An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides

Total Synthesis of Tetrahydropyran-Containing Natural Products Exploiting Intramolecular Oxa-Conjugate Cyclization

(2012) Haruhiko Fuwa   HETEROCYCLES

Bacterial Biosynthetic Gene Clusters Encoding the Anti-cancer Haterumalide Class of Molecules

(2012) Miguel A. Matilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Enzymatic Epoxidation Involved in Polyether Lasalocid Biosynthesis

(2012) Atsushi Minami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

(2012) Kinya Hotta et al.   NATURE

Insights into Lasalocid A Ring Formation by Chemical Chain Termination In Vivo

(2011) Manuela Tosin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211

(2011) Chunyan Jiang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster

(2011) Marie E. Yurkovich et al.   CHEMBIOCHEM

Enzymatic Epoxide-Opening Cascades Catalyzed by a Pair of Epoxide Hydrolases in the Ionophore Polyether Biosynthesis

(2011) Atsushi Minami et al.   ORGANIC LETTERS

Remarkable synergistic effect between MonBI and MonBII on epoxide opening reaction in ionophore polyether monensin biosynthesis

(2011) Kyohei Sato et al.   TETRAHEDRON LETTERS

Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS

(2010) Herbert Irschik  et al.   CHEMBIOCHEM

SmI2-induced reductive cyclizations for the synthesis of cyclic ethers and applications in natural product synthesis

(2010) Tadashi Nakata   CHEMICAL SOCIETY REVIEWS

Biosynthesis of ethers: Unusual or common natural events?

(2010) Pablo Domínguez de María et al.   NATURAL PRODUCT REPORTS

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Intriguing Substrate Tolerance of Epoxide Hydrolase Lsd19 Involved in Biosynthesis of the Ionophore Antibiotic Lasalocid A

(2010) Yusuke Matsuura et al.   ORGANIC LETTERS

Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase

(2010) Jianting Zheng et al.   STRUCTURE

Identification of a Gene Cluster of Polyether Antibiotic Lasalocid fromStreptomyces lasaliensis

(2009) Akira MIGITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure

(2008) Luke Smith et al.   CHEMBIOCHEM

A Type I/Type III Polyketide Synthase Hybrid Biosynthetic Pathway for the Structurally UniqueansaCompound Kendomycin

(2008) Silke C. Wenzel et al.   CHEMBIOCHEM

Epoxide Hydrolase Lsd19 for Polyether Formation in the Biosynthesis of Lasalocid A: Direct Experimental Evidence on Polyene-Polyepoxide Hypothesis in Polyether Biosynthesis

(2008) Yoshihiro Shichijo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Convergent strategies for the total synthesis of polycyclic ether marine metabolites

(2008) Makoto Sasaki et al.   NATURAL PRODUCT REPORTS