期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 47, 期 3, 页码 840-848出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2015.3084
关键词
breast cancer; epithelial-mesenchymal transition; drug resistance; cancer stem cells; microRNA
类别
资金
- National Natural Science Foundation of China [81102007, 81472475]
- International S&T Cooperation Program of China (ISTCP) [2012DFA10650]
Breast cancer is the leading cause of cancer death in women worldwide. Insensitivity of tumor cells to drug therapies is an essential reason arousing such high mortality. Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. It is well known that EMT plays an important role in breast cancer progression. Recently, mounting evidence has demonstrated involvement of EMT in antagonizing chemotherapy in breast cancer. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target EMT to increase the efficacy of anticancer therapies.
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