Injection for Enzyme Inhibition Assay

(2011) Long-Fei Cai et al.   ANALYTICAL CHEMISTRY

Micro Total Analysis Systems for Cell Biology and Biochemical Assays

(2011) Michelle L. Kovarik et al.   ANALYTICAL CHEMISTRY

Getting pharmaceutical R&D back on target

(2011) Mark E Bunnage   Nature Chemical Biology

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

High-resolution dose-response screening using droplet-based microfluidics

(2011) O. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

(2010) Marcus Baumann et al.   MOLECULAR DIVERSITY

Microfluidic Devices for Bioapplications

(2010) Leslie Y. Yeo et al.   Small

Continuous-flow organic synthesis: a tool for the modern medicinal chemist

(2009) Charlotte Wiles et al.   Future Medicinal Chemistry

Micro- and nanofluidic systems for high-throughput biological screening

(2008) Jongin Hong et al.   DRUG DISCOVERY TODAY