期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 4, 页码 1152-1155出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201306271
关键词
absolute configuration; chiral mixtures; chirality; enantiomer identification; microwave spectroscopy
资金
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft
- United States Department of Energy
- Division Of Physics
- Direct For Mathematical & Physical Scien [1125846] Funding Source: National Science Foundation
Chirality-sensitive broadband microwave spectroscopy was performed on mixtures of carvone enantiomers and conformers to distinguish enantiomers, measure enantiomeric excesses, and determine the absolute configurations of the enantiomers. This method uses microwave three-wave mixing and is inherently well-suited to the analysis of mixturesa unique advantage over other techniques. In contrast to conventional microwave spectroscopy, the phase of the received signal is also exploited. This phase depends upon the signs of the molecules' dipole-moment components and is used to identify the excess enantiomer. The measured signal amplitude determines the size of the excess. The broadband capabilities of the spectrometer were used to simultaneously excite and measure two conformers of carvone, demonstrating the analysis of a sample with multiple chiral species. Employing quantum chemical calculations and the measured phases, the absolute configurations of the enantiomers are determined.
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