Article
Biotechnology & Applied Microbiology
Yang Yang, Cecilia Laterza, Hannah T. Stuart, Federica Michielin, Onelia Gagliano, Anna Urciuolo, Nicola Elvassore
Summary: This study presents an in vitro model of human ectodermal patterning, which utilizes micropatterning technology and signal modulation to control the appearance and distribution of different ectodermal cell populations. It also investigates the cell sorting behavior of hPSC-derived meso-endoderm cells in a human context.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ievgeniia Topolniak, Anna Maria Elert, Xenia Knigge, Goksu Cinar Ciftci, Joerg Radnik, Heinz Sturm
Summary: This study demonstrates a PDA deposition method based on multiphoton lithography, which enables full control over spatial and temporal aspects, and allows for flexible pattern design. 2D microstructures with complex designs are achieved with high pattern precision, and the morphology and thickness of the fabricated microstructure can be adjusted within one deposition step, providing tunability of material properties. This work introduces a new method for high-precision and complete control of PDA deposition, enabling its incorporation in applications that require fine and precise local surface functionalization.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Pinak Samal, Jay Rabindra Kumar Samal, Eva Gubbins, Pascal Vroemen, Clemens van Blitterswijk, Roman Truckenmuller, Stefan Giselbrecht
Summary: This article presents a simple and accessible method for fabricating microstructures in polystyrene to guide cell behavior.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Lester Uy Vinzons, Shu-Ping Lin
Summary: Successful fabrication of photosensitive substrates with hierarchical structures using a simple and cost-effective method allows for the control of neuronal cell neurite outgrowth and alignment.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Farshad Oveissi, David F. Fletcher, Fariba Dehghani, Sina Naficy
Summary: This article reviews recent developments in hydrogel-based actuators and soft artificial muscles, discusses the fundamental principles behind the actuation of hydrogels, highlights the design details and properties of different tough hydrogel systems, and provides a brief conclusion on the remaining challenges in this field.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Man Zhang, Qian Sun, Yiling Liu, Zhiqin Chu, Leixiao Yu, Yong Hou, Heemin Kang, Qiang Wei, Weifeng Zhao, Joachim P. Spatz, Changsheng Zhao, Elisabetta A. Cavalcanti-Adam
Summary: Tunable mechanical properties of hydrogels play a key role in regulating stem cell differentiation. By modulating cellular spatial sensing of integrin-adhesive ligands on low stiffness hydrogels, the mechanosensing and osteogenic differentiation of MSCs can be promoted to levels comparable with those observed on stiffer hydrogels. This approach opens up new possibilities for designing biomaterials and tissue scaffolds for regenerative therapeutics.
Article
Engineering, Biomedical
Jingnan Zhang, Renping Zhao, Bin Li, Aleeza Farrukh, Markus Hoth, Bin Qu, Aranzazu del Campo
Summary: This study presents a method to fabricate micropatterned soft hydrogels for studying T cell activation under different stiffness and receptor presentation. The results show that the stiffness of the hydrogel affects the signaling pathways activated, while having no significant impact on actin rearrangement and ZAP70 phosphorylation.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Sara Ghavamian, Iain D. Hay, Ruhollah Habibi, Trevor Lithgow, Victor J. Cadarso
Summary: The use of 3D engineered surfaces has shown great potential in inhibiting bacterial colonization on medical devices, reducing the initial attachment and subsequent colonization of bacteria without the need for chemical treatments that may enhance antimicrobial resistance.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Enrico Tosoratti, Angela Bonato, Benjamin Kessel, Patrick Weber, Marcy Zenobi-Wong
Summary: A novel approach for the 3D culture of soft hydrogels is presented, using shape-defining, semi-permeable hydrogel shells to provide mechanical stability. This technique allows for the culture of previously inaccessible materials for tissue engineering and has the potential to change material property requirements in the field.
Article
Chemistry, Analytical
Shih-Jui Huang, Chia-Ming Chang, Yen-Ta Lu, Cheng-Hsien Liu
Summary: This study developed an integrated microfluidic biochip to separate target tumor cells and clusters from whole blood using a two-stage sorting mechanism. The chip achieved high recovery rates and purity in separating tumor cell clusters, making it suitable for cancer research and clinical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Multidisciplinary Sciences
Mingkun Wang, Shuofei Sun, Gening Dong, Feifei Long, Jonathan T. Butcher
Summary: We have successfully replicated the properties of load-bearing soft tissues using a thermomechanical approach. Our gelatin methacryloyl fiber hydrogel exhibits soft tissue-like mechanical properties, biochemical and architectural similarity to native extracellular matrix, and supports cell remodeling. This combination of mechanical properties and bioactivity is highly desirable for tissue engineering and regenerative medicine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Blaise Louis, Mukul Tewary, Andrew W. Bremer, Christina Philippeos, Victor A. Negri, Sebastiaan Zijl, Zev J. Gartner, David V. Schaffer, Fiona M. Watt
Summary: The balance between stem cell renewal and differentiation is influenced by intracellular controls and the microenvironment. This study investigated the effects of cell-ECM adhesion and cell-cell contact on the differentiation of keratinocytes. The findings suggest that cell-cell contact reduces differentiation in response to decreased substrate adhesion.
ACTA BIOMATERIALIA
(2022)
Review
Gastroenterology & Hepatology
Yang Yuan, Kristen Cotton, Dinithi Samarasekera, Salman R. Khetani
Summary: Liver diseases have a significant impact on global mortality and morbidity, but the use of animal models is limited by species-specific differences. Human liver cells derived from induced pluripotent stem cells offer an abundant resource, but current protocols yield immature phenotypes. Advanced techniques, such as protein micropatterning and 3-dimensional bioprinting, can enhance the maturation of these cells. Continued advancements in stem cell-derived liver models can provide human-relevant data earlier in drug development, aid in understanding liver disease mechanisms, and serve as cell-based therapies for end-stage liver failure patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Robotics
Edoardo Milana, Benjamin Gorissen, Eline De Borre, Frederik Ceyssens, Dominiek Reynaerts, Michael De Volder
Summary: This research proposes a fabrication technique using soft lithography to make out-of-plane bending microactuators. It enables the production of miniaturized and high-performance soft microsystems for applications in microfluidics and micromanipulation.
Article
Polymer Science
Kyuha Park, Heewon Choi, Kyumin Kang, Mikyung Shin, Donghee Son
Summary: In this study, a soft stretchable conductive hydrogel composite with good electrical and mechanical properties was reported. This material can stably sense physiological signals and provide feedback regulation in unstable biotic-abiotic interfaces.
Article
Chemistry, Analytical
Seongsoo Kim, Sang-Myung Lee, Sung Sik Lee, Dong-Sik Shin
Article
Biochemical Research Methods
So Min Kang, Hana Cho, Dasom Jeon, Seong Hyuk Park, Dong-Sik Shin, Chan Yeong Heo
Review
Chemistry, Multidisciplinary
Joonwon Bae, Jongnam Park, Seongsoo Kim, Hana Cho, Hye Jun Kim, Soyeon Park, Dong-Sik Shin
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2020)
Article
Chemistry, Analytical
Jin Hui Joo, Miae Won, Sun Young Park, Kyungeun Park, Dong-Sik Shin, Jong Seung Kim, Min Hee Lee
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Physical
Seongsoo Kim, Seohyeon Jee, Kyung Min Choi, Dong-Sik Shin
Summary: This study successfully achieved efficient Suzuki-Miyaura cross coupling reactions in aqueous media by designing discrete cages of metal-organic polyhedra anchoring single Pd atoms. The structure showed high stability and recyclability, making it a promising candidate for single-atom catalysis applications in water.
Article
Biochemical Research Methods
Joonwon Bae, Dong-Sik Shin, Ji-Hwan Ha, Yunjung Hwang, Chang-Soo Lee, Hye Jun Kim, Ayeon Jang, Sung-Hoon Park
Article
Biochemistry & Molecular Biology
Hayan Jeong, Jee Youn Shin, Kwanghyun Lee, Su-Jin Lee, Hyo-Jin Chong, Hyeri Jeong, Young-Eun Jeon, Dong-Sik Shin, Sunhyae Jang, Kyu Han Kim, Seok-In Kim, Yoon-Sik Lee, Bong-Gun Ju
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Analytical
Seongsoo Kim, Sang-Myung Lee, Je Pil Yoon, Namhun Lee, Jinhyo Chung, Woo-Jae Chung, Dong-Sik Shin
Article
Biochemical Research Methods
Joonwon Bae, Seon Joo Park, Dong-Sik Shin, Jiyeon Lee, Soyeon Park, Hye Jun Kim, Oh Seok Kwon
Summary: Dual functional conductive hydrogels containing polypyrrole nanotubes functionalized with beta-cyclodextrin and titania were produced and applied for detection and removal of toxic substances. The hydrogel exhibited good electrical properties and sensing capabilities, showing potential applications in various fields.
Article
Chemistry, Analytical
Hye-Lim Kang, Dong-ki Hong, Sumi Yoon, Sunga Song, Young Joo Kim, Won-Hyo Kim, Hana Cho, Hye-Won Kim, Woo-Kyeong Seong, Dong-Sik Shin, Kook-Nyung Lee
Summary: Detection of volatile organic compounds (VOCs) in exhaled breath is important for health assessment and disease diagnosis, but current small-sized VOC detectors lack sensitivity to detect low levels of VOCs. A proposed gas concentrator can effectively concentrate VOCs from exhaled breath to be detected by commercial VOC detectors, showing potential for disease diagnosis when combined with a gas analyzer or detector.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Hyeri Jeong, Young-Eun Jeon, Jin-Kyoung Yang, Jaehi Kim, Woo-Jae Chung, Yoon-Sik Lee, Dong-Sik Shin
Summary: Antioxidants, such as caffeic acid and its derivatives, play a crucial role in combating degenerative diseases and skin aging. The synthesized caffeoyl-prolyl-histidyl-Asn-NH2 derivative showed enhanced antioxidant activity and stability, making it a promising candidate for dermal therapeutic agents and cosmetic ingredients. Optimization of the solid-phase synthetic strategy allowed for large-scale production of these potentially beneficial compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Hyun-Seok Kim, Seongsoo Kim, Byung-Ho Shin, Chan-Yeong Heo, Omar Faruq, Le Thi Van Anh, Nilsu Donmez, Pham Ngoc Chien, Dong-Sik Shin, Sun-Young Nam, Rong-Min Baek
Summary: The coating of a biofunctionalized implant with interleukin-4 has been found to effectively reduce inflammation and fibrous capsular contracture, demonstrating promising results in tissue regeneration and immune reaction inhibition.
Article
Chemistry, Multidisciplinary
Hana Cho, Suhyun Shim, Won Woo Cho, Sungbo Cho, Hanseung Baek, Sang-Myung Lee, Dong-Sik Shin
Summary: This study developed a system for quantifying the nucleocapsid (N) protein in SARS-CoV-2, using an electro-immunosorbent assay and a multichannel impedance analyzer. The system showed highly specific, label-free detection with low cross-reactivity, and allowed for real-time detection of multiple samples.
Article
Chemistry, Analytical
Hana Cho, Sun Young Park, Dayoung Youn, Kyung Eun Park, Jin Hui Joo, Min Hee Lee, Dong-Sik Shin
Summary: The technology of single-cell microarrays enables the capture and detection of individual cell activity, and allows for the study of cell function and gene expression by controlling cell arrangement and using mitochondria-targetable probes in real-time.
Article
Materials Science, Multidisciplinary
Soon-Jae Lee, Kwang-Deok Choi, Su-Jin Lee, Dong-Sik Shin, Jae-Pil Jung
Summary: In order to improve the reliability and safety of electrical components in automobiles, researchers have used copper and aluminum as electrodes and employed lasers for rapid welding. However, in the welding of dissimilar metals such as aluminum and copper, the presence of intermetallic compounds (IMCs) reduces the strength of the weld. By using a high-quality laser with a high beam quality, researchers were able to increase the absorption rate and study the impact of welding speed on fracture behavior.
