Overcoming the Unexpected Functional Inversion of a PqsR Antagonist inPseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent TargetingpqsQuorum Sensing

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

(2013) Kieron M. G. O'Connell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Choosing an Appropriate Infection Model to Study Quorum Sensing Inhibition in Pseudomonas Infections

(2013) Evelina Papaioannou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development and validation of a UHPLC–MS/MS procedure for quantification of the Pseudomonas Quinolone Signal in bacterial culture after acetylation for characterization of new quorum sensing inhibitors

(2013) Christine K. Maurer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

2-Aminobenzimidazole Derivatives Strongly Inhibit and DispersePseudomonas aeruginosaBiofilms

(2012) Reto Frei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

(2012) Cenbin Lu et al.   CHEMISTRY & BIOLOGY

Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors

(2012) Michael P. Storz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria

(2012) Warren R.J.D. Galloway et al.   TRENDS IN MICROBIOLOGY

Novel classes of antibiotics or more of the same?

(2011) Anthony RM Coates et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule

(2010) J. Hodgkinson et al.   JOURNAL OF BACTERIOLOGY

Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH

(2010) Jeffrey W. Schertzer et al.   MOLECULAR MICROBIOLOGY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ

(2009) G. Brackman et al.   MICROBIOLOGY-SGM

Neutrophils in cystic fibrosis

(2008) D G Downey et al.   THORAX

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY