PhI(OAc)2-Mediated Radical Trifluoromethylation of Vinyl Azides with Me3SiCF3

The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and functional materials, owing to its unique properties such as electron-withdrawing character, metabolic stability, and lipophilicity. Described herein is the PhI(OAc)(2)-mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 to efficiently generate -trifluoromethyl azines. The resulting -trifluoromethyl azines were successfully transformed to valuable fluorine-containing molecules such as -trifluoromethyl ketones, -trifluoromethyl amines, 5-fluoropyrazoles, and trifluoroethyl isoquinolines.