Review
Cell & Tissue Engineering
Ghaidaa Raheem Lateef Al-Awsi, Fahad Alsaikhan, Ria Margiana, Irfan Ahmad, Indrajit Patra, Mazin A. A. Najm, Ghulam Yasin, Iroda Rasulova, Ali Thaeer Hammid, Hamzah H. Kzar, Moaed E. Al-Gazally, Homayoon Siahmansouri
Summary: Breast cancer is the second most frequently diagnosed cancer and the leading cause of cancer death in women. Mesenchymal stem cells (MSCs) are a subgroup of cells that can differentiate into multiple cell types and have been found to have various effects on tumor growth and development. Recent studies have shown that MSCs can both promote and inhibit tumor development. Exosomes (Exo) have emerged as a new mechanism of cell communication, and MSC-derived exosomes (MSCs-Exo) have been found to carry molecules that can affect the proliferation, metastasis, and drug response of breast cancer cells.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell & Tissue Engineering
Elham Ghasempour, Shilan Hesami, Elaheh Movahed, Saeed Heidari Keshel, Mohammad Doroudian
Summary: Brain tumors are a lethal type of cancer, and the blood-brain barrier presents a challenge for treatment. Mesenchymal stem cells (MSCs) and their derived exosomes show potential in treating brain tumors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Bin Zhang, Ruenn Chai Lai, Wei Kian Sim, Andre Boon Hwa Choo, Ellen Birgit Lane, Sai Kiang Lim
Summary: The topical application of MSC exosomes significantly reduced levels of IL-17 and C5b-9 in a mouse model of psoriasis, potentially by inhibiting complement activation and the release of NETs from neutrophils in the stratum corneum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hae-Ran Park, Yeo-Jin Choi, Jee-Young Kim, In-Gyu Kim, Uhee Jung
Summary: DLX2 is involved in cancer stemness, radioresistance, migration, invasion, and tumorigenic capability in surviving NSCLC cancer cells following fractionated irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang
Summary: As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes can be used as a potential tool for non-invasive liquid biopsy due to their presence in various body fluids. This study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). It also discusses the occurrence of EGFR+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kento Homma, Nikolay Bazhanov, Kazuki Hashimoto, Masaru Shimizu, Thomas Heathman, Qi Hao, Ranjana Nawgiri, Vidarshi Muthukumarana, Jae Woo Lee, Donald S. S. Prough, Perenlei Enkhbaatar
Summary: The pathogenesis of sepsis is an imbalance between pro-inflammatory and anti-inflammatory responses. MSC-derived extracellular vesicles (EVs) have shown beneficial effects for the treatment of acute lung injury (ALI) and sepsis. However, the present study demonstrated that EVs isolated from bone marrow-derived MSCs failed to attenuate the severity of multiorgan dysfunctions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Shengyu Jing, Hongjie Li, Hongbo Xu
Summary: In the latest research, mesenchymal stem cells derived exosomes (MSC-Exos) are identified as a potential alternative for treating refractory diabetic wounds. They have similar biological activity but less immunogenicity compared to MSCs. This review focuses on summarizing the effects of different MSC-Exos on diabetic wounds based on their origins and contents, discussing experimental conditions, target cells/pathways, and mechanisms. Additionally, the combination of MSC-Exos and biomaterials is explored to improve therapy efficacy and utilization. The clinical value and application prospects of exosome therapy, as well as the development trends of using exosomes as carriers for targeted delivery, are highlighted.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Cell Biology
Zeshu Zhu, Ping Zhu, Xiongwei Fan, Xiaoyang Mo, Xiushan Wu
Summary: This article summarizes that mesenchymal stem cells (MSCs) are a potent therapeutic strategy for repairing cardiac injury, but recent studies show that MSCs cannot survive in the heart for a long time. Consequently, the exosomes secreted by MSCs may play a dominant role in the repair of heart injury, promoting the restoration of cardiac cells, vascular proliferation, and immune regulation. The article also summarizes the current research on the acting mechanism, application prospects, and challenges of exosomes, including non-coding RNA, in repairing cardiac injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Genetics & Heredity
Nazoora Khan, Mohd Saad Umar, Mohamed Haq, Talha Rauf, Swaleha Zubair, Mohammad Owais
Summary: Tumorigenesis is a complex process involving the acquisition of various physiological traits by cancer cells. Non-coding RNAs (ncRNAs) play a crucial role in regulating multiple cell cycle processes and are considered important in the management of different types of cancer. ncRNAs can function as oncogenes or tumor suppressors and regulate unrestricted expansion, metastasis, and other biological processes in tumor cells. Dynamic attributes such as increased proliferation, migration, invasion, and epithelial-mesenchymal transition are significant determinants of tumor malignancy and therapeutic resistance. Furthermore, the interaction of ncRNAs with immune cells within the tumor microenvironment promotes tumor formation. Exosome-derived ncRNAs contribute to the maintenance of tumor hallmarks and further enhance the complexity of malignant neoplasia.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Xiaoyu Pu, Siyang Ma, Yan Gao, Tiankai Xu, Pengyu Chang, Lihua Dong
Summary: Radiation-induced damage is common in cancer patients undergoing radiotherapy, with mesenchymal stem cells and exosomes derived from them being ideal candidates for repair. Exosomes carry various bioactive substances that can affect immunomodulation, angiogenesis, cell survival, and proliferation, potentially providing new insights into the management of radiation damage.
Review
Biochemistry & Molecular Biology
Zhengjun Lin, Yanlin Wu, Yiting Xu, Guoqing Li, Zhihong Li, Tang Liu
Summary: This article systematically summarizes the roles and detailed molecular mechanisms of mesenchymal stem cell-derived exosomes (MSC-derived exosomes) in mediating cancer therapy resistance, providing novel insights into the clinical applications of MSC-derived exosomes in cancer management.
Review
Endocrinology & Metabolism
Chen Xia, Zhanqiu Dai, Yongming Jin, Pengfei Chen
Summary: Mesenchymal stem cell-derived exosomes have antioxidant properties that can explain their therapeutic effects through regulating redox environment and oxidative stress in a variety of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Medicinal
Wenyu Zhou, Song Hu, Yutong Wu, Huan Xu, Lina Zhu, Huimin Deng, Sheng Wang, Yuanli Chen, Huanping Zhou, Xin Lv, Quanfu Li, Hao Yang
Summary: This study provided a comprehensive overview and analysis of the application of mesenchymal stem cell-derived exosomes in acute lung injury and acute respiratory distress syndrome. It found that China and the USA have significant influence in this field, and COVID-19-induced lung injury has become a research hotspot.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Medicine, Research & Experimental
Cheng Wang, Honglin Zhou, Rui Wu, Yuqin Guo, Lihong Gong, Ke Fu, Cheng Ma, Cheng Peng, Yunxia Li
Summary: Liver disease is a major global health problem with high morbidity and mortality. Mesenchymal stem cell-derived exosomes (MSC-Exo) have shown similar physiological effects as mesenchymal stem cells (MSCs), providing a new strategy for liver disease treatment without immune rejection or tumor formation. Non-coding RNAs (ncRNAs) play a key role in the therapeutic effects of MSC-Exo, and this review comprehensively explores the molecular mechanisms and therapeutic effects on liver diseases, including liver injury, fibrosis, and hepatocellular carcinoma. These findings provide a basis for future exploration of MSC-Exo and ncRNAs in clinical liver disease treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Yi Li, Zhufu Shen, Xiao Jiang, Yuanyuan Wang, Zuozhang Yang, Yuchi Mao, Zhixian Wu, Gaofeng Li, Hong Chen
Summary: Exosomal miR-466f-3p derived from mMSCs exhibits anti-fibrotic properties and prevents radiation-induced EMT and lung fibrosis through inhibition of AKT/GSK3 beta pathway and c-MET.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)